Topical imiquimod treatment of aciclovir-resistant herpes simplex disease: Case series and literature review

Sexually Transmitted Infections

Volumn 87, Issue 4, 2011, Pages 292-295

  Perkins, Nicky ^a   Nisbet, Mitzi ^a   Thomas, Mark ^a  

^a AUCKLAND DISTRICT HEALTH BOARD   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; AMOXICILLIN PLUS CLAVULANIC ACID; CEFTRIAXONE; CHLORAMBUCIL; CIDOFOVIR; COTRIMOXAZOLE; EFAVIRENZ; EMTRICITABINE; FLUCLOXACILLIN; FLUDARABINE; FOSCARNET; IMIQUIMOD; INDINAVIR; LAMIVUDINE; METRONIDAZOLE; MITOXANTRONE; RITUXIMAB; TENOFOVIR; VALACICLOVIR; ZIDOVUDINE;

ADULT; AGED; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; B CELL LYMPHOMA; BACTERIAL SUPERINFECTION; CANCER COMBINATION CHEMOTHERAPY; CASE REPORT; CD4 LYMPHOCYTE COUNT; CONDYLOMA ACUMINATUM; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; FEMALE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HOSPITAL READMISSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCOMPROMISED PATIENT; IMMUNOSTIMULATION; LYMPHADENOPATHY; MAINTENANCE THERAPY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MULTIPLE CYCLE TREATMENT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TREATMENT REFUSAL; UNSPECIFIED SIDE EFFECT; VIRUS LOAD;

ACYCLOVIR; ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, TOPICAL; ADULT; AGED; AMINOQUINOLINES; ANTIVIRAL AGENTS; DRUG RESISTANCE, VIRAL; FATAL OUTCOME; FEMALE; HERPES GENITALIS; HUMANS; IMMUNOCOMPROMISED HOST; MALE; MIDDLE AGED;

EID: 79956277591     PISSN: 13684973     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/sti.2010.047431     Document Type: Article

References (16)

1. Malkin JE. Epidemiology of genital herpes simplex virus infection in developed countries. Herpes 2004;11(Suppl 1):2-23A.
2. Weiss H. Epidemiology of herpes simplex virus type 2 infection in developing countries. Herpes 2004;11(Suppl 1):24-35A.
3. Strick L, Wald A, Celum C. Management of herpes simplex virus type 2 infection in HIV type 1 infected persons. Clin Infect Dis 2006;43:347-56. (Pubitemid 44078908)
4. Bacon T, Levin M, Leary J, et al. Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy. Clin Microbiol Rev 2003;16:114-28. (Pubitemid 36114710)
5. British Association for Sexual Health and HIV (BASHH). Clinical effectiveness group guidelines. http://www.bashh.org/guidelines (accessed 17 Sep 2010).
6. Hengge U, Benninghoff B, Ruzicka T, et al. Topical immunomodulators - progress towards treating inflammation, infection and cancer. Lancet Infect Dis 2001;1:189-98. (Pubitemid 33586052)
7. Harrison CJ, Miller RL, Bernstein DI. Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs. Antimicrob Agents Chemother 1994;38:2059-64. (Pubitemid 24278801)
8. Bernstein DI, Harrison CJ, Tomai MA, et al. Daily or weekly therapy with resimiquimod (R-848) reduces genital recurrences in herpes simplex virus-infected guinea pigs during and after treatment. J Infect Dis 2001; 183:844-9. (Pubitemid 32207051)
9. Lautenschlager S, Schwarzkopf S, Keller B. Exophytic ulcerated tumors in HIV patients: diagnostic and therapeutic problems. Dermatology 2008;216:60-3. (Pubitemid 350158738)
10. Gilbert J, Drehs M, Weinberg J, et al. Topical imiquimod for acyclovir-unresponsive herpes simplex virus 2 infection. Arch Dermatol 2001;137:1015-17. (Pubitemid 32756458)
11. Martinez V, Molina JM, Scieux C, et al. Topical imiquimod for recurrent aciclovir-resistant HSV infection. Am J Med 2006;119:e9-11.
12. Yudin M, Kaul R. Progressive hypertrophic genital herpes in an HIV-infected woman despite immune recovery on antiretroviral therapy. Infect Dis Obstet Gynecol 2008;2008:592532.
13. Abbo L, Vincek V, Dickinson G, et al. Selective defect in plasmacytoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. Clin Infect Dis 2007;44:e25-7.
14. Danielson AG, Petersen CS, Iverson J. Chronic erosive herpes simplex virus infection of the penis in a human immunodeficiency virus-positive man, treated with imiquimod and famciclovir. Br J Dermatol 2002;147:1034-5.
15. Brummit CF. Imiquimod 5% cream for the treatment of recurrent acyclovir-resistant genital herpes. Clin Infect Dis 2006;42:575.
16. Bangsgaard N, Skov L. Chronic genital ulceration due to herpes simplex infection treated successfully with imiquimod. Acta Derm Venereol 2008;88:202-3. (Pubitemid 351507212)