Have we overlooked congenital cytomegalovirus infection as a cause of stillbirth?

Journal of Infectious Diseases

Volumn 203, Issue 11, 2011, Pages 1510-1512

  Pereira, Lenore ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOMEGALOVIRUS ANTIBODY; HYPERIMMUNE GLOBULIN;

AMNIOCENTESIS; AUTOPSY; BACTERIAL INFECTION; BIRTH DEFECT; CAUSE OF DEATH; CEREBRAL PALSY; CONGENITAL INFECTION; CYTOMEGALOVIRUS INFECTION; EPIDEMIOLOGICAL DATA; HEARING LOSS; HUMAN; HUMAN CYTOMEGALOVIRUS; INFANT MORTALITY; MENTAL DEFICIENCY; NOTE; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; RACE DIFFERENCE; STILLBIRTH; THROMBOSIS; UNITED STATES; VIRUS INFECTION; VIRUS TRANSMISSION;

CYTOMEGALOVIRUS INFECTIONS; FEMALE; FETAL DEATH; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; STILLBIRTH; UNITED STATES;

EID: 79956200901     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir126     Document Type: Note

References (33)

1. Rawlinson WD, Hall B, Jones CA, et al. Viruses and other infections in stillbirth: What is the evidence and what should we be doing? Pathology 2008; 40:149-60.
2. Gardosi J, Kady SM, McGeown P, Francis A, Tonks A. Classification of stillbirth by relevant condition at death (ReCoDe): Population based cohort study. BMJ 2005; 331:1113-7. (Pubitemid 41634895)
3. Colugnati FA, Staras SA, Dollard SC, Cannon MJ. Incidence of cytomegalovirus infection among the general population and pregnant women in the United States. BMC Infect Dis 2007; 7:71.
4. Pass RF, Little EA, Stagno S, Britt WJ, Alford CA. Young children as a probable source of maternal and congenital cytomegalovirus infection. N Engl J Med 1987; 316:1366-70. (Pubitemid 17079679)
5. Pass RF, Stagno S, Myers GJ, Alford CA. Outcome of symptomatic congenital cytomegalovirus infection: Results of long-term longitudinal follow-up. Pediatrics 1980; 66:758-62. (Pubitemid 11250436)
6. Ross DS, Dollard SC, Victor M, Sumartojo E, Cannon MJ. The epidemiology and prevention of congenital cytomegalovirus infection and disease: Activities of the Centers for Disease Control and Prevention Workgroup. J Womens Health (Larchmt) 2006; 15:224-9. (Pubitemid 43891174)
7. Fowler KB, Stagno S, Pass RF, Britt WJ, Boll TJ, Alford CA. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N Engl J Med 1992; 326:663-7.
8. Pass RF, Fowler KB, Boppana SB, Britt WJ, Stagno S. Congenital cytomegalovirus infection following first trimester maternal infection: Symptoms at birth and outcome. J Clin Virol 2006; 35:216-20. (Pubitemid 43053403)
9. Noyola DE, Demmler GJ, Nelson CT, et al. Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr 2001; 138:325-31. (Pubitemid 32207132)
10. Benirschke K, Mendoza GR, Bazeley PL. Placental and fetal manifestations of cytomegalovirus infection. Virchows Arch B Cell Pathol 1974; 16:121-39.
11. Monif GR, Dische RM. Viral placentitis in congenital cytomegalovirus infection. Am J Clin Pathol 1972; 58:445-9.
12. Garcia AG, Fonseca EF, Marques RL, Lobato YY. Placental morphology in cytomegalovirus infection. Placenta 1989; 10:1-18. (Pubitemid 19113470)
13. Silver RM, Varner MW, Reddy U, et al. Work-up of stillbirth: A review of the evidence. Am J Obstet Gynecol 2007; 196:433-44. (Pubitemid 46627486)
14. Salihu HM, Kinniburgh BA, Aliyu MH, Kirby RS, Alexander GR. Racial disparity in stillbirth among singleton, twin, and triplet gestations in the United States. Obstet Gynecol 2004; 104:734-40. (Pubitemid 40458801)
15. Goldenberg RL, McClure EM, Saleem S, Reddy UM. Infection-related stillbirths. Lancet 2010; 375:1482-90.
16. Syridou G, Spanakis N, Konstantinidou A, et al. Detection of cytomegalovirus, parvovirus B19 and herpes simplex viruses in cases of intrauterine fetal death: association with pathological findings. J Med Virol 2008; 80:1776-82.
17. Pereira L, Maidji E, McDonagh S, Genbacev O, Fisher S. Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity. J Virol 2003; 77:13301-14. (Pubitemid 37494325)
18. McDonagh S, Maidji E, Chang HT, Pereira L. Patterns of human cytomegalovirus infection in term placentas: A preliminary analysis. J Clin Virol 2006; 35:210-5. (Pubitemid 43053402)
19. McDonagh S, Maidji E, Ma W, Chang HT, Fisher S, Pereira L. Viral and bacterial pathogens at the maternal-fetal interface. J Infect Dis 2004; 190:826-34. (Pubitemid 39050014)
20. Nozawa N, Fang-Hoover J, Tabata T, Maidji E, Pereira L. Cytomegalovirus-specific, high-avidity IgG with neutralizing activity in maternal circulation enriched in the fetal bloodstream. J Clin Virol 2009; 46:S58-63.
21. Maidji E, McDonagh S, Genbacev O, Tabata T, Pereira L. Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis. Am J Pathol 2006; 168: 1210-26.
22. Pereira L, Maidji E, McDonagh S, Tabata T. Insights into viral transmission at the uterine- placental interface. Trends Microbiol 2005; 13:164-74. (Pubitemid 40463318)
23. Fisher S, Genbacev O, Maidji E, Pereira L. Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: Implications for transmission and pathogenesis. J Virol 2000; 74:6808-20. (Pubitemid 30470664)
24. Yamamoto-Tabata T, McDonagh S, Chang HT, Fisher S, Pereira L. Human cytomegalovirus interleukin-10 downregulates matrix metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro. J Virol 2004; 78:2831-40. (Pubitemid 38314341)
25. Tabata T, McDonagh S, Kawakatsu H, Pereira L. Cytotrophoblasts infected with a pathogenic human cytomegalovirus strain dysregulate cell-matrix and cell-cell adhesion molecules: A quantitative analysis. Placenta 2007; 28:527-37. (Pubitemid 46593758)
26. Tabata T, Kawakatsu H, Maidji E, et al. Induction of an epithelial integrin avb6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-β1 and increased collagen production. Am J Pathol 2008; 172: 1127-40. (Pubitemid 351520008)
27. Benirschke K, Kaufmann P. Pathology of the human placenta. 4th ed. New York: Springer-Verlag, 2000.
28. Fox H. Abnormalities of the foetal stem arteries in the human placenta. J Obstet Gynaecol Br Commonw 1967; 74:734-8.
29. Redline RW, Pappin A. Fetal thrombotic vasculopathy: The clinical significance of extensive avascular villi. Hum Pathol 1995; 26:80-5.
30. Maidji E, Nigro G, Tabata T, et al. Antibody treatment promotes compensation for human cytomegalovirus-induced pathogenesis and a hypoxia-like condition in placentas with congenital infection. Am J Pathol 2010; 177:1298-310.
31. Revello MG, Gerna G. Pathogenesis and prenatal diagnosis of human cytomegalovirus infection. J Clin Virol 2004; 29: 71-83. (Pubitemid 38121576)
32. Nigro G, Adler SP, La Torre R, Best AM. Congenital Cytomegalovirus Collaborating Group. Passive immunization during pregnancy for congenital cytomegalovirus infection. N Engl J Med 2005; 353: 1350-62. (Pubitemid 41362703)
33. Pass RF, Zhang C, Evans A, et al. Vaccine prevention of maternal cytomegalovirus infection. N Engl J Med 2009; 360:1191-9.