Epithelial Membrane Protein 1 Inhibits Human Spinal Chondrocyte Differentiation

Anatomical Record

Volumn 294, Issue 6, 2011, Pages 1015-1024

  Li, Zhi Yong ^a   Xiong, Shao Hu ^a   Hu, Ming ^b   Zhang, Chuan Sen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b 309TH HOSPITAL OF PLA   (China)

Author keywords

Chondrocytes; Differentiation; Epithelial membrane protein 1; Intervertebral disc development

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; AGGRECAN; COLLAGEN TYPE 10; EPITHELIAL MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; TESTIS DETERMINING FACTOR; TRANSCRIPTION FACTOR SOX; UNCLASSIFIED DRUG;

ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE SILENCING; GROWTH PLATE; HUMAN; HUMAN CELL; LENTIVIRINAE; NERVE CELL INHIBITION; NUCLEUS PULPOSUS; OSSIFICATION; PRIORITY JOURNAL;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHONDROCYTES; CHONDROGENESIS; GENE KNOCKDOWN TECHNIQUES; GROWTH INHIBITORS; HUMANS; HYPERTROPHY; INTERVERTEBRAL DISK; NEOPLASM PROTEINS; RECEPTORS, CELL SURFACE; SPINAL CORD;

LENTIVIRUS;

EID: 79956258262     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.21395     Document Type: Article

References (37)

1. Archer CW, Rooney P, Wolpert L. 1982. Cell shape and cartilage differentiation of early chick limb bud cells in culture. Cell Differ 11: 245-251.
2. Ben-Porath I, Yanuka O, Benvenisty N. 1999. The tmp gene, encoding a membrane protein, is a c-Myc target with a tumorigenic activity. Mol Cell Biol 19: 3529-3539.
3. Castagnola P, Dozin B, Moro G, Cancedda R. 1988. Changes in the expression of collagen genes show two stages in chondrocyte differentiation in vitro. J Cell Biol 106: 461-467.
4. Coverley D, Laman H, Laskey RA. 2002. Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat Cell Biol 4: 523-528.
5. DeLise AM, Tuan RS. 2002. Alterations in the spatiotemporal expression pattern and function of N-cadherin inhibit cellular condensation and chondrogenesis of limb mesenchymal cells in vitro. J Cell Biochem 87: 342-359.
6. Descalzi Cancedda F, Gentili C, Manduca P, Cancedda R. 1992. Hypertrophic chondrocytes undergo further differentiation in culture. J Cell Biol 117: 427-435.
7. Fukada K, Shibata S, Suzuki S, Ohya K, Kuroda T. 1999. In situ hybridisation study of type I, II, X collagens and aggrecan mRNas in the developing condylar cartilage of fetal mouse mandible. J Anat 195 (Part 3): 321-329.
8. Garimella R, Bi X, Camacho N, Sipe JB, Anderson HC. 2004. Primary culture of rat growth plate chondrocytes: an in vitro model of growth plate histotype, matrix vesicle biogenesis and mineralization. Bone 34: 961-970.
9. Gerstenfeld LC, Shapiro FD. 1996. Expression of bone-specific genes by hypertrophic chondrocytes: implication of the complex functions of the hypertrophic chondrocyte during endochondral bone development. J Cell Biochem 62: 1-9.
10. Gibson G, Lin DL, Roque M. 1997. Apoptosis of terminally differentiated chondrocytes in culture. Exp Cell Res 233: 372-382.
11. Glowacki J, Trepman E, Folkman J. 1983. Cell shape and phenotypic expression in chondrocytes. Proc Soc Exp Biol Med 172: 93-98.
12. Hirsch MS, Cook SC, Killiany R, Hartford Svoboda KK. 1996. Increased cell diameter precedes chondrocyte terminal differentiation, whereas cell-matrix attachment complex proteins appear constant. Anat Rec 244: 284-296.
13. Hu M, Zhang CS, Chen DY. 2004. Analysis of Gene expression pattern of lumbar intervertebral disc degeneration in human. Chin J Anat 27: 348-351.
14. Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD. 2005. Perp is a p63-regulated gene essential for epithelial integrity. Cell 120: 843-856.
15. James CG, Appleton CT, Ulici V, Underhill TM, Beier F. 2005. Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy. Mol Biol Cell 16: 5316-5333.
16. Karsenty G, Wagner EF. 2002. Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2: 389-406.
17. Kim KW, Lim TH, Kim JG, Jeong ST, Masuda K, An HS. 2003. The origin of chondrocytes in the nucleus pulposus and histologic findings associated with the transition of a notochordal nucleus pulposus to a fibrocartilaginous nucleus pulposus in intact rabbit intervertebral discs. Spine (Phila Pa 1976) 28: 982-990.
18. Kronenberg HM. 2003. Developmental regulation of the growth plate. Nature 423: 332-336.
19. Lee HS, Sherley JL, Chen JJ, Chiu CC, Chiou LL, Liang JD, Yang PC, Huang GT, Sheu JC. 2005. EMP-1 is a junctional protein in a liver stem cell line and in the liver. Biochem Biophys Res Commun 334: 996-1003.
20. Lobsiger CS, Magyar JP, Taylor V, Wulf P, Welcher AA, Program AE, Suter U. 1996. Identification and characterization of a cDNA and the structural gene encoding the mouse epithelial membrane protein-1. Genomics 36: 379-387.
21. Loty S, Sautier JM, Forest N. 2000. Phenotypic modulation of nasal septal chondrocytes by cytoskeleton modification. Biorheology 37: 117-125.
22. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M. 2008. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol 40: 46-62.
23. Muir H. 1995. The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules. Bioessays 17: 1039-1048.
24. Nowak M, Koster C, Hammerschmidt M. 2005. Perp is required for tissue-specific cell survival during zebrafish development. Cell Death Differ 12: 52-64.
25. Oberlender SA, Tuan RS. 1994. Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis. Development 120: 177-187.
26. Ruegg CL, Wu HY, Fagnoni FF, Engleman EG, Laus R. 1996. B4B, a novel growth-arrest gene, is expressed by a subset of progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain. J Immunol 157: 72-80.
27. Schiemann S, Valentine M, Weidle UH. 1997. Assignment of the human progression associated protein (PAP) to chromosome 12p12.3. Anticancer Res 17: 4281-4285.
28. Shum L, Nuckolls G. 2002. The life cycle of chondrocytes in the developing skeleton. Arthritis Res 4: 94-106.
29. Sunters A, Thomas DP, Yeudall WA, Grigoriadis AE. 2004. Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene: induction of cyclin A and enhanced CDK2 activity. J Biol Chem 279: 9882-9891.
30. Tallheden T, Karlsson C, Brunner A, Van Der Lee J, Hagg R, Tommasini R, Lindahl A. 2004. Gene expression during redifferentiation of human articular chondrocytes. Osteoarthritis Cartilage 12: 525-535.
31. Taylor V, Welcher AA, Program AE, Suter U. 1995. Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family. J Biol Chem 270: 28824-28833.
32. Urban JPG, Roberts S, Ralphs JR. 2000. The nucleus of the intervertebral disc from development to degeneration. Am Zool 40: 53-61.
33. van Dartel M, Hulsebos TJ. 2004a. Amplification and overexpression of genes in 17p11.2 ̃ p12 in osteosarcoma. Cancer Genet Cytogenet 153: 77-80.
34. van Dartel M, Hulsebos TJ. 2004b. Characterization of PMP22 expression in osteosarcoma. Cancer Genet Cytogenet 152: 113-118.
35. Walmsley R. 1953. The development and growth of the intervertebral disc. Edinb Med J 60: 341-364.
36. Widelitz RB, Jiang TX, Murray BA, Chuong CM. 1993. Adhesion molecules in skeletogenesis. II. Neural cell adhesion molecules mediate precartilaginous mesenchymal condensations and enhance chondrogenesis. J Cell Physiol 156: 399-411.
37. Wilson HL, Wilson SA, Surprenant A, North RA. 2002. Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. J Biol Chem 277: 34017-34023.