Brain histamine H1 receptor occupancy of loratadine measured by positron emission topography: Comparison of H1 receptor occupancy and proportional impairment ratio

Human Psychopharmacology

Volumn 26, Issue 2, 2011, Pages 133-139

  Kubo, Nobuo ^a,e   Senda, Michio ^b   Ohsumi, Yasunori ^a   Sakamoto, Setsu ^b   Matsumoto, Keiichi ^b   Tashiro, Manabu ^c   Okamura, Nobuyuki ^d   Yanai, Kazuhiko ^c,d  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b INSTITUTE OF BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e OSAKA DENTAL UNIVERSITY   (Japan)

Author keywords

H1 antihistamine; histamine H1 receptor occupancy; loratadine; non sedating; positron emission tomography (PET); proportional impairment ratio

Indexed keywords

ASTEMIZOLE; AZELASTINE; BETOTASTINE; CETIRIZINE; DEXCHLORPHENIRAMINE; DEXCHLORPHENIRAMINE MALEATE; DIPHENHYDRAMINE; DOXEPIN C 11; EBASTINE; EPINASTINE; FEXOFENADINE; HISTAMINE H1 RECEPTOR; HYDROXYZINE; KETOTIFEN; LORATADINE; MEQUITAZINE; OLOPATADINE; OXATOMIDE; PLACEBO; RADIOPHARMACEUTICAL AGENT; TERFENADINE; UNCLASSIFIED DRUG;

ADULT; ALLERGIC RHINITIS; ARTICLE; BRAIN SCINTISCANNING; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG RECEPTOR BINDING; FRONTAL CORTEX; HUMAN; MALE; OCCIPITAL CORTEX; PARIETAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR OCCUPANCY; SEDATION; SINGLE DRUG DOSE; SOMNOLENCE; TEMPORAL CORTEX; THALAMUS;

ADULT; BRAIN; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; HISTAMINE H1 ANTAGONISTS; HUMANS; LORATADINE; MALE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RECEPTORS, HISTAMINE H1; YOUNG ADULT;

EID: 79956270668     PISSN: 08856222     EISSN: 10991077     Source Type: Journal    
DOI: 10.1002/hup.1184     Document Type: Article

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