Rhinovirus-associated wheeze during infancy and asthma development

Current Respiratory Medicine Reviews

Volumn 7, Issue 3, 2011, Pages 160-166

  Jartti, Tuomas ^a   Gern, James E ^b  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Asthma; Bronchiolitis; Child; Infant; Prognosis; Respiratory syncytial virus; Rhinovirus; Wheezing

Indexed keywords

BETA INTERFERON; CORTICOSTEROID; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 13; INTERLEUKIN 29; PREDNISOLONE;

ALLERGIC ASTHMA; ARTICLE; ATOPY; CELLULAR IMMUNITY; CHILDHOOD DISEASE; CORTICOSTEROID THERAPY; CYTOKINE RESPONSE; DISEASE ASSOCIATION; DISEASE COURSE; ECZEMA; HUMAN; HUMAN RHINOVIRUS; INFANT DISEASE; INFECTION RISK; INFECTION SENSITIVITY; NONHUMAN; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; RHINOVIRUS INFECTION; SENSITIZATION; VIRAL BRONCHIOLITIS; VIRUS DETECTION; VIRUS IMMUNITY; WHEEZING;

EID: 79956260267     PISSN: 1573398X     EISSN: 18756387     Source Type: Journal    
DOI: 10.2174/157339811795589423     Document Type: Article

References (117)

1. Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD. Tucson children's respiratory study: 1980 to present. J Allergy Clin Immunol 2003; 111: 661-75.
2. Polk S, Sunyer J, Muñoz-Ortiz L, et al. A prospective study of Fel d1 and Der p1 exposure in infancy and childhood wheezing. Am J Respir Crit Care Med 2004; 170: 273-8.
3. Sandin A, Bjorksten B, Braback L. Development of atopy and wheezing symptoms in relation to heredity and early pet keeping in a Swedish birth cohort. Pediatr Allergy Immunol 2004; 15: 316-22.
4. Matricardi PM, Illi S, Gruber C, et al. Wheezing in childhood: incidence, longitudinal patterns and factors predicting persistence. Eur Respir J 2008; 32: 585-92.
5. Scottish Intercollegiate Guidelines Network. Bronchiolitis in children. A national clinical guideline. November2006. http://www.sign.ac.uk/pdf/sign91.pdf.
6. Murray CS, Poletti G, Kebadze T, et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax 2006; 61: 376-82.
7. Turner SW, Palmer LJ, Rye PJ, et al. Infants with flow limitation at 4 weeks: outcome at 6 and 11 years. Am J Respir Crit Care Med 2002; 165: 1294-8.
8. Turner SW, Palmer LJ, Rye PJ, et al. The relationship between infant airway function, childhood airway responsiveness, and asthma. Am J Respir Crit Care Med 2004; 169: 921-7.
9. Copenhaver CC, Gern JE, Li Z, et al. Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life. Am J Respir Crit Care Med 2004; 170: 175-80.
10. Heymann PW, Platts-Mills TA, Johnston SL. Role of viral infections, atopy and antiviral immunity in the etiology of wheezing exacerbations among children and young adults. Pediatr Infect Dis J 2005; 24: S217-22, discussion S220-1.
11. Singh AM, Moore PE, Gern JE, Lemanske RF Jr, Hartert TV. Bronchiolitis to asthma: a review and call for studies of gene-virus interactions in asthma causation. Am J Respir Crit Care Med 2007;175: 108-19.
12. Juntti H, Osterlund P, Kokkonen J, et al. Cytokine responses in cord blood predict the severity of later respiratory syncytial virus infection. J Allergy Clin Immunol 2009; 124: 52-8.
13. Scagnolari C, Midulla F, Trombetti S, et al. Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis. Exp Biol Med (Maywood) 2007; 232: 1355-9.
14. Miyairi I, De Vincenzo JP. Human genetic factors and respiratory syncytial virus disease severity. Clin Microbiol Rev 2008; 21: 686-703.
15. Helminen M, Nuolivirta K, Virta M, et al. IL-10 gene polymorphism at-1082 A/G is associated with severe rhinovirus bronchiolitis in infants. Pediatr Pulmonol 2008; 43: 391-5.
16. Forton JT, Rowlands K, Rockett K, et al. Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster. Thorax 2009; 64: 345-52.
17. Koehoorn M, Karr CJ, Demers PA, Lencar C, Tamburic L, Brauer M. Descriptive epidemiological features of bronchiolitis in a population-based cohort. Pediatrics 2008; 122: 1196-203.
18. Wright AL, Holberg C, Martinez FD, Taussig LM. Relationship of parental smoking to wheezing and nonwheezing lower respiratory tract illnesses in infancy. Group Health Medical Associates. J Pediatr 1991; 118: 207-14.
19. Carroll KN, Gebretsadik T, Griffin MR, et al. Maternal asthma and maternal smoking are associated with increased risk of bronchiolitis during infancy. Pediatrics 2007; 119: 1104-12.
20. Håberg SE, Stigum H, Nystad W, Nafstad P. Effects of pre-and postnatal exposure to parental smoking on early childhood respiratory health. Am J Epidemiol 2007; 166: 679-86.
21. Ryan PH, LeMasters G, Biagini J, et al. Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic. J Allergy Clin Immunol 2005; 116: 279-84.
22. Emenius G, Svartengren M, Korsgaard J, et al. Indoor exposures and recurrent wheezing in infants: a study in the BAMSE cohort. Acta Paediatr 2004; 93: 899-905.
23. Kummeling I, Stelma FF, Dagnelie PC, et al. Early life exposure to antibiotics and the subsequent development of eczema, wheeze, and allergic sensitization in the first 2 years of life: the KOALA Birth Cohort Study. Pediatrics 2007; 119: e225-31.
24. Linneberg A, Simonsen JB, Petersen J, et al. Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology. J Allergy Clin Immunol 2006; 117: 184-89.
25. Wright AL, Taussig LM, Ray CG, Harrison HR, Holberg CJ. The Tucson Children's Respiratory Study. II. Lower respiratory tract illness in the first year of life. Am J Epidemiol 1989; 129: 1232-46.
26. von Linstow ML, Holst KK, Larsen K, Koch A, Andersen PK, Høgh B. Acute respiratory symptoms and general illness during the first year of life: a population-based birth cohort study. Pediatr Pulmonol 2008; 43: 584-93.
27. Korppi M, Halonen P, Kleemola M, Launiala K. Viral findings in children under the age of two years with expiratory difficulties. Acta Paediatr Scand 1986; 75: 457-64.
28. Reijonen T, Korppi M, Pitkakangas S, Tenhola S, Remes K. The clinical efficacy of nebulized racemic epinephrine and albuterol in acute bronchiolitis. Arch Pediatr Adolesc Med 1995; 149: 686-92.
29. Oddy WH, Sly PD, de Klerk NH, et al. Breast feeding and respiratory morbidity in infancy: a birth cohort study. Arch Dis Child 2003; 88: 224-8.
30. Bardin PG, Fraenkel DJ, Sanderson G, et al. Amplified rhinovirus colds in atopic subjects. Clin Exp Allergy 1994; 24: 457-64.
31. Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL. A defective type 1 response to rhinovirus in atopic asthma. Thorax 2002; 57: 328-32.
32. Wark PA, Johnston SL, Bucchieri F, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005; 201: 937-47.
33. Contoli M, Message SD, Laza-Stanca V, et al. Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med 2006; 12: 1023-6.
34. Gern JE, Brooks GD, Meyer P, et al. Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life. J Allergy Clin Immunol 2006; 117: 72-8.
35. Stern DA, Guerra S, Halonen M, Wright AL, Martinez FD. Low IFN-gamma production in the first year of life as a predictor of wheeze during childhood. J Allergy Clin Immunol 2007; 120: 835-41.
36. Message SD, Laza-Stanca V, Mallia P, et al. Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. Proc Natl Acad Sci USA 2008; 105: 13562-7.
37. Gern JE. Rhinovirus and the initiation of asthma. Curr Opin Allergy Clin Immunol 2009; 9: 73-8.
38. Allander T, Jartti T, Gupta S, et al. Human bocavirus and acute wheezing in children. Clin Infect Dis 2007; 44: 904-10.
39. Lemanske RF Jr, Jackson DJ, Gangnon RE, et al. Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol 2005; 116: 571-7.
40. Jartti T, Lehtinen P, Vuorinen T, Ruuskanen O. Bronchiolitis: age and previous wheezing episodes are linked to viral etiology and atopic characteristics. Pediatr Infect Dis J 2009; 28: 311-7.
41. Rakes GP, Arruda E, Ingram JM, et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses. Am J Respir Crit Care Med 1999; 159:785-90.
42. Johnston SL, Pattemore PK, Sanderson G, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 1995; 310: 1225-9.
43. Jartti T, Lee WM, Pappas T, Evans M, Lemanske RF Jr, Gern JE. Serial viral infections in infants with recurrent respiratory illnesses. Eur Respir J 2008; 32: 314-20.
44. Monto AS, Bryan ER, Ohmit S. Rhinovirus infections in Tecumseh, Michigan: frequency of illness and number of serotypes. J Infect Dis 1987; 156: 43-9.
45. Hamparian VV, Colonno RJ, Cooney MK, et al. A collaborative report: rhinoviruses-extension of the numbering system from 89 to 100. Virology 1987; 159: 191-2.
46. Lamson D, Renwick N, Kapoor V, et al. Mass Tag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during 2004-2005. J Infect Dis 2006; 194: 1398-402.
47. Kistler A, Avila PC, Rouskin S, et al. Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human corona virus and human rhinovirus diversity. J Infect Dis 2007; 196: 817-25.
48. Lee WM, Kiesner C, Pappas T, et al. A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants. PLoS One 2007; 2: e966.
49. Jartti T, Jartti L, Peltola V, Waris M, Ruuskanen O. Identification of respiratory viruses in asymptomatic subjects: asymptomatic respiratory viral infections. Pediatr Infect Dis J 2008; 27: 1103-7.
50. Heymann PW, Carper HT, Murphy DD, et al. Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing. J Allergy Clin Immunol 2004; 114: 239-47.
51. Garbino J, Gerbase MW, Wunderli W, et al. Lower respiratory viral illnesses: improved diagnosis by molecular methods and clinical impact. Am J Respir Crit Care Med 2004; 170: 1197-203.
52. Arnold JC, Singh KK, Spector SA, Sawyer MH. Undiagnosed respiratory viruses in children. Pediatrics 2008; 121: e631-7.
53. van Gageldonk-Lafeber AB, Heijnen ML, Bartelds AI, et al. A case-control study of acute respiratory tract infection in general practice patients in The Netherlands. Clin Infect Dis 2005; 41: 490-7.
54. Malmström K, Pitkäranta A, Carpen O, et al. Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms. J Allergy Clin Immunol 2006; 118: 591-6.
55. Jartti T, Waris M, Niesters HG, Allander T, Ruuskanen O. Respiratory viruses and acute asthma in children. J Allergy Clin Immunol 2007; 120: 216.
56. Kusel MM, de Klerk NH, Holt PG, Kebadze T, Johnston SL, Sly PD. Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study. Pediatr Infect Dis J 2006; 25: 680-6.
57. Khetsuriani N, Kazerouni NN, Erdman DD, et al. Prevalence of viral respiratory tract infections in children with asthma. J Allergy Clin Immunol 2007; 119: 314-21.
58. Gern JE, Galagan DM, Jarjour NN, Dick EC, Busse WW. Detection of rhinovirus RNA in lower airway cells during experimentally induced infection. Am J Respir Crit Care Med 1997; 155: 1159-61.
59. Papadopoulos NG, Sanderson G, Hunter J, Johnston SL. Rhinoviruses replicate effectively at lower airway temperatures. J Med Virol 1999; 58: 100-4.
60. Kaiser L, Aubert JD, Pache JC, et al. Chronic rhinoviral infection in lung transplant recipients. Am J Respir Crit Care Med 2006; 174: 1392-9.
61. Jartti T, Lehtinen P, Vuorinen T, Koskenvuo M, Ruuskanen O. Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children. J Med Virol 2004; 72: 695-9.
62. Winther B, Hayden FG, Hendley JO. Picornavirus infections in children diagnosed by RT-PCR during longitudinal surveillance with weekly sampling: Association with symptomatic illness and effect of season. J Med Virol 2006; 78: 644-50.
63. Peltola V, Waris M, Osterback R, Susi P, Ruuskanen O, Hyypiä T. Rhinovirus transmission within families with children: incidence of symptomatic and asymptomatic infections. J Infect Dis 2008; 197:382-9.
64. Jartti T, Paul-Anttila M, Lehtinen P, et al. Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing: an observational study. Respir Res 2009; 10: 85.
65. Winther B, Alper CM, Mandel EM, Doyle WJ, Hendley JO. Temporal relationships between colds, upper respiratory viruses detected by polymerase chain reaction, and otitis media in young children followed through a typical cold season. Pediatrics 2007; 119: 1069-75.
66. Winther B, Gwaltney JM Jr, Mygind N, Turner RB, Hendley JO. Sites of rhinovirus recovery after point inoculation of the upper airway. JAMA 1986; 256: 1763-7.
67. Hyypiä T, Puhakka T, Ruuskanen O, Mäkelä M, Arola A, Arstila P. Molecular diagnosis of human rhinovirus infections: comparison with virus isolation. J Clin Microbiol 1998; 36: 2081-3.
68. Lopez-Souza N, Favoreto S, Wong H, et al. In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects. J Allergy Clin Immunol 2009;123: 1384-90.
69. Bochkov YA, Hanson KM, Keles S, Brockman-Schneider RA, Jarjour NN, Gern JE. Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma. Mucosal Immunol 2010; 3: 69-80.
70. Lachowicz-Scroggins ME, Boushey HA, Finkbeiner WE, Widdicombe JH. Interleukin-13 induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection. Am J Respir Cell Mol Biol 2010 Jan 15. [Epub ahead of print]
71. DeMore JP, Weisshaar EH, Vrtis RF, et al. Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16. J Allergy Clin Immunol 2009; 124:245-52.
72. Kusel MM, de Klerk NH, Kebadze T, et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 2007;119: 1105-10.
73. Jackson DJ, Gangnon RE, Evans MD, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008; 178: 667-72.
74. Korppi M, Kotaniemi-Syrjänen A, Waris M, Vainionpää R, Reijonen TM. Rhinovirus-associated wheezing in infancy: comparison with respiratory syncytial virus bronchiolitis. Pediatr Infect Dis J 2004; 23: 995-9.
75. Jartti T, Lehtinen P, Vanto T, et al. Evaluation of the efficacy of prednisolone in early wheezing induced by rhinovirus or respiratory syncytial virus. Pediatr Infect Dis J 2006; 25: 482-8.
76. Heymann PW, Rakes GP, Hogan AD, Ingram JM, Hoover GE, Platts-Mills TA. Assessment of eosinophils, viruses and IgE antibody in wheezing infants and children. Int Arch Allergy Immunol 1995; 107: 380-2.
77. Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008; 63: S8-160.
78. Zambrano JC, Carper HT, Rakes GP, et al. Experimental rhinovirus challenges in adults with mild asthma: response to infection in relation to IgE. J Allergy Clin Immunol 2003; 111:1008-16.
79. Hyvärinen MK, Kotaniemi-Syrjänen A, Reijonen TM, Korhonen K, Korppi MO. Teenage asthma after severe early childhood wheezing: an 11-year prospective follow-up. Pediatr Pulmonol 2005; 40: 316-23.
80. Lehtinen P, Ruohola A, Vanto T, Vuorinen T, Ruuskanen O, Jartti T. Prednisolone reduces recurrent wheezing after a first wheezing episode associated with rhinovirus infection or eczema. J Allergy Clin Immunol 2007; 119: 570-5.
81. Bianco A, Sethi SK, Allen JT, Knight RA, Spiteri MA. Th2 cytokines exert a dominant influence on epithelial cell expression of the major group human rhinovirus receptor, ICAM-1. Eur Respir J 1998; 12: 619-26.
82. Bianco A, Whiteman SC, Sethi SK, Allen JT, Knight RA, Spiteri MA. Expression of intercellular adhesion molecule-1 (ICAM-1) in nasal epithelial cells of atopic subjects: a mechanism for increased rhinovirus infection? Clin Exp Immunol 2000; 121: 339-45.
83. Kim WK, Olenec JP, Lee WM, et al. Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol 2010, 125(5): 1001-6.
84. de Kluijver J, Evertse CE, Sont JK, et al. Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure? Am J Respir Crit Care Med 2003; 168: 1174-80.
85. Jakiela B, Brockman-Schneider R, Amineva S, Lee WM, Gern JE. Basal cells of differentiated bronchial epithelium are more susceptible to rhinovirus infection. Am J Respir Cell Mol Biol 2008; 38: 517-23.
86. Lopez-Souza N, Dolganov G, Dubin R, et al. Resistance of differentiated human airway epithelium to infection by rhinovirus. Am J Physiol Lung Cell Mol Physiol 2004; 286: L373-81.
87. Lai CK, Beasley R, Crane J, et al. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009; 64: 476-83.
88. Martinez FD, Wright AL, Taussig LM, et al. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332: 133-8.
89. Kotaniemi-Syrjänen A, Reijonen TM, Korhonen K, Korppi M. Wheezing requiring hospitalization in early childhood: Predictive factors for asthma in a six-year follow-up. Pediatr Allergy Immunol 2002; 13: 418-25.
90. Sherriff A, Peters TJ, Henderson J, Strachan D; ALSPAC Study Team. Avon Longitudinal Study of Parents and Children. Risk factor associations with wheezing patterns in children followed longitudinally from birth to 3(1/2) years. Int J Epidemiol 2001; 30:1473-84.
91. Illi S, von Mutius E, Lau S, et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 2006; 368: 763-70.
92. Carroll KN, Wu P, Gebretsadik T, et al. The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma. J Allergy Clin Immunol 2009; 123: 1055-61.
93. Korppi M, Kuikka L, Reijonen T, et al. Bronchial asthma and hyperreactivity after early childhood bronchiolitis or pneumonia. An 8-year follow-up study. Arch Pediatr Adolesc Med 1994; 148:1079-84.
94. Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 2000;161: 1501-7.
95. Henderson J, Hilliard TN, Sherriff A, Stalker D, Al Shammari N, Thomas HM. Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study. Pediatr Allergy Immunol 2005; 16:386-92.
96. Kotaniemi-Syrjänen A, Laatikainen A, Waris M, Reijonen TM, Vainionpää R, Korppi M. Respiratory syncytial virus infection in children hospitalized for wheezing: virus-specific studies from infancy to preschool years. Acta Paediatr 2005; 94: 159-65.
97. Valkonen H, Waris M, Ruohola A, Ruuskanen O, Heikkinen T. Recurrent wheezing after respiratory syncytial virus or non-respiratory syncytial virus bronchiolitis in infancy: a 3-year follow-up. Allergy 2009; 64: 1359-65.
98. Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000; 162: 1403-6.
99. Guilbert TW, Morgan WJ, Zeiger RS, et al. Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol 2004;114: 1282-7.
100. Saga R, Mochizuki H, Tokuyama K, Morikawa A. Relationship between bronchial hyperresponsiveness and development of asthma in wheezy infants. Chest 2001; 119: 685-90.
101. Turner SW, Young S, Goldblatt J, Landau LI, Le Souëf PN. Childhood asthma and increased airway responsiveness: a relationship that begins in infancy. Am J Respir Crit Care Med 2009; 179: 98-104.
102. Wennergren G, Amark M, Amark K, Oskarsdottir S, Sten G, Redfors S. Wheezing bronchitis reinvestigated at the age of 10 years. Acta Paediatr 1997; 86: 351-5.
103. Cook DG, Strachan DP, Carey IM. Health effects of passive smoking. Thorax 1999; 54: 469.
104. Moshammer H, Hoek G, Luttmann-Gibson H, et al. Parental smoking and lung function in children: an international study. Am J Respir Crit Care Med 2006; 173: 1255-63.
105. Piippo-Savolainen E, Remes S, Kannisto S, Korhonen K, Korppi M. Early predictors for adult asthma and lung function abnormalities in infants hospitalized for bronchiolitis: a prospective 18- to 20-year follow-up. Allergy Asthma Proc 2006; 27: 341-9.
106. Goksör E, Amark M, Alm B, Gustafsson PM, Wennergren G. The impact of pre- and post-natal smoke exposure on future asthma and bronchial hyper-responsiveness. Acta Paediatr 2007; 96: 1030-5.
107. Apelberg BJ, Aoki Y, Jaakkola JJ. Systematic review: Exposure to pets and risk of asthma and asthma-like symptoms. J Allergy Clin Immunol 2001; 107: 455-60.
108. Remes ST, Castro-Rodriguez JA, Holberg CJ, Martinez FD, Wright AL. Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy. J Allergy Clin Immunol 2001;108: 509-15.
109. Ownby DR, Johnson CC, Peterson EL. Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA 2002; 288: 963-72.
110. Ownby DR, Johnson CC. Does exposure to dogs and cats in the first year of life influence the development of allergic sensitization? Curr Opin Allergy Clin Immunol 2003; 3: 517-22.
111. von Mutius E. Asthma and allergies in rural areas of Europe. Proc Am Thorac Soc 2007; 4: 212-6.
112. Piippo-Savolainen E, Korppi M. Wheezy babies-wheezy adults? Review on long-term outcome until adulthood after early childhood wheezing. Acta Paediatr 2008; 97: 5-11.
113. Kotaniemi-Syrjänen A, Vainionpää R, Reijonen TM, Waris M, Korhonen K, Korppi M. Rhinovirus-induced wheezing in infancy-the first sign of childhood asthma? J Allergy Clin Immunol 2003;111: 66-71.
114. Roosevelt G, Sheehan K, Grupp Phelan J, Tanz RR, Listernick R. Dexamethasone in bronchiolitis: a randomised controlled trial. Lancet 1996; 348: 292-5.
115. De Boeck K, Van der Aa N, Van Lierde S, Corbeel L, Eeckels R. Respiratory syncytial virus bronchiolitis: a double-blind dexamethasone efficacy study. J Pediatr 1997; 131: 919-21.
116. Bülow SM, Nir M, Levin E, et al. Prednisolone treatment of respiratory syncytial virus infection: a randomized controlled trial of 147 infants. Pediatrics 1999; 104: e77.
117. Jackson DL, Guilbert TW, Evans MD, et al. Inclusion of rhinovirus wheezing history in early life improves the sensiticity of the modified asthma predictive index (mAPI). J Allergy Clin Immunol 2009; 123: S82.