Preservation of amputated extremities by extracorporeal blood perfusion; A feasibility study in a porcine model

Journal of Surgical Research

Volumn 171, Issue 1, 2011, Pages 291-299

  Constantinescu, Mihai A ^a   Knall, Erhard ^a   Xu, Xiufang ^a,b,c   Kiermeir, David M ^a   Jenni, Hansjörg ^a   Gygax, Erich ^a   Rieben, Robert ^a,c   Banič, Andrej ^a   Vögelin, Esther ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

animal model; composite tissue allograft; extracorporeal blood perfusion; extremity preservation

Indexed keywords

CARBON DIOXIDE; GLUCOSE; HEMOGLOBIN; INSULIN; LACTIC ACID; OXYGEN; POTASSIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CATHETERIZATION; ARTICLE; AXILLARY ARTERY; AXILLARY VEIN; BIOPSY; BLOOD AUTOTRANSFUSION; COLD ISCHEMIA; CONTROLLED STUDY; CRYOPRESERVATION; EX VIVO STUDY; EXPERIMENTAL MODEL; EXTRACORPOREAL CIRCULATION; FEASIBILITY STUDY; FORELIMB; HEMOGLOBIN DETERMINATION; HISTOLOGY; IMMUNOFLUORESCENCE; LIMB AMPUTATION; LIMB PERFUSION; LIMB PRESERVATION; LIVER METABOLISM; MUSCLE CONTRACTILITY; MUSCLE EXCITATION; NONHUMAN; PH; PRIORITY JOURNAL; STORAGE TEMPERATURE; SWINE;

AMPUTATION; ANIMALS; BLOOD GAS ANALYSIS; BLOOD TRANSFUSION; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EXTRACORPOREAL CIRCULATION; FEASIBILITY STUDIES; FORELIMB; ORGAN PRESERVATION; REGIONAL BLOOD FLOW; REPLANTATION; SWINE; TRANSPLANTATION, HOMOLOGOUS; WATER-ELECTROLYTE BALANCE; WEIGHT GAIN;

EID: 79956209762     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2010.01.040     Document Type: Article

References (57)

1. A. Tuffs Munich surgeons perform world's first transplantation of whole arms Br Med J 337 2008 a1162
2. K.V. Ravindra, J.F. Buell, and C.L. Kaufman Hand transplantation in the United States: Experience with three patients Surgery 144 2008 638 discussion 643
3. R. Margreiter, G. Brandacher, and M. Ninkovic A double-hand transplant can be worth the effort! Transplantation 74 2002 85
4. H.-U. Steinau Limb replantation and postischemia syndrome of acute ischemic-induced myopathy and reperfusion injury 1988 Springer Verlag New York pp 9-33
5. F.W. Blaisdell The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: A review Cardiovasc Surg 10 2002 620
6. I. Muramatsu, N. Takahata, and M. Usui Metabolic and histologic changes in the ischemic muscles of replanted dog legs Clin Orthop Relat Res 196 1985 292
7. P. Petruzzo, M. Lanzetta, and J.M. Dubernard The international registry on hand and composite tissue transplantation Transplantation 86 2008 487
8. S. Hettiaratchy, M.A. Randolph, and W.P. Andrew Lee Long-term consideration of hand transplantation Transplantation 75 2003 1605
9. S.E. Atkins, R.I.S. Winterton, and S.P. Kay Upper limb amputations: Where, when and how to replant Current Orthopedics 22 2008 31
10. K.C. Chung, and A.K. Alderman Replantation of the upper extremity: Indications and outcomes J Am Soc Surg Hand 2 2002 78
11. M.S. Lloyd, T.C. Teo, and M.A. Pickford Preoperative management of the amputated limb Emerg Med J 22 2005 478
12. M.E. Erasmus, M.H. Fernhout, and J.M. Elstrodt Normothermic ex vivo lung perfusion of non-heart-beating donor lungs in pigs: From pretransplant function analysis towards a 6-h machine preservation Transpl Int 19 2006 589
13. M. Adham, S. Peyrol, and M. Chevallier The isolated perfused porcine liver: Assessment of viability during and after six hours of perfusion Transpl Int 10 1997 299
14. A.P. Shah, D.P. Milgrom, and R.S. Mangus Comparison of pulsatile perfusion and cold storage for paired kidney allografts Transplantation 86 2008 1006
15. US National Institutes of and Health Guide for the Care and Use of Laboratory Animals NIH Publication 1996
16. Swiss Academy of Medical Sciences and (SAMS) Ethical Principles and Guidelines for Experiments on Animals 2005 Swiss Academy of Medical, Sciences and (SAMS)
17. J.H. Southard, and F.O. Belzer Organ preservation Annu Rev Med 46 1995 235
18. A.J. McLaren, and P.J. Friend Trends in organ preservation Transpl Int 16 2003 701
19. J.C. Stringham, K.L. Paulsen, and J.H. Southard Prolonging myocardial preservation with a modified University of Wisconsin solution containing 2,3-butanedione monoxime and calcium J Thorac Cardiovasc Surg 107 1994 764
20. P.S. Mankad, N.J. Severs, and D.R. Lachno Superior qualities of University of Wisconsin solution for ex vivo preservation of the pig heart J Thorac Cardiovasc Surg 104 1992 229
21. F. Muhlbacher, F. Langer, and C. Mittermayer Preservation solutions for transplantation Transplant Proc 31 1999 2069
22. M. Karck, A. Vivi, and M. Tassini The effectiveness of University of Wisconsin solution on prolonged myocardial protection as assessed by phosphorus 31-nuclear magnetic resonance spectroscopy and functional recovery J Thorac Cardiovasc Surg 104 1992 1356
23. M. Hicks, A. Hing, and L. Gao Organ preservation Methods Mol Biol 333 2006 331
24. F.M. Hoffman Outcomes and complications after heart transplantation: A review J Cardiovasc Nurs 20 2005 S31
25. A.J. Butler, M.A. Rees, and D.G. Wight Successful extracorporeal porcine liver perfusion for 72 hours Transplantation 73 2002 1212
26. S.D. St Peter, C.J. Imber, and P.J. Friend Liver and kidney preservation by perfusion Lancet 359 2002 604
27. C. Castagnoli, D. Alotto, and I. Cambieri Evaluation of donor skin viability: Fresh and cryopreserved skin using tetrazolioum salt assay Burns 29 2003 759
28. H. Ben-Bassat, M. Chaouat, and N. Segal How long can cryopreserved skin be stored to maintain adequate graft performance? Burns 27 2001 425
29. D. Bravo, T.H. Rigley, and N. Gibran Effect of storage and preservation methods on viability in transplantable human skin allografts Burns 26 2000 367
30. T.L. Delorme, R.S. Shaw, and W.G. Austen A method of studying "normal" function in the amputated human limb using perfusion J Bone Joint Surg Am 46 1964 161
31. T.L. Delorme, R.S. Shaw, and W.G. Austen Musculo-skeletal functions in the amputated perfused human being limb Surg Forum 15 1964 450
32. O'Donovan MJ, Rowlerson A, Taylor, A. Proceedings: The perfused isolated human limb: An assessment of its viability. J Physiol 1976;256:27P.
33. K. Arai, T. Hotokebuchi, and H. Miyahara Successful long-term storage of rat limbs. The use of simple immersion in Euro-Collins solution Int Orthop 17 1993 389
34. L. Gordon, D.G. Levinsohn, and C.D. Borowsky Improved preservation of skeletal muscle in amputated limbs using pulsatile hypothermic perfusion with University of Wisconsin solution. A preliminary study J Bone Joint Surg Am 74 1992 1358
35. M.A. Norden, V.K. Rao, and J.H. Southard Improved preservation of rat hindlimbs with the University of Wisconsin solution and butanedione monoxime Plast Reconstr Surg 100 1997 957
36. H.M. Rosen, M.J. Slivjak, and F.X. McBrearty The role of perfusion washout in limb revascularization procedures Plast Reconstr Surg 80 1987 595
37. A.K. Kour, M.H. Phone, and J. Chia A preliminary report of tissue preservation with University of Wisconsin cold storage solution in major limb replantation Ann Acad Med Singapore 24 1995 37
38. M. Usui, H. Sakata, and S. Ishii Effect of fluorocarbon perfusion upon the preservation of amputated limbs. An experimental study J Bone Joint Surg Br 67 1985 473
39. T.E. Hicks, J.A. Boswick Jr., and C.C. Solomons The effects of perfusion on an amputated extremity J Trauma 20 1980 632
40. T. Tsuchida, T. Kato, and M. Yamaga The effect of perfusion with UW solution on the skeletal muscle and vascular endothelial exocrine function in rat hindlimbs J Surg Res 110 2003 266
41. R.L. Mehl, H.A. Paul, and W.D. Shorey Patency of the microcirculation in the traumatically amputated limb - A comparison of common perfusates J Trauma 4 1964 495
42. J. Domingo-Pech, J.M. Garriga, and N. Toran Preservation of the amputated canine hind limb by extracorporeal perfusion Int Orthop 15 1991 289
43. T. Tsuchida, T. Kato, and M. Yamaga Effect of perfusion during ischemia on skeletal muscle J Surg Res 101 2001 238
44. M.J. Yland, S. Todo, and Y. Zhu An automated and portable low-flow pulsatile perfusion system for organ preservation Transpl Int 9 1996 535
45. Y. Kuroda, Y. Fujino, and A. Morita Successful 96-h preservation of the canine pancreas Transpl Int 5 Suppl 1 1992 S388
46. Y. Yabe, N. Ishiguro, and T. Shimizu Morphologic and metabolic study of the effect of oxygenated perfluorochemical perfusion on amputated rabbit limbs J Reconstr Microsurg 10 1994 185
47. R.J. Edwards, M.J. Im, and J.E. Hoopes Effects of hyperbaric oxygen preservation on rat limb replantation: A preliminary report Ann Plast Surg 27 1991 31
48. W.H. Hassanein, L. Zellos, and T.A. Tyrrell Continuous perfusion of donor hearts in the beating state extends preservation time and improves recovery of function J Thorac Cardiovasc Surg 116 1998 821
49. A.W. Mulivor, and H.H. Lipowsky Inflammation- and ischemia-induced shedding of venular glycocalyx Am J Physiol Heart Circ Physiol 286 2004 H1672
50. R.K. Chan, S.I. Ibrahim, and K. Takahashi The differing roles of the classical and mannose-binding lectin complement pathways in the events following skeletal muscle ischemia-reperfusion J Immunol 177 2006 8080
51. M. Siemionow, and E. Arslan Ischemia/reperfusion injury: A review in relation to free tissue transfers Microsurgery 24 2004 468
52. C. Mold, and C.A. Morris Complement activation by apoptotic endothelial cells following hypoxia/reoxygenation Immunology 102 2001 359
53. R.K. Chan, G. Ding, and N. Verna IgM binding to injured tissue precedes complement activation during skeletal muscle ischemia-reperfusion J Surg Res 122 2004 29
54. M. Zhang, W.G. Austen Jr., and I. Chiu Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury Proc Natl Acad Sci U S A 101 2004 3886
55. H.T. Benzon, J.R. Toleikis, and L.L. Meagher Changes in venous blood lactate, venous blood gases, and somatosensory evoked potentials after tourniquet application Anesthesiology 69 1988 677
56. S. Matsumoto, and Y. Kuroda Perfluorocarbon for organ preservation before transplantation Transplantation 74 2002 1804
57. T. Ahlenstiel, G. Burkhardt, and H. Kohler Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions Transplantation 81 2006 231