Evolution and management of de novo neoplasm post-liver transplantation: A 20-year experience from a single European centre

Hepatology International

Volumn 5, Issue 2, 2011, Pages 707-715

  Sapisochin, Gonzalo ^a   Bilbao, Itxarone ^a   Dopazo, Cristina ^a   Castells, Luis ^a   Lázaro, Jose Luis ^a   Rodríguez, Roberto ^a   Caralt, Mireia ^a   Blanco, Laia ^a   Balsells, Joaquin ^a   Charco, Ramón ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

De novo neoplasms; Immunosuppression; Surveillance; Survival

Indexed keywords

ANTINEOPLASTIC AGENT; AZATHIOPRINE; BASILIXIMAB; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOSPORIN A; EVEROLIMUS; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISONE; RAPAMYCIN; TACROLIMUS;

ACUTE GRAFT REJECTION; ADULT; ANUS CARCINOMA; ARTICLE; BASAL CELL CARCINOMA; BLADDER CARCINOMA; BREAST ADENOCARCINOMA; CANCER INCIDENCE; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURGERY; COLON ADENOCARCINOMA; CONTINUOUS INFUSION; CONTROLLED STUDY; DE NOVO NEOPLASM; DRUG DOSE INCREASE; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GASTROINTESTINAL STROMAL TUMOR; GLOMUS TUMOR; HUMAN; KAPOSI SARCOMA; KIDNEY CARCINOMA; LARYNX CARCINOMA; LIVER CELL CARCINOMA; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LUNG ADENOCARCINOMA; LUNG SQUAMOUS CELL CARCINOMA; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEOPLASM; OROPHARYNX CARCINOMA; PANCREAS ADENOCARCINOMA; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; REPEATED DRUG DOSE; SKIN CARCINOMA; STOMACH ADENOCARCINOMA; SURVIVAL RATE; THERAPY RESISTANCE; TRANSITIONAL CELL CARCINOMA; UTERINE CERVIX CARCINOMA;

EID: 79956260821     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-010-9231-1     Document Type: Article

References (37)

1. Registro Español de Trasplante Hepático (RETH). Memoria 1984-2006. http://www.ont.es/RETH
2. I Penn 1994 The problem of cancer in organ transplant recipients: an overview Transplant Sci 4 23 32 7804694 1:STN:280:DyaK2M7gtlWhtA%3D%3D
3. JM Rabkin V De la Melena SL Orloff CL Corless HR Rosen AJ Olyaei 2001 Late mortality after orthotopic liver transplantation Am J Surg 181 475 479 11448447 10.1016/S0002-9610(01)00595-5 1:STN:280:DC%2BD3Mzpslahtw%3D%3D (Pubitemid 32614121)
4. PA Sheiner JF Magliocca CA Bodian L Kim-Schluger G Altaca SV Guarrera S Emre TM Fishbein SR Guy ME Schwartz CM Miller 2000 Long-term medical complications in patients surviving >5 years after liver transplant Transplantation 69 781 789 10755526 10.1097/00007890-200003150-00018 1:STN:280:DC%2BD3c3hs1ejsA%3D%3D (Pubitemid 30174097)
5. A Jain J Reyes R Kashyap SF Dodson AJ Demetris K Ruppert K Abu-Elmagd W Marsh J Madariaga G Mazariegos D Geller CA Bonham T Gayowski T Cacciarelli P Fontes TE Starzl JJ Fung 2000 Long-term survival after liver transplantation in 4000 consecutive patients at a single center Ann Surg 232 490 500 10998647 10.1097/00000658-200010000-00004 1:STN:280:DC%2BD3M%2Fhs1eisQ%3D%3D
6. Dopazo C, Bilbao I, Escartín A, Lázaro JL, Sapisochin G. Risk factors of late mortality following liver transplantation. In Knudsen K. H, editors. Liver Transplantation: Rejection, Therapy and Post-operative Complications; 2008
7. GH Vallejo CJ Romero JC de Vicente 2005 Incidence and risk factors for cancer after liver transplantation Crit Rev Oncol Hematol 56 87 99 15979889 10.1016/j.critrevonc.2004.12.011 (Pubitemid 41278648)
8. A Finkenstedt IW Graziadei W Oberaigner W Hilbe K Nachbaur W Mark R Margreiter W Vogel 2009 Extensive surveillance promotes early diagnosis and improved survival of de novo malignancies in liver transplantation Am J Transplant 10 2355 2361 10.1111/j.1600-6143.2009.02766.x
9. EQ Sanchez S Marubashi G Jung MF Levy RM Goldstein EP Molmenti CG Fasola TA Gonwa LW Jennings BK Brooks GB Klintmalm 2002 De novo tumors after liver transplantation: a single-institution experience Liver Transpl 8 285 291 11910575 10.1053/jlts.2002.29350 (Pubitemid 34257212)
10. I Penn 1991 The changing pattern of posttransplant malignancies Transplant Proc 23 1101 1103 1899153 1:STN:280:DyaK3M7htFCrtQ%3D%3D
11. S Jonas N Reyes U Neumann R Neuhaus WO Bechstein O Guckelberger SG Tullius S Serke P Neuhaus 1997 De novo malignancies after liver transplantation using tacrolimus-based protocols or cyclosporine-based quadruple immunosuppression with an interleukin-2 receptor antibody or antithymocyte globulin Cancer 80 1141 1150 9305716 10.1002/(SICI)1097-0142(19970915)80: 6<1141::AID-CNCR18>3.0.CO;2-8 1:CAS:528:DyaK2sXmt1yis7k%3D (Pubitemid 27427615)
12. EE Frezza JJ Fung DH van Thiel 1997 Non-lymphoid cancer after liver transplantation Hepatogastroenterology 44 1172 1181 9261620 1:STN:280: DyaK2svgsV2htA%3D%3D (Pubitemid 27326179)
13. Instituto Nacional de Estadística. Encuesta de morbilidad hospitalaria. 1999. http://www.ine.es
14. JM Valero E Rubio JM Moreno F Pons V Sanchez-Turrión V Cuervas-Mons 2003 De novo malignancies in liver transplantation Transplant Proc 35 709 711 12644105 10.1016/S0041-1345(03)00058-7 1:STN:280: DC%2BD3s7jtVKrsA%3D%3D (Pubitemid 36338126)
15. S Benlloch M Berenguer M Prieto R Moreno F San Juan M Rayón J Mir A Segura J Berenguer 2004 De novo internal neoplasms after liver transplantation: Increased risk and aggressive behavior in recent years? Am J Transplant 4 596 604 15023152 10.1111/j.1600-6143.2004.00380.x (Pubitemid 38523582)
16. M Levy L Backman B Husberg R Goldstein R McMillan J Gibbs 1993 De novo malignancy following liver transplantation: a single-center study Transplant Proc 25 1397 1399 8442153 1:STN:280:DyaK3s7ot1Srtw%3D%3D (Pubitemid 23079036)
17. EB Haagsma VE Hegens M Schaapveld AP van den Berg EG de Vries IJ Klompmaker MJ Slooff PL Jansen 2001 Increased cancer risk after liver transplantation: a population-based study J Hepatol 34 84 91 11211912 10.1016/S0168-8278(00)00077-5 1:STN:280:DC%2BD3M7ptlCnuw%3D%3D (Pubitemid 32102556)
18. I Penn 1999 Posttransplant malignancies Transplant Proc 31 1260 1261 10083562 10.1016/S0041-1345(98)01987-3 1:STN:280:DyaK1M7otlWgsw%3D%3D (Pubitemid 29127895)
19. I Penn 1990 Cancers complicating organ transplantation N Engl J Med 323 1767 1769 2247108 10.1056/NEJM199012203232510 1:STN:280:DyaK3M%2FmtFygsA%3D%3D
20. S Saigal S Norris P Muiesan M Rela N Heaton J O'Grady 2002 Evidence of differential risk for posttransplantation malignancy based on pretransplantation cause in patients undergoing liver transplantation Liver Transpl 8 482 487 12004349 10.1053/jlts.2002.32977 (Pubitemid 34520778)
21. X Xiol J Guardiola S Menéndez 2001 Risk factors for development of de novo neoplasia after liver transplantation Liver Transpl 7 971 975 11699033 10.1053/jlts.2001.28744 1:STN:280:DC%2BD3Mnks1ahsQ%3D%3D (Pubitemid 33085786)
22. AB Mithoefer S Supran RB Freeman 2002 Risk factors associated with the development of skin cancer after liver transplantation Liver Transpl 8 939 944 12360438 10.1053/jlts.2002.35551 (Pubitemid 35154026)
23. JI Herrero M Lorenzo J Quiroga B Sangro F Pardo F Rotellar J Alvarez-Cienfuegos J Prieto 2005 De novo neoplasia after liver transplantation: an analysis of risk factors and influence on survival Liver Transpl 11 89 97 15690541 10.1002/lt.20319 (Pubitemid 40124447)
24. AB Jain LD Yee MA Nalesnik A Youk G Marsh J Reyes M Zak J Rakela W Irish JJ Fung 1998 Comparative incidence of de novo nonlymphoid malignancies after liver transplantation under tacrolimus using surveillance epidemiologic end result data Transplantation 66 1193 1200 9825817 10.1097/00007890-199811150- 00014 1:STN:280:DyaK1M%2FktFWltg%3D%3D (Pubitemid 28530324)
25. YH Oo BK Gunson RJ Lancashire KK Cheng JM Neuberger 2005 Incidence of cancers following orthotopic liver transplantation in a single center: comparison with national cancer incidence rates for England and Wales Transplantation 80 759 764 16210962 10.1097/01.TP.0000173775.16579.18 (Pubitemid 41443757)
26. H Higashi K Yanaga JW Marsh A Tzakis S Kakizoe TE Starzl 1990 Development of colon cancer after liver transplantation for primary sclerosing cholangitis associated with ulcerative colitis Hepatology 11 477 480 2312061 10.1002/hep.1840110320 1:STN:280:DyaK3c7osFGrsw%3D%3D (Pubitemid 20120003)
27. SJ Knechtle AM D'Alessandro BA Harms JD Pirsch FO Belzer M Kalayoglu 1995 Relationships between sclerosing cholangitis, inflammatory bowel disease, and cancer in patients undergoing liver transplantation Surgery 118 615 620 7570313 10.1016/S0039-6060(05)80026-1 1:STN:280:DyaK28%2Fgs1elsQ%3D%3D
28. KJ Lewin 1997 Post-transplant lymphoproliferative disorders Pathol Oncol Res 3 177 182 18470727 10.1007/BF02899918 1:STN:280:DC%2BD1czgvVagtA%3D%3D
29. F Aberg E Pukkala K Hockerstedt R Sankila H Isoniemi 2008 Risk of malignant neoplasms after liver transplantation: a population based study Liver Transpl 14 1428 1436 18825704 10.1002/lt.21475
30. Y Jiang PJ Villeneuve SS Fenton DE Schaubel L Lilly Y Mao 2008 Liver transplantation and subsequent risk of cancer: findings from a Canadian cohort study Liver Transpl 14 1588 1597 18975293 10.1002/lt.21554
31. MV Catalina A de Diego A Garcia-Sánchez M Escudero M Salcedo R Bañares G Clemente 2003 Characterization of de novo malignancies in liver transplantation Gastroenterol Hepatol 26 57 63 12570889 10.1157/13050354 1:STN:280:DC%2BD3s%2FmtVOltw%3D%3D (Pubitemid 37174037)
32. HM Kauffman WS Cherikh MA McBride Y Cheng DW Hanto 2006 Post-transplant de novo malignancies in renal transplant recipients: the past and present Transpl Int 19 607 620 16827677 10.1111/j.1432-2277.2006.00330.x
33. BK Law 2005 Rapamycin: an anti-cancer immunosuppressant? Crit Rev Oncol Hematol 56 47 60 16039868 10.1016/j.critrevonc.2004.09.009 (Pubitemid 41278645)
34. FL Luan M Hojo M Maluccio K Yamaji M Suthanthiran 2002 Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy Transplantation 73 1565 1572 12042641 10.1097/00007890-200205270-00008 1:CAS:528:DC%2BD38XkvFGmtbY%3D (Pubitemid 34568667)
35. HM Kauffman WS Cherikh Y Cheng DW Hanto BD Kahan 2005 Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies Transplantation 80 883 889 16249734 10.1097/01.TP.0000184006.43152.8D 1:CAS:528:DC%2BD2MXhtFGhs7fJ (Pubitemid 41552882)
36. JM Campistol A Gutierrez-Dalmau JV Torregrosa 2004 Conversion to sirolimus: a successful treatment for post-transplantation Kaposi's sarcoma Transplantation 77 760 762 15021843 10.1097/01.TP.0000115344.18025.0B (Pubitemid 38366986)
37. A Monaco 2009 The role of mTOR inhibitors in the management of post-transplant malignancy Transplantation 87 157 163 19155967 10.1097/TP.0b013e318193886e 1:CAS:528:DC%2BD1MXotVansA%3D%3D