Altered expression of UPIa, UPIb, UPII, and UPIIIa during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats

Virchows Archiv

Volumn 458, Issue 5, 2011, Pages 603-613

  Zupančič, Daša ^a   Ovčak, Zdenka ^b   Vidmar, Gaj ^c   Romih, Rok ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b INSTITUTE OF PATHOLOGY   (Slovenia)

^c UNIVERSITY REHABILITATION INSTITUTE   (Slovenia)

Author keywords

Carcinogenesis; CK 20; Ki 67; Plasma membrane; Uroplakins; Urothelium

Indexed keywords

CYTOKERATIN 20; KI 67 ANTIGEN; N BUTYL N (4 HYDROXYBUTYL)NITROSAMINE; PROTEIN UP 1 A; PROTEIN UP 1 B; PROTEIN UP 2; PROTEIN UP 3 A; UNCLASSIFIED DRUG; UROPLAKIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL MEMBRANE; CELL PROLIFERATION; DYSPLASIA; HYPERPLASIA; KERATINIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RAT; SQUAMOUS CELL CARCINOMA; TRANSITIONAL CELL CARCINOMA;

ANIMALS; BUTYLHYDROXYBUTYLNITROSAMINE; KERATIN-20; MALE; MEMBRANE GLYCOPROTEINS; RATS; RATS, WISTAR; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 79956211238     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-011-1045-6     Document Type: Article

References (50)

1. Negrete HO, Lavelle JP, Berg J, Lewis SA, Zeidel ML (1996) Permeability properties of the intact mammalian bladder epithelium. Am J Physiol 271:F886-F894
2. Staehelin LA, Chlapowski FJ, Bonneville MA (1972) Lumenal plasma membrane of the urinary bladder. I. Three-dimensional reconstruction from freeze-etch images. J Cell Biol 53:73-91
3. Koss LG (1969) The asymmetric unit membranes of the epithelium of the urinary bladder of the rat. An electron microscopic study of a mechanism of epithelial maturation and function. Lab Invest 21:154-168
4. Min G, Zhou G, Schapira M, Sun TT, Kong XP (2003) Structural basis of urothelial permeability barrier function as revealed by Cryo-EM studies of the 16 nm uroplakin particle. J Cell Sci 116:4087-4094 (Pubitemid 37337083)
5. Kachar B, Liang F, Lins U, Ding M, Wu XR, Stoffler D, Aebi U, Sun TT (1999) Three-dimensional analysis of the 16 nm urothelial plaque particle: luminal surface exposure, preferential head-to-head interaction, and hinge formation. J Mol Biol 285:595-608 (Pubitemid 29041795)
6. Romih R, Jezernik K (1996) Reorganization of the urothelial luminal plasma membrane in the cyclophosphamide treated rats. Pflugers Arch Suppl 431:R241-R242 (Pubitemid 26140976)
7. Romih R, Veranic P, Jezernik K (2002) Appraisal of differentiation markers in urothelial cells. Appl Immunohistochem Mol Morphol 10:339-343 (Pubitemid 35453693)
8. Kreplak L, Wang H, Aebi U, Kong XP (2007) Atomic force microscopy of mammalian urothelial surface. J Mol Biol 374:365-373 (Pubitemid 350007654)
9. Hicks RM, Ketterer B (1969) Hexagonal lattice of subunits in the thick luminal membrane of the rat urinary bladder. Nature 224:1304-1305
10. Wu XR, Manabe M, Yu J, Sun TT (1990) Large scale purification and immunolocalisation of bovine uroplakins I, II, and III.Molecular markers of urothelial differentiation. J Biol Chem 265:1775-1784
11. Wu XR, Lin JH, Walz T, Häner M, Yu J, Aebi U, Sun TT (1994) Mammalian uroplakins. A group of highly conserved urothelial differention-related membrane proteins. J Biol Chem 269:13716-13724
12. Yu J, Lin JH, Wu XR, Sun TT (1994) Uroplakins Ia and Ib, two major differention products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. J Cell Biol 125:171-182 (Pubitemid 24100047)
13. Wu XR, Sun TT (1993) Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell glycoprotein. J Cell Sci 106:31-43
14. Lin JH, Wu XR, Kreibich G, Sun TT (1994) Precursor sequence, processing, and urothelium specific expression of a major 15-kDa protein subunit of asymmetric unit membrane. J Biol Chem 269:1775-1784 (Pubitemid 24035374)
15. Wu XR, Medina JJ, Sun TT (1995) Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. J Biol Chem 270:29752-29759 (Pubitemid 26001642)
16. Liang FX, Riedel I, Deng FM, Zhou G, Xu C, Wu XR, Kong XP, Moll R, Sun TT (2001) Organisation of uroplakin subunits: transmembrane topology, pair formation and plaque composition. Biochem J 355:13-18 (Pubitemid 32304230)
17. Tu L, Sun TT, Kreibich G (2002) Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. Mol Biol Cell 13:4221-4230 (Pubitemid 35471180)
18. Hu P, Deng FM, Liang FX, Hu CM, Auerbach A, Shapiro E, Wu XR, Kachar B, Sun TT (2000) Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux. J Cell Biol 151:961-972
19. Kong XT, Deng FM, Hu P, Liang FX, Zhou G, Auerbach AB, Genieser N, Nelson PK, Robbins ES, Shapiro E, Kachar B, Sun TT (2004) Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases. J Cell Biol 167:1195-1204 (Pubitemid 40066633)
20. Sun TT (2006) Altered phenotype of cultured urothelial and other stratified epithelial cells: implications for wound healing. Am J Physiol Ren Physiol 291:F9-F21
21. Kreft ME, Romih R, Kreft M, Jezernik K (2009) Endocytotic activity of bladder superficial urothelial cells is inversely related to their differentiation stage. Differentiation 77:48-59
22. Ogawa K, St John M, Luiza de Oliveira M, Arnold L, Shirai T, Sun TT, Cohen SM (1999) Comparison of uroplakin expression during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats and mice. Toxicol Pathol 27:645-651
23. Huang HY, Shariat SF, Sun TT, Lepor H, Shapiro E, Hsieh JT, Ashfaq R, Lotan Y, Wu XR (2007) Persistent uroplakin expressin in advanced urothelial carcinomas: implications in urothelial tumors progression and clinical outcome. Hum Pathol 38:1703-1713 (Pubitemid 47589094)
24. Ramos-Vara JA, Miller MA, Boucher M, Roudabush A, Johnson GC (2003) Immunohistochemical detection of uroplakin III, cytokeratin 7, and cytokeratin 20 in canine urothelial tumors. Vet Pathol 40:55-62 (Pubitemid 38406114)
25. Ambrosio V, Borzacchiello G, Bruno F, Galati P, Roperto F (2001) Uroplakin expression in the urothelial tumors of cows. Vet Pathol 38:657-660 (Pubitemid 33107548)
26. Jacobs JB, Arai M, Cohen SM, Friedell GH (1977) A long-term study of reversibile and progressive urinary bladder cancer lesions in rats fed N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Cancer Res 37:2817-2821 (Pubitemid 8160430)
27. Fukushima S, Cohen SM (1980) Saccharin-induced hyperplasia of the rat urinary bladder. Cancer Res 40:734-736 (Pubitemid 10174897)
28. Pauli BU, Alroy J, Weinstein RS (1983) The ultrastructure and pathobiology of urinary bladder cancer. In: Bryan GT, Cohen SM (eds) The pathology of bladder cancer, vol 2. CRC Press, Boca Raton, FL, pp 41-140
29. Arai M, Kani T, Sugihara S, Matsumura K, Miyata Y, Shinohara Y, Ito N (1974) Scanning and transmission electron microscopy of changes in the urinary bladder in rats treated with N-butyl-N-(4-hydroxy-butyl)nitrosamine. Gann 65:529-540
30. Jacobs JB, Arai M, Cohen SM, Friedell GH (1976) Early lesions in experimental bladder cancer: scanning electron microscopy of cell surface markers. Cancer Res 36:2512-2517
31. Moll R, Löwe A, Laufer J, Franke WW (1992) Cytokeratin 20 in human carcinomas. Am J Pathol 140:427-447
32. Parker DC, Folpe AL, Bell J, Oliva E, Young RH, Cohen C, Amin MB (2003) Potential utility of uroplakin III, thrombomodulin, high molecular weight cytokeratin, and cytokeratin 20 in noninvasive, invasive, and metastatic urothelial (transitional cell) carcinomas. Am J Surg Pathol 27:1-10 (Pubitemid 36014893)
33. Stavropoulos NE, Ioackim-Velogianni E, Hastazeris K, Kitsiou E, Stefanaki S, Agnantis N (1993) Growth fractions in bladder cancer defined by Ki67: association with cancer grade, category and recurrence rate of superficial lesions. Br J Urol 72:736-739 (Pubitemid 24000132)
34. Margulis V, Lotan Y, Karakiewicz PI, Fradet Y, Ashfaq R, Capitanio U, Montorsi F, Bastian PJ, Nielsen ME, Müller SC, Rigaud J, Heukamp LC, Netto G, Lerner SP, Sagalowsky AI, Shariat SF (2009) Multi-institutional validation of the predictive value if Ki-67 labeling index in patients with urinary bladder cancer. J Natl Cancer Inst 101:114-119
35. Eble JN, Sauter G, Epstein J, Sesterhenn IA (2004) World Health Organization Classification of Tumours: Tumours of the Urinary System and Male Genital Organs. IARC Press, Lyon, France
36. Zupančič D, Jezernik K, Vidmar G (2008) Effect of melatonin on apoptosis, proliferation and differentiation of urothelial cells after cyclophosphamide treatment. J Pineal Res 44:299-306 (Pubitemid 351409348)
37. Ito N (1976) Early changes caused by N-butyl-N-(4-hydroxybutyl) nitrosamine in the bladder epithelium of different animal species. Cancer Res 36:2528-2531
38. Gofrit ON, Birman T, Dinaburg A, Ayesh S, Ohana P, Hochberg A (2006) Chemically induced bladder cancer - a sonographic and morphological description. Urology 68:231-235 (Pubitemid 44037755)
39. Kunze E, Schauer A (1977) Morphology classification, and histogenesis of N-butyl-N-(4-hydroxybutyl)nitrosamine in rats. Z Krebsforsch Klin Onkol Cancer Res 88:273-289 (Pubitemid 8054140)
40. Ariel I, Ayesh S, Gofrit O, Ayesh B, Abdul-Ghani R, Pizov G, Smith Y, Sidi AA, Birman T, Schneider T, de Groot N, Hochberg A (2004) Gene expression in the bladder carcinoma rat model. Mol Carcinog 41:69-76 (Pubitemid 39336756)
41. Hu CC, Liang FX, Zhou G, Tu L, Tang CH, Zhou J, Kreibich G, Sun TT (2005) Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking. Mol Biol Cell 16:3937-3950 (Pubitemid 41262868)
42. Surya B, Yu J, Manabe M, Sun TT (1990) Assessing the differentiation state of cultured bovine urothelial cells: elevated synthesis of stratification-related K5 and K6 keratins and persistent expression of uroplakin I. J Cell Sci 97:419-432 (Pubitemid 20374483)
43. Kreft ME, Sterle M, Veranic P, Jezernik K (2005) Urothelial injuries and the early wound healing response: tight junctions and urothelial cytodifferentiation. Histochem Cell Biol 123:529-539 (Pubitemid 40922236)
44. Kreft ME, Sterle M, Jezernik K (2006) Distribution of junction- and differentiation-related proteins in urothelial cells at the leading edge of primary explant outgrowths. Histochem Cell Biol 125:475-485 (Pubitemid 43673511)
45. Veranic P, Romih R, Jezernik K (2004) What determines differentiation of urothelial umbrella cells? Eur J Cell Biol 83:27-34
46. Yin H, Leong AS (2004) Histologic grading of noninvasive papillary urothelial tumors: validation of the 1998 WHO/ISUP system by immunophenotyping and follow-up. Am J Clin Pathol 121:679-687 (Pubitemid 38534000)
47. Serio G (1994) PCNA/cyclin expression in transitional cell carcinomas of the human bladder: its correlation with Ki-67 and epidermal growth factor receptor immunostainings. Pathologica 86:161-166
48. Mallofré C, Castillo M, Morente V, Solé M (2003) Immunohistochemical expression of CK20, p53, and Ki-67 as objective markers of urothelial dysplasia. Mod Pathol 16:187-191
49. Friedell GH, Nagy GK, Cohen SM (1983) Pathology of human bladder cancer and related lesions. In: Bryan GT, Cohen SM (eds) The pathology of bladder cancer, vol 2. CRC Press, Boca Raton, FL, pp 11-42
50. Celis JE, Rasmussen HH, Vorum H, Madsen P, Honoré B, Wolf H, Orntoft TF (1996) Bladder squamous cell carcinomas express psoriasin and externalize it to the urine. J Urol 155:2105-2112 (Pubitemid 26146716)