Molecular drug susceptibility testing and genotyping of Mycobacterium leprae strains from South America

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 6, 2011, Pages 2971-2973

  Singh, Pushpendra ^a   Busso, Philippe ^a   Paniz Mondolfi, Alberto ^b   Aranzazu, Nacarid ^b   Monot, Marc ^c   Honore, Nadine ^c   De Faria Fernandes Belone, Andrea ^d   Virmond, Marcos ^d   Villarreal Olaya, Maria Esther ^e   Rivas, Carlos ^f   Cole, Stewart T ^a  

^a EPFL   (Switzerland)

^b INSTITUTO DE BIOMEDICINA   (Venezuela)

^c INSTITUT PASTEUR   (France)

^d INSTITUTO LAURO DE SOUZA LIMA   (Brazil)

^e National Leprosy Program   (Bolivia)

^f Honorary Anti Tuberculosis Commission   (Uruguay)

Author keywords

[No Author keywords available]

Indexed keywords

DAPSONE; OFLOXACIN; RIFAMPICIN;

ADOLESCENT; ADULT; AGED; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL MUTATION; BACTERIAL STRAIN; BOLIVIA; BRAZIL; DISEASE CONTROL; DNA EXTRACTION; DRUG SCREENING; FEMALE; GENETIC RESISTANCE; GENOTYPE; HUMAN; HUMAN TISSUE; LEPROSY; MALE; MOLECULAR DRUG SUSCEPTIBILITY TESTING; MYCOBACTERIUM LEPRAE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN BIOPSY; URUGUAY; VENEZUELA;

ADOLESCENT; ADULT; AGED; DRUG RESISTANCE, BACTERIAL; FEMALE; GENOTYPE; HUMANS; LEPROSY; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MYCOBACTERIUM LEPRAE; POLYMORPHISM, SINGLE NUCLEOTIDE; SOUTH AMERICA;

EID: 79956327056     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00201-11     Document Type: Article

References (28)

1. Cambau, E., et al. 2002. Molecular detection of rifampin and ofloxacin resistance for patients who experience relapse of multibacillary leprosy. Clin. Infect. Dis. 34:39-45.
2. Cambau, E., L. Carthagena, A. Chauffour, B. Ji, and V. Jarlier. 2006. Dihydropteroate synthase mutations in the folP1 gene predict dapsone resistance in relapsed cases of leprosy. Clin. Infect. Dis. 42:238-241.
3. Cambau, E., E. Perani, I. Guillemin, P. Jamet, and B. Ji. 1997. Multidrug-resistance to dapsone, rifampicin, and ofloxacin in Mycobacterium leprae. Lancet 349:103-104. (Pubitemid 27023435)
4. dela Cruz, E., et al. 1996. Primary dapsone resistance in Cebu, The Philippines; cause for concern. Int. J. Lepr. Other Mycobact. Dis. 64:253-256.
5. Ebenezer, G. J., G. Norman, G. A. Joseph, S. Daniel, and C. K. Job. 2002. Drug resistant Mycobacterium leprae - results of mouse footpad studies from a laboratory in south India. Indian J. Lepr. 74:301-312.
6. Grosset, J. H., et al. 1989. Study of 39 documented relapses of multibacillary leprosy after treatment with rifampin. Int. J. Lepr. Other Mycobact. Dis. 57:607-614.
7. Gupta, U. D., K. Katoch, and V. M. Katoch. 2009. Study of rifampicin resistance and comparison of dapsone resistance of Mycobacterium leprae in pre- and post-MDT era. Indian J. Lepr. 81:131-134.
8. Honore, N., and S. T. Cole. 1993. Molecular basis of rifampin resistance in Mycobacterium leprae. Antimicrob. Agents Chemother. 37:414-418.
9. Kim, S. K., S. B. Lee, T. J. Kang, and G. T. Chae. 2003. Detection of gene mutations related with drug resistance in Mycobacterium leprae from leprosy patients using touch-down (TD) PCR. FEMS Immunol. Med. Microbiol. 36:27-32.
10. Lopez-Roa, R. I., M. Fafutis-Morris, and M. Matsuoka. 2006. A drug-resistant leprosy case detected by DNA sequence analysis from a relapsed Mexican leprosy patient. Rev. Latinoam. Microbiol. 48:256-259.
11. Maeda, S. 2004. Multi-drug resistant Mycobacterium leprae from patients with leprosy. Nihon Hansenbyo Gakkai Zasshi 73:227-233. (In Japanese.)
12. Maeda, S., et al. 2001. Multidrug resistant Mycobacterium leprae from patients with leprosy. Antimicrob. Agents Chemother. 45:3635-3639.
13. Matsuoka, M. 2010. Drug resistance in leprosy. Jpn. J. Infect. Dis. 63:1-7.
14. Matsuoka, M., et al. 2007. The frequency of drug resistance mutations in Mycobacterium leprae isolates in untreated and relapsed leprosy patients from Myanmar, Indonesia and the Philippines. Lepr. Rev. 78:343-352.
15. Matsuoka, M., Y. Kashiwabara, Z. Liangfen, M. Goto, and S. Kitajima. 2003. A second case of multidrug-resistant Mycobacterium leprae isolated from a Japanese patient with relapsed lepromatous leprosy. Int. J. Lepr. Other Mycobact. Dis. 71:240-243.
16. Matsuoka, M., Y. Kashiwabara, and M. Namisato. 2000. A Mycobacterium leprae isolate resistant to dapsone, rifampin, ofloxacin and sparfloxacin. Int. J. Lepr. Other Mycobact. Dis. 68:452-455.
17. Monot, M., et al. 2005. On the origin of leprosy. Science 308:1040-1042. (Pubitemid 40664418)
18. Monot, M., et al. 2009. Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nat. Genet. 41:1282-1289.
19. Namisato, M., M. Matsuoka, Y. Kashiwabara, and M. Higashi. 2002. Drug resistance in the treatment of leprosy: study in the relapsed cases found in Japanese leprosaria. Jpn. J. Natl. Med. Serv. 56:331-337.
20. Pearson, T. M. H., R. T. W. Rees, and M. F. R. Waters. 1975. Sulphone resistance in leprosy: a review of one hundred proven clinical cases. Lancet 306:69-72.
21. Pettit, J. H. S., and R. J. W. Rees. 1964. Sulphone resistance in leprosy: an experimental and clinical study. Lancet 284:673-674.
22. Shetty, V. P., M. W. Uplekar, and N. H. Antia. 1996. Primary resistance to single and multiple drugs in leprosy - a mouse footpad study. Lepr. Rev. 67:280-286.
23. Williams, D. L., and T. P. Gillis. 2004. Molecular detection of drug resistance in Mycobacterium leprae. Lepr. Rev. 75:118-130.
24. Woods, S. A., and S. T. Cole. 1989. A rapid method for the detection of potentially viable Mycobacterium leprae in human biopsies: a novel application of PCR. FEMS Microbiol. Lett. 53:305-309.
25. World Health Organization. 2010. Global leprosy situation, 2010. Wkly. Epidemiol. Rec. 85:337-348.
26. World Health Organization. 2006. Global strategy for further reducing the leprosy burden and sustaining leprosy control activities: plan period 2006-2010. WHO, Geneva, Switzerland. http://203.90.70.117/catalogue/2006-2010/ leprosy.htm.
27. World Health Organization. 2010. Surveillance of drug resistance in leprosy: 2009. Wkly. Epidemiol. Rec. 85:281-284.
28. You, E. Y., T. J. Kang, S. K. Kim, S. B. Lee, and G. T. Chae. 2005. Mutations in genes related to drug resistance in Mycobacterium leprae isolates from leprosy patients in Korea. J. Infect. 50:6-11.