When should nebulized hypertonic saline solution be used in the treatment of bronchiolitis?

Paediatrics and Child Health

Volumn 16, Issue 3, 2011, Pages 157-158

  Hom, Jeffrey ^a   Fernandes, Ricardo M ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOSPITAL DE SANTA MARIA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BRONCHODILATING AGENT; SALBUTAMOL; SODIUM CHLORIDE; TERBUTALINE;

BRONCHIOLITIS; BRONCHOSPASM; CANADA; CHILD CARE; CHILD HEALTH; CHILD HOSPITALIZATION; EMERGENCY WARD; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; LUNG FUNCTION; NEBULIZATION; REVIEW; SCORING SYSTEM; TREATMENT OUTCOME;

EID: 79956258711     PISSN: 12057088     EISSN: None     Source Type: Journal    
DOI: 10.1093/pch/16.3.157     Document Type: Review

References (17)

1. Simoes EAF, Carbonell-Estrany X. Impact of severe disease caused by respiratory synctial virus in children living in developed countries. Pediatr Inf Dis J 2003;22(Suppl):S13-20. (Pubitemid 36230941)
2. King VJ, Viswanathan M, Bordley C, et al. Pharmacologic treatment of bronchiolitis in infants and children: A systematic review. Arch Pediatr Adolesc Med 2004;158:127-37. (Pubitemid 38173966)
3. Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP. Nebulized hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev 2008;4:CD006458.
4. Sarrell EM, Tal G, Witzling M, et al. Nebulized 3% hypertonic saline solution treatment in ambulatory children with viral bronchiolitis decreases symptoms. Chest 2002;122:2015-20. (Pubitemid 36051138)
5. Mandelberg A, Tal G, Witzling M, et al. Nebulized 3% hypertonic saline solution treatment in hospitalized infants with viral bronchiolitis. Chest 2003;123:481-7. (Pubitemid 36269434)
6. Tal G, Cesar K, Oron A, Houri S, Ballin A, Mandelberg A. Hypertonic saline/epinephrine treatment in hospitalized infants with viral bronchiolitis reduces hospitalization stay: 2 years experience. IMAJ 2006;8:169-73.
7. Kuzik BA, Al Qadhi SA, Kent S, et al. Nebulized hypertonic saline in the treatment of viral bronchiolitis in infants. J Pediatr 2007;151:266-70.
8. Luo Z, Liu E, Luo J, et al. Nebulized hypertonic saline/salbutamol solution treatment in hospitalized children with mild to moderate bronchiolitis. Pediatr Int 2010;52:199-202.
9. Grewal S, Ali S, McConnell DW, Vandermeer B, Klassen TP. A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department. Arch Pediatr Adolesc Med 2009;163:1007-17.
10. Anil AB, Anil M, Saglam AB, Cetin N, Bal A, Aksu N. High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis. Pediatr Pulmonol 2010;45:41-7.
11. Plint AC, Johnson DW, Patel H, et al. Epinephrine and dexamethasone in children with bronchiolitis. N Engl J Med 2009;360:2079-89.
12. Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, Anderson LJ. Bronchiolitis-associated hospitalizations among US children, 1980-1996. JAMA 1999;282:1440-6. (Pubitemid 29493797)
13. Langley J-M, LeBlanc J-C, Smith B, Wang E-E. Increasing incidence of hospitalization for bronchiolitis among Canadian children, 1980-2000. J Infect Dis 2003;188:1764-7. (Pubitemid 38010688)
14. Wark P, McDonald VM. Nebulised hypertonic saline for cystic fibrosis. Cochrane Database Syst Rev 2009;2:CD001506.
15. Mandelberg A, Amirav I. Hypertonic saline or high volume normal saline for viral bronchiolitis: Mechanisms and rationale. Pediatr Pulmonol 2010;45:36-40.
16. Bialy L, Smith M, Bourke T, Becker L. The Cochrane Library and bronchiolitis: An umbrella review. Evidence-Based Child Health: A Cochrane Review Journal 2006;1:939-47.
17. Dellon EP, Donaldson SH, Johnson R, Davis SD. Safety and tolerability of inhaled hypertonic saline in young children with cystic fibrosis. Pediatr Pulmonol 2008;43:1100-6.