EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 19, 2011, Pages 7808-7813

  Portal, Daniel ^a   Zhao, Bo ^a   Calderwood, Michael A ^a   Sommermann, Thomas ^a   Johannsen, Eric ^a   Kieff, Elliott ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Lymphoma; Notch

Indexed keywords

ARGININE; CD23 ANTIGEN; EPSTEIN BARR VIRUS ANTIGEN; EPSTEIN BARR VIRUS ANTIGEN 2; GLUTAMIC ACID; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1; TUMOR SUPPRESSOR PROTEIN; VIRUS DNA;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; DNA BINDING; EPSTEIN BARR VIRUS; GENE DELETION; LYMPHOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE; CELL TRANSFORMATION, VIRAL; DNA; ENHANCER ELEMENTS, GENETIC; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 4, HUMAN; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; NUCLEAR RECEPTOR CO-REPRESSOR 1; NUCLEAR RECEPTOR CO-REPRESSOR 2; PROMOTER REGIONS, GENETIC; RECEPTORS, COMPLEMENT 3D; RECEPTORS, IGE; VIRAL PROTEINS;

HUMAN HERPESVIRUS 4;

EID: 79956348321     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1104991108     Document Type: Article

References (52)

1. Rickinson A, Kieff E (2007) Epstein-Barr virus. Fields Virology (Lippincott Williams & Wilkins, Philadelphia), 7th Ed, Vol 2, pp 2655-2700.
2. Alfieri C, Allison AC, Kieff E (1994) Effect of mycophenolic acid on Epstein-Barr virus infection of human B lymphocytes. Antimicrob Agents Chemother 38:126-129. (Pubitemid 24018168)
3. Nikitin PA, et al. (2010) An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. Cell Host Microbe 8:510-522.
4. Cohen JI, Wang F, Mannick J, Kieff E (1989) Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation. Proc Natl Acad Sci USA 86:9558-9562. (Pubitemid 20010466)
5. Hammerschmidt W, Sugden B (1989) Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes. Nature 340:393-397.
6. Grossman SR, Johannsen E, Tong X, Yalamanchili R, Kieff E (1994) The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein. Proc Natl Acad Sci USA 91:7568-7572.
7. Henkel T, Ling PD, Hayward SD, Peterson MG (1994) Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa. Science 265:92-95.
8. Yalamanchili R, et al. (1994) Genetic and biochemical evidence that EBNA 2 interaction with a 63-kDa cellular GTG-binding protein is essential for B lymphocyte growth transformation by EBV. Virology 204:634-641. (Pubitemid 24330868)
9. Zhao B, et al. (2006) RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines. Proc Natl Acad Sci USA 103:1900-1905. (Pubitemid 43228790)
10. Maier S, et al. (2006) Cellular target genes of Epstein-Barr virus nuclear antigen 2. J Virol 80:9761-9771. (Pubitemid 44435650)
11. Bark-Jones SJ, Webb HM, West MJ (2006) EBV EBNA 2 stimulates CDK9-dependent transcription and RNA polymerase II phosphorylation on serine 5. Oncogene 25:1775-1785.
12. Tong X, Wang F, Thut CJ, Kieff E (1995) The Epstein-Barr virus nuclear protein 2 acidic domain can interact with TFIIB, TAF40, and RPA70 but not with TATA-binding protein. J Virol 69:585-588. (Pubitemid 24378845)
13. Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E (1995) The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. Mol Cell Biol 15:4735-4744.
14. Tong X, Drapkin R, Reinberg D, Kieff E (1995) The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2. Proc Natl Acad Sci USA 92:3259-3263.
15. Wang L, Grossman SR, Kieff E (2000) Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter. Proc Natl Acad Sci USA 97:430-435.
16. Cohen JI, Kieff E (1991) An Epstein-Barr virus nuclear protein 2 domain essential for transformation is a direct transcriptional activator. J Virol 65:5880-5885.
17. Downes M, Ordentlich P, Kao HY, Alvarez JG, Evans RM (2000) Identification of a nuclear domain with deacetylase activity. Proc Natl Acad Sci USA 97:10330-10335.
18. Kao HY, Downes M, Ordentlich P, Evans RM (2000) Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev 14:55-66. (Pubitemid 30051579)
19. Oswald F, et al. (2002) SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. EMBO J 21:5417-5426. (Pubitemid 35231021)
20. Yu J, Li Y, Ishizuka T, Guenther MG, Lazar MA (2003) A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation. EMBO J 22:3403-3410. (Pubitemid 36834870)
21. Zhou S, et al. (2000) SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol 20:2400-2410. (Pubitemid 30152048)
22. Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (2000) A role for SKIP in EBNA2 activation of CBF1-repressed promoters. J Virol 74:1939-1947. (Pubitemid 30434053)
23. Goodson ML, Jonas BA, Privalsky ML (2005) Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. J Biol Chem 280:7493-7503. (Pubitemid 40349641)
24. Voss TC, Demarco IA, Booker CF, Day RN (2005) Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus. J Cell Sci 118:3277-3288. (Pubitemid 41246085)
25. Voss TC, Demarco IA, Booker CF, Day RN (2005) Corepressor subnuclear organization is regulated by estrogen receptor via a mechanism that requires the DNA-binding domain. Mol Cell Endocrinol 231:33-47. (Pubitemid 40248815)
26. Zhou S, Hayward SD (2001) Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. Mol Cell Biol 21:6222-6232. (Pubitemid 34263522)
27. Mannick JB, Cohen JI, Birkenbach M, Marchini A, Kieff E (1991) The Epstein-Barr virus nuclear protein encoded by the leader of the EBNA RNAs is important in Blymphocyte transformation. J Virol 65:6826-6837.
28. Harada S, Kieff E (1997) Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation. J Virol 71:6611-6618. (Pubitemid 27355319)
29. McCann EM, Kelly GL, Rickinson AB, Bell AI (2001) Genetic analysis of the Epstein-Barr virus-coded leader protein EBNA-LP as a co-activator of EBNA2 function. J Gen Virol 82:3067-3079. (Pubitemid 33107523)
30. Portal D, Rosendorff A, Kieff E (2006) Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4. Proc Natl Acad Sci USA 103:19278-19283. (Pubitemid 46026024)
31. Peng CW, Zhao B, Kieff E (2004) Four EBNA2 domains are important for EBNALP coactivation. J Virol 78:11439-11442. (Pubitemid 39299690)
32. Peng R, Tan J, Ling PD (2000) Conserved regions in the Epstein-Barr virus leader protein define distinct domains required for nuclear localization and transcriptional cooperation with EBNA2. J Virol 74:9953-9963.
33. Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F (2000) A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element. J Biol Chem 275:21396-21401. (Pubitemid 30481840)
34. Han I, et al. (2001) EBNA-LP associates with cellular proteins including DNA-PK and HA95. J Virol 75:2475-2481. (Pubitemid 32147588)
35. Han I, et al. (2002) Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins. Mol Cell Biol 22:2136-2146. (Pubitemid 34224621)
36. Martins SB, et al. (2000) HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics. J Cell Sci 113:3703-3713.
37. Orstavik S, et al. (2000) Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95. Biol Cell 92:27-37. (Pubitemid 30157791)
38. Li Y, et al. (2006) A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev 20:2566-2579. (Pubitemid 44396841)
39. Ling PD, et al. (2005) Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100. EMBO J 24:3565-3575. (Pubitemid 41509364)
40. Peng CW, et al. (2007) Hsp72 up-regulates Epstein-Barr virus EBNALP coactivation with EBNA2. Blood 109:5447-5454.
41. Goodson M, Jonas BA, Privalsky MA (2005) Corepressors: Custom tailoring and alterations while you wait. Nucl Recept Signal 3:e003.
42. Jones PL, Sachs LM, Rouse N, Wade PA, Shi YB (2001) Multiple N-CoR complexes contain distinct histone deacetylases. J Biol Chem 276:8807-8811.
43. Jones PL, Shi YB (2003) N-CoR-HDAC corepressor complexes: Roles in transcriptional regulation by nuclear hormone receptors. Curr Top Microbiol Immunol 274:237-268. (Pubitemid 36118994)
44. Perissi V, Jepsen K, Glass CK, Rosenfeld MG (2010) Deconstructing repression: Evolving models of co-repressor action. Nat Rev Genet 11:109-123.
45. Perissi V, et al. (2008) TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Mol Cell 29:755-766. (Pubitemid 351400927)
46. Young LS, Rickinson AB (2004) Epstein-Barr virus: 40 years on. Nat Rev Cancer 4: 757-768. (Pubitemid 39331148)
47. Krejcí A, Bray S (2007) Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev 21:1322-1327. (Pubitemid 46871036)
48. Carroll KD, et al. (2006) Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway. J Virol 80:9697-9709. (Pubitemid 44435644)
49. Harada S, Yalamanchili R, Kieff E (1998) Residues 231 to 280 of the Epstein-Barr virus nuclear protein 2 are not essential for primary B-lymphocyte growth transformation. J Virol 72:9948-9954. (Pubitemid 28520862)
50. Gross H, et al. (2010) Asymmetric Arginine dimethylation of Epstein-Barr virus nuclear antigen 2 promotes DNA targeting. Virology 397:299-310.
51. Peng R, Moses SC, Tan J, Kremmer E, Ling PD (2005) The Epstein-Barr virus EBNA-LP protein preferentially coactivates EBNA2-mediated stimulation of latent membrane proteins expressed from the viral divergent promoter. J Virol 79:4492-4505. (Pubitemid 40388386)
52. Wang F, et al. (1990) Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23. J Virol 64:2309-2318. (Pubitemid 20148479)