A globally available internet-based patient survey of pemphigus vulgaris: Epidemiology and disease characteristics

Dermatologic Clinics

Volumn 29, Issue 3, 2011, Pages 393-404

  Gupta, Vibha K ^a   Kelbel, Theodore E ^a   Nguyen, Daniela ^b   Melonakos, Katherine C ^a   Murrell, Dédée F ^c   Xie, Yan ^a   Mullard, Andrew ^d   Reed, Philip L ^d   Seiffert Sinha, Kristina ^a,e   Sinha, Animesh A ^a,e  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d MICHIGAN STATE UNIVERSITY   (United States)

^e UNIVERSITY AT BUFFALO   (United States)

Author keywords

Autoimmune disease comorbidity and family history; Epidemiology; Online survey; Pemphigus vulgaris; Trigger factors

Indexed keywords

ADULT; AGED; COMORBIDITY; DEMOGRAPHY; DISEASE ASSOCIATION; EPIDEMIOLOGICAL DATA; FAMILY HISTORY; FEMALE; GENETIC ASSOCIATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INTERNET; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MUCOSAL DISEASE; ONSET AGE; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SEX DIFFERENCE; SKIN DEFECT; THYROID DISEASE;

ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; CANDIDIASIS; COMORBIDITY; EPSTEIN-BARR VIRUS INFECTIONS; FAMILY HEALTH; FEMALE; HEALTH SURVEYS; HEPATITIS C; HERPES SIMPLEX; HERPES ZOSTER; HUMANS; INTERNET; MALE; MIDDLE AGED; PEMPHIGUS; STAPHYLOCOCCAL INFECTIONS; STREPTOCOCCAL INFECTIONS; WORLD HEALTH;

EID: 79956260860     PISSN: 07338635     EISSN: 15580520     Source Type: Journal    
DOI: 10.1016/j.det.2011.03.016     Document Type: Review

References (74)

1. Salmanpour R., Shahkar H., Namazi M.R., et al. Epidemiology of pemphigus in south-western Iran: a 10-year retrospective study (1991-2000). Int J Dermatol 2006, 45(2):103-105.
2. Asilian A., Yoosefi A., Faghini G. Pemphigus vulgaris in Iran: epidemiology and clinical profile. Skinmed 2006, 5(2):69-71.
3. Langan S.M., Smeeth L., Hubbard R., et al. Bullous pemphigoid and pemphigus vulgaris-incidence and mortality in the UK: population based cohort study. BMJ 2008, 337:a180.
4. Bystryn J.C., Rudolph J.L. Pemphigus. Lancet 2005, 366(9479):61-73.
5. Nanda A., Dvorak R., Al-Saeed K., et al. Spectrum of autoimmune bullous diseases in Kuwait. Int J Dermatol 2004, 43(12):876-881.
6. Sinha A.A., Lopez M.T., McDevitt H.O. Autoimmune diseases: the failure of self tolerance. Science 1990, 248(4961):1380-1388.
7. Sinha A.A., Brautbar C., Szafer F., et al. A newly characterized HLA DQ beta allele associated with pemphigus vulgaris. Science 1988, 239(4843):1026-1029.
8. Lee E., Lendas K.A., Chow S., et al. Disease relevant HLA class II alleles isolated by genotypic, haplotypic, and sequence analysis in North American Caucasians with pemphigus vulgaris. Hum Immunol 2006, 67(1-2):125-139.
9. Brenner S., Wohl Y. A survey of sex differences in 249 pemphigus patients and possible explanations. Skinmed 2007, 6(4):163-165.
10. Chams-Davatchi C., Valikhani M., Daneshpazhooh M., et al. Pemphigus: analysis of 1209 cases. Int J Dermatol 2005, 44(6):470-476.
11. Michailidou E.Z., Belazi M.A., Markopoulos A.K., et al. Epidemiologic survey of pemphigus vulgaris with oral manifestations in northern Greece: retrospective study of 129 patients. Int J Dermatol 2007, 46(4):356-361.
12. Tallab T., Joharji H., Bahamdan K., et al. The incidence of pemphigus in the southern region of Saudi Arabia. Int J Dermatol 2001, 40(9):570-572.
13. Tsankov N., Vassileva S., Kamarashev J., et al. Epidemiology of pemphigus in Sofia, Bulgaria. A 16-year retrospective study (1980-1995). Int J Dermatol 2000, 39(2):104-108.
14. Uzun S., Durdu M., Akman A., et al. Pemphigus in the Mediterranean region of Turkey: a study of 148 cases. Int J Dermatol 2006, 45(5):523-528.
15. Fox S. Online Health Search 2006 Available at:, Accessed December 23, 2010. http://www.pewinternet.org/Reports/2006/Online-Health-Search-2006.aspx.
16. Cumming G.P., Currie H.D., Moncur R., et al. Web-based survey on the effect of menopause on women's libido in a computer-literate population. Menopause Int 2009, 15(1):8-12.
17. Oladimeji O., Farris K.B., Urmie J.G., et al. Risk factors for self-reported adverse drug events among Medicare enrollees. Ann Pharmacother 2008, 42(1):53-61.
18. Dawn A., Papoiu A.D., Chan Y.H., et al. Itch characteristics in atopic dermatitis: results of a web-based questionnaire. Br J Dermatol 2009, 160(3):642-644.
19. Kelly M.D. Traumatic neuralgia from pressure-point strikes in the martial arts: results from a retrospective online survey. J Am Osteopath Assoc 2008, 108(6):284-287.
20. Anthony J., Heeter C., Reed P.L., et al. Longitudinal study engine users manual. Version 1.0 Available at:, Accessed January 12, 2010. http://bric.msu.edu/?q=node/26.
21. Harman K.E., Gratian M.J., Bhogal B.S., et al. A study of desmoglein 1 autoantibodies in pemphigus vulgaris: racial differences in frequency and the association with a more severe phenotype. Br J Dermatol 2000, 143(2):343-348.
22. Lee E., Sinha A.A. T cell targeted immunotherapy for autoimmune disease. Autoimmunity 2005, 38(8):577-596.
23. Murrell D.F., Dick S., Ahmed A.R., et al. Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus. J Am Acad Dermatol 2008, 58(6):1043-1046.
24. Humbert P., Dupond J.L., Vuitton D., et al. Dermatological autoimmune diseases and the multiple autoimmune syndromes. Acta Derm Venereol Suppl (Stockh) 1989, 148:1-8.
25. Mohan M.P., Ramesh T.C. Multiple autoimmune syndrome. Indian J Dermatol Venereol Leprol 2003, 69(4):298-299.
26. Bordel-Gomez M.T., Sanchez-Estella J., Yuste-Chaves M., et al. Actas Dermosifiliogr 2006, 97(8):509-513. [in Spanish].
27. Brenner S., Wolf R. Possible nutritional factors in induced pemphigus. Dermatology 1994, 189(4):337-339.
28. Feliciani C., Ruocco E., Zampetti A., et al. Tannic acid induces in vitro acantholysis of keratinocytes via IL-1alpha and TNF-alpha. Int J Immunopathol Pharmacol 2007, 20(2):289-299.
29. Aboobaker J., Morar N., Ramdial P.K., et al. Pemphigus in South Africa. Int J Dermatol 2001, 40(2):115-119.
30. Golusin Z., Poljacki M., Jovanovic M., et al. Some epidemiological features of pemphigus chronicus in South Vojvodina: a 12-year retrospective study. Int J Dermatol 2005, 44(9):792-793.
31. Hahn-Ristic K., Rzany B., Amagai M., et al. Increased incidence of pemphigus vulgaris in southern Europeans living in Germany compared with native Germans. J Eur Acad Dermatol Venereol 2002, 16(1):68-71.
32. Heymann A.D., Chodick G., Kramer E., et al. Pemphigus variant associated with penicillin use: a case-cohort study of 363 patients from Israel. Arch Dermatol 2007, 143(6):704-707.
33. Hietanen J., Salo O.P. Pemphigus: an epidemiological study of patients treated in Finnish hospitals between 1969 and 1978. Acta Derm Venereol 1982, 62(6):491-496.
34. Micali G., Musumeci M.L., Nasca M.R. Epidemiologic analysis and clinical course of 84 consecutive cases of pemphigus in eastern Sicily. Int J Dermatol 1998, 37(3):197-200.
35. Seo P.G., Choi W.W., Chung J.H. Pemphigus in Korea: clinical manifestations and treatment protocol. J Dermatol 2003, 30(11):782-788.
36. Shamsadini S., Fekri A.R., Esfandiarpoor I., et al. Determination of survival and hazard functions for pemphigus patients in Kerman, a southern province of Iran. Int J Dermatol 2006, 45(6):668-671.
37. Valikhani M., Kavusi S., Chams-Davatchi C., et al. Pemphigus and associated environmental factors: a case-control study. Clin Exp Dermatol 2007, 32(3):256-260.
38. V'Lckova-Laskoska M.T., Laskoski D.S., Kamberova S., et al. Epidemiology of pemphigus in Macedonia: a 15-year retrospective study (1990-2004). Int J Dermatol 2007, 46(3):253-258.
39. Wohl Y., Brenner S. Pemphigus in Israel-an epidemiologic analysis of cases in search of risk factors. Isr Med Assoc J 2003, 5(6):410-412.
40. Simon D.G., Krutchkoff D., Kaslow R.A., et al. Pemphigus in Hartford County, Connecticut, from 1972 to 1977. Arch Dermatol 1980, 116(9):1035-1037.
41. McCarthy M. The " gender gap" in autoimmune disease. Lancet 2000, 356(9235):1088.
42. Abreu-Velez A.M., Hashimoto T., Bollag W.B., et al. A unique form of endemic pemphigus in northern Colombia. J Am Acad Dermatol 2003, 49(4):599-608.
43. Bastuji-Garin S., Turki H., Mokhtar I., et al. Possible relation of Tunisian pemphigus with traditional cosmetics: a multicenter case-control study. Am J Epidemiol 2002, 155(3):249-256.
44. Firooz A., Mazhar A., Ahmed A.R. Prevalence of autoimmune diseases in the family members of patients with pemphigus vulgaris. J Am Acad Dermatol 1994, 31(3 Pt 1):434-437.
45. Goon A.T., Tan S.H. Comparative study of pemphigus vulgaris and pemphigus foliaceus in Singapore. Australas J Dermatol 2001, 42(3):172-175.
46. O'Rourke D., Lakner E. Gender bias: analysis of factors causing male underrepresentation in surveys. Int J Publ Opin Res 1989, 1(2):164-176.
47. Amagai M., Tsunoda K., Zillikens D., et al. The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile. J Am Acad Dermatol 1999, 40(2 Pt 1):167-170.
48. Mahoney M.G., Wang Z., Rothenberger K., et al. Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest 1999, 103(4):461-468.
49. Kalish R.S. Pemphigus vulgaris: the other half of the story. J Clin Invest 2000, 106(12):1433-1435.
50. Yoshida K., Takae Y., Saito H., et al. Cutaneous type pemphigus vulgaris: a rare clinical phenotype of pemphigus. J Am Acad Dermatol 2005, 52(5):839-845.
51. Saha M., Harman K., Mortimer N.J., et al. Pemphigus vulgaris in White Europeans is linked with HLA class II allele HLA DRB1*1454 but not DRB1*1401. J Invest Dermatol 2010, 130:311-314.
52. Biro E., Szekanecz Z., Czirjak L., et al. Association of systemic and thyroid autoimmune diseases. Clin Rheumatol 2006, 25(2):240-245.
53. Yalcin B., Tamer E., Toy G.G., et al. Development of pemphigus vulgaris in a patient with vitiligo and Hashimoto's thyroiditis. J Endocrinol Invest 2005, 28(6):558-560.
54. Iino Y., Hara H., Suda T., et al. Co-existence of pemphigus vulgaris and Hashimoto's thyroiditis. Eur J Dermatol 2005, 15(1):40-42.
55. Pitoia F., Moncet D., Glorio R., et al. Prevalence of thyroid autoimmunity in patients with pemphigus vulgaris. Medicina (B Aires) 2005, 65(4):307-310.
56. Altekruse SF, Kosary CL, Krapcho M, et al, editors. SEER cancer statistics review, 1975-2007, National Cancer Institute. Bethesda, MD. Available at: , based on November 2009 SEER data submission, posted to the SEER web site, 2010. http://seer.cancer.gov/csr/1975_2007/.
57. Zhu X., Zhang B. Paraneoplastic pemphigus. J Dermatol 2007, 34(8):503-511.
58. Cremniter D., Baudin M., Roujeau J.C., et al. Stressful life events as potential triggers of pemphigus. Arch Dermatol 1998, 134(11):1486-1487.
59. Morell-Dubois S., Carpentier O., Cottencin O., et al. Stressful life events and pemphigus. Dermatology 2008, 216(2):104-108.
60. Aoki V., Millikan R.C., Rivitti E.A., et al. Environmental risk factors in endemic pemphigus foliaceus (fogo selvagem). J Investig Dermatol Symp Proc 2004, 9(1):34-40.
61. Brenner S., Tur E., Shapiro J., et al. Pemphigus vulgaris: environmental factors. Occupational, behavioral, medical, and qualitative food frequency questionnaire. Int J Dermatol 2001, 40(9):562-569.
62. Mignogna M.D., Lo Muzio L., Ruocco E. Pemphigus induction by influenza vaccination. Int J Dermatol 2000, 39(10):800.
63. Cozzani E., Cacciapuoti M., Parodi A., et al. Pemphigus following tetanus and diphtheria vaccination. Br J Dermatol 2002, 147(1):188-189.
64. Berkun Y., Mimouni D., Shoenfeld Y. Pemphigus following hepatitis B vaccination-coincidence or causality?. Autoimmunity 2005, 38(2):117-119.
65. Yalcin B., Alli N. Pemphigus vulgaris following antirabies vaccination. J Dermatol 2007, 34(10):734-735.
66. Xu F., Sternberg M.R., Kottiri B.J., et al. Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA 2006, 296(8):964-973.
67. Tufano M.A., Baroni A., Buommino E., et al. Detection of herpesvirus DNA in peripheral blood mononuclear cells and skin lesions of patients with pemphigus by polymerase chain reaction. Br J Dermatol 1999, 141(6):1033-1039.
68. Ruocco V., Wolf R., Ruocco E., et al. Viruses in pemphigus: a casual or causal relationship?. Int J Dermatol 1996, 35(11):782-784.
69. Brenner S., Sasson A., Sharon O. Pemphigus and infections. Clin Dermatol 2002, 20(2):114-118.
70. Memar O.M., Rady P.L., Goldblum R.M., et al. Human herpesvirus 8 DNA sequences in blistering skin from patients with pemphigus. Arch Dermatol 1997, 133(10):1247-1251.
71. Schlupen E.M., Wollenberg A., Hanel S., et al. Detection of herpes simplex virus in exacerbated pemphigus vulgaris by polymerase chain reaction. Dermatology 1996, 192(4):312-316.
72. Jang H.S., Oh C.K., Lim J.Y., et al. Detection of human herpesvirus 8 DNA in pemphigus and chronic blistering skin diseases. J Korean Med Sci 2000, 15(4):442-448.
73. Memar O.M., Rady P.L., Goldblum R.M., et al. Human herpesvirus-8 DNA sequences in a patient with pemphigus vulgaris, but without HIV infection or Kaposi's sarcoma. J Invest Dermatol 1997, 108(1):118-119.
74. Kalra A., Ratho R.K., Kaur I., et al. Role of herpes simplex and cytomegalo viruses in recalcitrant oral lesions of pemphigus vulgaris. Int J Dermatol 2005, 44(3):259-260.