Effects of mosapride citrate, a 5-HT4-receptor agonist, on gastric distension-induced visceromotor response in conscious rats

Journal of Pharmacological Sciences

Volumn 116, Issue 1, 2011, Pages 47-53

  Seto, Yasuhiro ^a   Yoshida, Naoyuki ^a   Kaneko, Hiroshi ^b  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Functional dyspepsia; Gastric distension; Mosapride citrate; Visceral pain

Indexed keywords

DRUG METABOLITE; GRANISETRON; ITOPRIDE; MORPHINE; MOSAPRIDE CITRATE; N DES FLUOROBENZYLMOSAPRIDE; PIBOSEROD; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; UNCLASSIFIED DRUG;

ABDOMINAL WALL MUSCULATURE; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; FORCE TRANSDUCER; HOT PLATE TEST; MALE; MUSCLE CONTRACTION; NONHUMAN; PAIN; PAIN THRESHOLD; RAT; RECEPTOR BLOCKING; REFLEX; STOMACH DISTENSION; THERMAL STIMULATION; VISCERAL PAIN; VISCEROMOTOR RESPONSE;

EID: 79956220910     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11012FP     Document Type: Article

References (29)

1. Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130:1466-1479.
2. Tack J, Bisschops R, Samelli G. Pathophysiology and treatment of functional dyspepsia. Gastroenterology. 2004;127:1239-1255. (Pubitemid 39345892)
3. Tack J, Bisschops R, Caenepeel P, Janssens J. Comparison of functional dyspepsia patients with or without meal-related symptoms. Gastroenterology. 2004;126 Suppl 2:A375.
4. Talley NJ, Vakil N. Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol. 2005;100:2324-2337.
5. Mizuta Y, Shikuwa S, Isomoto H, Mishima R, Akazawa Y, Masuda J, et al. Recent insights into digestive motility in functional dyspepsia. J Gastroenterol. 2006;41:1025-1040. (Pubitemid 44896718)
6. Tack J. Prokinetics and fundic relaxants in upper functional GI disorders. Current Opinion Pharmacol. 2008;8:690-696.
7. Curran MP, Robinson DM. Mosapride in gastrointestinal disorders. Drugs. 2008;68:981-991.
8. Yoshida N, Ito T, Karasawa T, Itoh Z. AS-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs. J Pharmacol Exp Ther. 1991;257:781-787.
9. Shimatani H, Kojima Y, Kadowaki M, Nakagawa T, Fujii H, Nakajima Y, et al. A 5-HT4 agonist mosapride enhances rectorectal and rectoanal reflexes in guinea pigs. Am J Physiol Gastrointest Liver Physiol. 2003;285:G389-G395. (Pubitemid 36875211)
10. Inui A, Yoshikawa T, Nagai R, Yoshida N, Ito T. Effects of mosapride citrate, a 5-HT4 receptor agonist, on colonic motility in conscious guinea pigs. Jpn J Pharmacol. 2002;90:313-320. (Pubitemid 36096886)
11. Mine Y, Morikage K, Oku S, Yoshikawa T, Shimizu I, Yoshida N. Effect of mosapride citrate hydrate on the colon cleansing action of polyethylene glycol electrolyte lavage solution (PEG-ELS) in guinea pigs. J Pharmacol Sci. 2009;110:415-423.
12. Yoshida N, Kato S, Ito T. Mosapride citrate. Drug Future. 1993;18:513-515.
13. Hongo M. Initial approach and pharmacotherapy for functional dyspepsia-a large clinical trial in Japan. Gastroenterology. 2006;130 Suppl 2:506.
14. Greenwood-Van Meerveld B, Venkova K, Hicks G, Dennis E, Crowell MD. Activation of peripheral 5-HT receptors attenuates colonic sensitivity to intraluminal distension. Neurogastroenterol Motil. 2006;18:76-86.
15. Bueno L, De Ponti F, Fried M, Kullak-Ublick GA, Kwiatek MA, Pohl D, et al. Serotonergic and non-serotonergic targets in the pharmacotherapy of visceral hypersensitivity. Neurogastroenterol Motil. 2007;19:89-119. (Pubitemid 46058984)
16. Okano S, Ikeura Y, Inatomi N. Effects of tachykinin NK1 receptor antagonists on the viscerosensory response caused by colorectal distension in rabbits. J Pharmacol Exp Ther. 2002;300:925-931. (Pubitemid 34164997)
17. Santos AR, Miguel OG, Yunes RA, Calixto JB. Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dehydrate isolated from Siphocampylus vericillantus: evidence for the mechanism of action. J Pharmacol Exp Ther. 1999;289:417-426. (Pubitemid 29156058)
18. 2 receptor antagonist properties. Arch Int Pharmacodyn Ther. 1989;300:51-67.
19. Iwanaga Y, Miyashita N, Mizutani F, Morikawa K, Kato H, Ito Y, et al. Stimulatory effect of N-(4-(2-(dimethylamino)-ethoxy) benzyl)-3,4- dimethoxybenzamide hydrochloride (HSR-803) on normal and delayed gastrointestinal propulsion. Jpn J Pharmacol. 1991;56:261-269.
20. Gaster LM. SB-207266. Drug Future. 1997;22:1325-1332.
21. Vandenberghe J, Vos R, Persoons P, Demyttenaere K, Janssens J, Tack J. Dyspeptic patients with visceral hypersensitivity: sensitization of specific or multimodal pathways? Gut. 2005;54:914-929.
22. Tack J, Caenepeel P, Fischie B, Piessevaux H, Janssens J. Symptoms associated with hypersensitivity to gastric distension in functional dyspepsia. Gastroenterology. 2001;121:526-535. (Pubitemid 32822566)
23. Ozaki N, Bielefeldt K, Sengupta JN, Gebhart GF. Models of gastric hyperalgesia in the rat. Am J Physiol Gastrointest Liver Physiol. 2002;283:G666-G676. (Pubitemid 34920355)
24. Mearin F, Cucala M, Azpiroz F, Malagelada JR. The origin of symptoms on the brain-gut axis in functional dyspepsia. Gastroenterology. 1991;101:999-1006.
25. Liu L, Winston JH, Shenoy MM, Song GQ, Chen JD, Pasricha PJ. A rat model of chronic gastric sensorimotor dysfunction resulting from transient neonatal gastric irritation. Gastroenterology. 2008;134:2070-2079. (Pubitemid 351783261)
26. Mori T, Kawano K, Shishikura T. 5-HT3-receptor antagonist inhibits visceral pain differently in chemical and mechanical stimuli in rats. J Pharmacol Sci. 2004;94:73-76. (Pubitemid 38197188)
27. Sakashita M, Mizuki Y, Hashizume T, Yamaguchi T, Miyazaki H, Sekine Y. Pharmacokinetics of gastrokinetic agent mosapride citrate after intravenous and oral administration in rats. Arzneimittelforschung. 1993;43:859-863. (Pubitemid 23254934)
28. Sakashita M, Yamaguchi H, Miyazaki Y, Sekine Y, Nomiyama T, Tanaka S, et al. Pharmacokinetics of gastrokinetic agent mosapride citrate after single and multiple oral administrations in healthy subjects. Arzneimittelforschung. 1993;43:867-872. (Pubitemid 23254936)
29. Yoshida N, Omoya H, Kato S, Ito T. Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals. Arzneimittelforschung. 1993;43:1078-1083. (Pubitemid 23311886)