Functional abdominal pain and irritable bowel syndrome in children and adolescents

Therapy

Volumn 8, Issue 3, 2011, Pages 315-331

  Chiou, Eric ^a   Nurko, Samuel ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

biopsychosocial model; cognitive behavioral therapy; dietary interventions; functional abdominal pain; functional gastrointestinal disorders; irritable bowel syndrome; pharmacotherapy; psychosocial interventions; recurrent abdominal pain

Indexed keywords

ALOSETRON; AMITRIPTYLINE; CILANSETRON; CITALOPRAM; CYPROHEPTADINE; DOMPERIDONE; DULOXETINE; HERBACEOUS AGENT; HYOSCYAMINE; LOPERAMIDE; LUBIPROSTONE; MACROGOL 3350; METOCLOPRAMIDE; PEPPERMINT OIL; PLACEBO; PROBIOTIC AGENT; PROKINETIC AGENT; SPASMOLYTIC AGENT; TEGASEROD; VENLAFAXINE;

ABDOMINAL PAIN; ACUPUNCTURE; AGITATION; ALLERGIC REACTION; ALTERNATIVE MEDICINE; BLURRED VISION; BURNING SENSATION; COGNITIVE THERAPY; COMORBIDITY; CONSTIPATION; DIET RESTRICTION; DIETARY FIBER; DROWSINESS; DRUG RESPONSE; EARLY LIFE STRESS; ENVIRONMENTAL FACTOR; ESOPHAGUS PAIN; EXTRAPYRAMIDAL SYMPTOM; FATIGUE; FUNCTIONAL ABDOMINAL PAIN; GASTROINTESTINAL MOTILITY DISORDER; GENETIC PREDISPOSITION; HEARTBURN; HUMAN; HYPNOSIS; INTESTINE FUNCTION; INTESTINE PERFORATION; IRRITABILITY; IRRITABLE COLON; ISCHEMIC COLITIS; PATIENT ASSESSMENT; PHYSICAL EXAMINATION; PSYCHOEDUCATION; REVIEW; SIDE EFFECT; SOCIAL LEARNING; SOCIAL PSYCHOLOGY; TACHYCARDIA; TREATMENT OUTCOME; URINE RETENTION; XEROSTOMIA;

EID: 79956192574     PISSN: 14750708     EISSN: 1744831X     Source Type: Journal    
DOI: 10.2217/thy.11.7     Document Type: Review

References (131)

1. Starfeld B, Hoekelman RA, McCormick M et al.: Who provides health care to children and adolescents in the United States? Pediatrics 74(6), 991-997 (1984). (Pubitemid 15183915)
2. Crushell E, Rowland M, Doherty M et al.: Importance of parental conceptual model of illness in severe recurrent abdominal pain. Pediatrics 112(6 Pt 1), 1368-1372 (2003). (Pubitemid 37523421)
3. Drossman DD, Corazziari E, Delvaux M et al.: Rome III: The Functional Gastrointestinal Disorders (3rd Edition). Degnon Associates, Inc., VA, USA (2006).
4. Apley J, Naish N: Recurrent abdominal pains: a feld survey of 1,000 school children. Arch. Dis. Child 33(168), 165-170 (1958 ).
5. Rasquin A, Di Lorenzo C, Forbes D et al.: Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology 130 (5), 1527-1537 (20 06 ).
6. Di Lorenzo C, Colletti RB, Lehmann HP et al.: Chronic abdominal pain in children: a clinical report of the American Academy of Pediatrics and the North American Society for pediatric Gastroenterology, Hepatology and Nutrition. J. Pediatr. Gastroenterol. Nutr. 40(3), 245-248 (2005). (Pubitemid 40344087)
7. Schurman J V, Hunter HL, Friesen CA: Conceptualization and treatment of chronic abdominal pain in pediatric gastroenterology practice. J. Pediatr. Gastroenterol. Nutr. 50(1), 32-37 (2010 ).
8. Alfven G: One hundred cases of recurrent abdominal pain in children: diagnostic procedures and criteria for a psychosomatic diagnosis. Acta Paediatr. 92(1), 43-49 (2003). (Pubitemid 36255930)
9. Hyams JS, Burke G, Davis PM, Rzepski B, Andrulonis PA: Abdominal pain and irritable bowel syndrome in adolescents: a community-based study. J. Pediatr. 129(2), 220-226 (1996). (Pubitemid 27483793)
10. Youssef NN, Atienza K, Langseder AL, Strauss RS: Chronic abdominal pain and depressive symptoms: analysis of the national longitudinal study of adolescent health. Clin. Gastroenterol. Hepatol. 6(3), 329-332 (2008).
11. Saps M, Seshadri R, Sztainberg M, Schaffer G, Marshall BM, Di Lorenzo C: A prospective school-based study of abdominal pain and other common somatic complaints in children. J. Pediatr. 154(3), 322-326 (2009).
12. Chitkara DK, Rawat DJ, Talley NJ: The epidemiology of childhood recurrent abdominal pain in western countries: a systematic review. Am. J. Gastroenterol. 100(8), 1868-1875 (2005). (Pubitemid 41648444)
13. Caplan A, Walker L, Rasquin A: Validation of the pediatric Rome II criteria for functional gastrointestinal disorders using the questionnaire on pediatric gastrointestinal symptoms. J. Pediatr. Gastroenterol. Nutr. 41(3), 305-316 (2005). (Pubitemid 41285823)
14. Miele E, Simeone D, Marino A et al.: Functional gastrointestinal disorders in children: an Italian prospective survey Pediatrics 114(1), 73-78 (2004). (Pubitemid 38857568)
15. Youssef NN, Murphy TG, Langseder AL, Rosh JR: Quality of life for children with functional abdominal pain: a comparison study of patients' and parents' perceptions. Pediatrics 117(1), 54-59 (2006). (Pubitemid 46050519)
16. Stordal K, Nygaard EA, Bentsen BS: Recurrent abdominal pain: a five-year follow-up study. Acta Paediatr. 94(2), 234-236 (2005). (Pubitemid 40343701)
17. Campo JV, Comer DM, Jansen-Mcwilliams L, Gardner W, Kelleher KJ: Recurrent pain, emotional distress, and health service use in childhood. J. Pediatr. 141(1), 76-83 (2002). (Pubitemid 34774955)
18. HuliszD: The burden of illness of irritable bowel syndrome: current challenges and hope for the future. J. Manag. CarePharm. 10(4), 299-309 (2004).
19. Walker LS, Guite JW, Duke M, Barnard JA, Greene JW: Recurrent abdominal pain: a potential precursor of irritable bowel syndrome in adolescents and young adults. J. Pediatr. 132(6), 1010-1015 (1998). (Pubitemid 28280415)
20. Campo JV, Di Lorenzo C, Chiappetta L et al.: Adult outcomes of pediatric recurrent abdominal pain: do they just grow out of it? Pediatrics 108(1), El (2001).
21. Howell S, Poulton R, Talley NJ: The natural history of childhood abdominal pain and its association with adult irritable bowel syndrome: birth-cohort study Am. J. Gastroenterol. 100(9), 2071-2078 (2005).
22. Hyams JS, Hyman PE: Recurrent abdominal pain and the biopsychosocial model of medical practice. J. Pediatr. 133(4), 473-478 (1998). (Pubitemid 28465371)
23. Drossman DA: The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130(5), 1377-1390 (2006).
24. Locke GR III, Zinsmeister AR, Talley NJ, Fett SL, Melton LJ III: Familial association in adults with functional gastrointestinal disorders. Mayo Clin. Proc. 75(9), 907-912 (2000).
25. Levy RL, Jones KR, Whitehead WE, Feld SI, Talley NJ, Corey LA: Irritable bowel syndrome in twins: heredity and social learning both contribute to etiology Gastroenterology 121(4), 799-804 (2001). (Pubitemid 32959390)
26. Buonavolonta R, Coccorullo P, Turco R, Boccia G, Greco L, Staiano A: Familial aggregation in children affected by functional gastrointestinal disorders. J. Pediatr. Gastroenterol. Nutr. 50(5), 500-505 (2010).
27. Saito YA, Mitra N, Mayer EA: Genetic approaches to functional gastrointestinal disorders. Gastroenterology 138(4), 1276-1285 (2010).
28. Drossman DA, Li Z, Leserman J, Toomey TC, Hu YJ: Health status by gastrointestinal diagnosis and abuse history Gastroenterology 110(4), 999-1007 (1996). (Pubitemid 26113737)
29. Drossman DA, Talley NJ, Leserman J, Olden KW, Barreiro MA: Sexual and physical abuse and gastrointestinal illness. Review and recommendations. Ann. Intern. Med. 123(10), 782-794 (1995).
30. Lowman BC, Drossman DA, Cramer EM, Mckee DC: Recollection of childhood events in adults with irritable bowel syndrome. J Clin. Gastroenterol. 9(3), 324-330 (1987). (Pubitemid 17076984)
31. Barreau F, Ferrier L, Fioramonti J, Bueno L: New insights in the etiology and pathophysiology of irritable bowel syndrome: Contribution of neonatal stress models. Pediatr. Res. 62(3), 240-245 (2007). (Pubitemid 47301468)
32. Anand KJ, Runeson B, Jacobson B: Gastric suction at birth associated with long-term risk for functional intestinal disorders in later life. J Pediatr. 144(4), 449-454 (2004). (Pubitemid 38457346)
33. Ramchandani PG, Stein A, Hotopf M, Wiles NJ: Early parental and child predictors of recurrent abdominal pain at school age: results of a large population-based study J Am. Acad. ChildAdolesc. Psychiatry 45(6), 729-736 (2006). (Pubitemid 43833106)
34. Campo JV, Bridge J, Lucas A et al.: Physical and emotional health of mothers of youth with functional abdominal pain. Arch. Pediatr. Adolesc. Med. 161(2), 131-137 (2007). (Pubitemid 46232461)
35. Walker LS, Garber J, Greene JW: Somatization symptoms in pediatric abdominal pain patients: relation to chronicky of abdominal pain and parent somatization. J. Ahnorm. Child Psychol. 19(4), 379-394(1991).
36. Garber J, Zeman J, Walker LS: Recurrent abdominal pain in children: psychiatric diagnoses and parental psychopathology J Am. Acad. Child Adolesc. Psychiatry 29(4), 648-656 (1990). (Pubitemid 20235354)
37. Van Tilburg MA, Chitkara DK, Palsson OS, Levy RL, Whitehead WE: Parental worries and beliefs about abdominal pain. J Pediatr. Gastroenterol. Nutr. 48(3), 311-317 (2009).
38. Walker LS, Williams SE, Smith CA, Garber J, Van Slyke DA, Lipani TA: Parent attention versus distraction: impact on symptom complaints by children with and without chronic functional abdominal pain. Pain 122(1-2), 43-52 (2006).
39. Bernstein GA, Shaw K: Practice parameters for the assessment and treatment of children and adolescents with anxiety disorders. American Academy of Child and Adolescent Psychiatry. J Am. Acad. Child Adolesc. Psychiatry 36(Suppl. 10), S69-S84 (1997).
40. Campo JV, Bridge J, Ehmann M et al.: Recurrent abdominal pain, anxiety, and depression in primary care. Pediatrics 113(4), 817-824 (2004). (Pubitemid 38437389)
41. Dorn LD, Campo JC, Thato S et al.: Psychological comorbidity and stress reactivity in children and adolescents with recurrent abdominal pain and anxiety disorders. J Am. Acad. Child Adolesc. Psychiatry 42(1), 66-75 (2003). (Pubitemid 39610615)
42. Walker LS, Greene JW: Children with recurrent abdominal pain and their parents: more somatic complaints, anxiety, and depression than other patient families? J Pediatr. Psychol 14(2), 231-243 (1989). (Pubitemid 19165670)
43. Saps M, Pensabene L, Di Martino L et al.: Post-infectious functional gastrointestinal disorders in children. J. Pediatr. 152(6), 812-816, 8l6.el (2008).
44. Thabane M, Simunovic M, Akhtar-Danesh N et al.: An outbreak of acute bacterial gastroenteritis is associated with an increased incidence of irritable bowel syndrome in children. Am. J. Gastroenterol. 105(4), 933-939(2010).
45. Marshall JK, Thabane M, Borgaonkar MR, James C: Postinfectious irritable bowel syndrome after a food-borne outbreak of acute gastroenteritis attributed to a viral pathogen. Clin. Gastroenterol. Hepatol. 5(4), 457-460 (2007). (Pubitemid 46575359)
46. Saps M, Pensabene L, Turco R, Staiano A, Cupuro D, Di Lorenzo C: Rotavirus gastroenteritis: precursor of functional gastrointestinal disorders?J. Pediatr. Gastroenterol. Nutr. 49(5), 580-583 (2009).
47. Shulman RJ, Eakin MN, Czyzewski DI, Jarrett M, Ou CN: Increased gastrointestinal permeability and gut inflammation in children with functional abdominal pain and irritable bowel syndrome. J. Pediatr. 153(5), 646-650 (2008).
48. Singh VV, Toskes PP: Small bowel bacterial overgrowth: Presentation, diagnosis, and treatment. Curr. Treat. Options Gastroenterol. 7(1), 19-28 (2004). (Pubitemid 38923716)
49. Collins BS, Lin HC: Chronic abdominal pain in children is associated with high prevalence of abnormal microbial fermentation. Dig. Dis. Sa. 55(1), 124-130 (2010).
50. Scarpellini E, Giorgio V, Gabrielli M et al.: Prevalence of small intestinal bacterial overgrowth in children with irritable bowel syndrome: a case-control study. J. Pediatr. 155(3), 416-420 (2009).
51. Barbara G, Stanghellini V, De Giorgio R et al.: Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 126(3), 693-702 (2004). (Pubitemid 38298317)
52. Guilarte M, Santos J, De Torres I et al.: Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut 56(2), 203-209 (2007).
53. Klooker TK, Braak B, Koopman KE et al.: The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut 59(9), 1213-1221 (2010).
54. Jones MP, DilleyJB, Drossman D, Crowell MD: Brain-gut connections in functional GI disorders: anatomic and physiologic relationships. Neurogastroenterol. Motil. 18(2), 91-103 (2006).
55. Drossman DA, Camilleri M, Mayer EA, Whitehead WE: AGA technical review on irritable bowel syndrome. Gastroenterology 123(6), 2108-2131 (2002). (Pubitemid 35408332)
56. Di Lorenzo C, Youssef NN, Sigurdsson L, Scharff L, Griffiths J, Wald A: Visceral hyperalgesia in children with functional abdominal pain. J. Pediatr. 139(6), 838-843 (2001). (Pubitemid 34014464)
57. Schurman JV, Friesen CA, Andre L et al.: Diagnostic utility of the water load test in children with chronic abdominal pain. J Pediatr. Gastroenterol. Nutr. 44(1), 51-57 (2007). (Pubitemid 46071792)
58. Van Ginkel R, Voskuijl WP, Benninga MA, Taminiau JA, Boeckxstaens GE: Alterations in rectal sensitivity and motility in childhood irritable bowel syndrome. Gastroenterology 120(1), 31-38 (2001). (Pubitemid 32061866)
59. Anderson JL, Acra S, Bruehl S, Walker LS: Relation between clinical symptoms and experimental visceral hypersensitivity in pediatric patients with functional abdominal pain. J. Pediatr. Gastroenterol. Nutr. 47(3), 309-315 (2008).
60. Faure C, Wieckowska A: Somatic referral of visceral sensations and rectal sensory threshold for pain in children with functional gastrointestinal disorders. J. Pediatr. 150(1), 66-71 (2007). (Pubitemid 44937713)
61. Dorn SD, Palsson OS, Thiwan SI et al.: Increased colonic pain sensitivity in irritable bowel syndrome is the result of an increased tendency to report pain rather than increased neurosensory sensitivity Gut 56(9), 1202-1209 (2007). (Pubitemid 47300419)
62. Kellow JE, Phillips SF, Miller LJ, Zinsmeister AR: Dysmotilky of the small intestine in irritable bowel syndrome. Gut 29(9), 1236-1243 (1988).
63. Simren M, Castedal M, Svedlund J, Abrahamsson H, Bjornsson E: Abnormal propagation pattern of duodenal pressure waves in the irritable bowel syndrome (IBS) [correction of IBD)]. Dig. Dis. Sci. 45(11), 2151-2161 (2000). (Pubitemid 32060385)
64. Schmidt T, Pfeiffer A, Kaess H: Abnormal intestinal motility in irritable bowel syndrome. Gastroenterology 111(5), 1400-1401 (1996). (Pubitemid 26362269)
65. Chey WY, Jin HO, Lee MH, Sun SW, Lee KY Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea. Am. J. Gastroenterol. 96(5), 1499-1506(2001). (Pubitemid 32455081)
66. Sullivan MA, Cohen S, Snape WJ Jr: Colonic myoelectrical activity in irritable-bowel syndrome. Effect of eating and anticholinergics. N Engl. J. Med. 298(16), 878-883 (1978). (Pubitemid 8330172)
67. Rogers J, Henry MM, MisiewiczJJ: Increased segmental activity and intraluminal pressures in the sigmoid colon of patients with the irritable bowel syndrome. Gut 30(5), 634-641 (1989). (Pubitemid 19147076)
68. Keller J, Layer P: Intestinal and anorectal motility and functional disorders. BestPract. Res. Clin. Gastroenterol. 23(3), 407-423 (2009).
69. Sperber AD, Drossman DA: Functional abdominal pain syndrome: constant or frequently recurring abdominal pain. Am. J. Gastroenterol. 105(4), 770-774 (2010).
70. Levy RL, Olden KW, Naliboff BD et al.: Psychosocial aspects of the functional gastrointestinal disorders. Gastroenterology 130(5), 1447-1458 (2006).
71. Di Lorenzo C, Colletti RB, Lehmann HP et al.: Chronic abdominal pain in children: a technical report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr. Gastroenterol. Nutr. 40(3), 249-261 (2005). (Pubitemid 40344088)
72. Yip WC, Ho TF, Yip YY, Chan KY: Value of abdominal sonography in the assessment of children with abdominal pain. J. Clin. Ultrasound26(8), 397-400 (1998). (Pubitemid 28440621)
73. Hyams J, Davis P, Sylvester F, Zeker D, Justinich C, Lerer T: Dyspepsia in children and adolescents: a prospective study J Pediatr. Gastroenterol. Nutr. 30(4), 413-418 (2000). (Pubitemid 30350930)
74. Hyams JS: Irritable bowel syndrome, functional dyspepsia, and functional abdominal pain syndrome. Adolesc. Med. Clin. 15(1), 1-15 (2004). (Pubitemid 38916637)
75. Drossman DA: Functional abdominal pain syndrome. Clin. Gastroenterol. Hepatol. 2(5), 353-365 (2004). (Pubitemid 38561231)
76. Saps M, Youssef N, Miranda A et al.: Multicenter, randomized, placebo-controlled trial of amkriptyline in children with functional gastrointestinal disorders. Gastroenterology 137(4), 1261-1269 (2009).
77. Dearlove J, Dearlove B, Pearl K, Primavesi R: Dietary lactose and the child with abdominal pain. BMJ286, 1936 (1983). (Pubitemid 13106261)
78. Lebenthal E, Rossi T, Nord K, Branski D: Recurrent abdominal pain and lactose absorption in children. Pediatrics 67(6), 828-832 (1981). (Pubitemid 11005265)
79. Gomara R, Halata M, Newman L et al.: Fructose intolerance in children presenting with abdominal pain. J. Pediatr. Gastroenterol. Nutr. 47(3), 303-308 (2008).
80. Ford A, Talley N, Spiegel B, Foxx-Orenstein A, Schiller L, Quigley E: Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. BMJ 13(337), A2313 (2008).
81. Paulo A, Amancio O, De Morals M, Tabacow K: Low-dietary fiber intake as a risk factor for recurrent abdominal pain in children. Bur. J. Clin. Nutr. 60(7), 823-827 (2006). (Pubitemid 43997693)
82. Christensen M: Recurrent abdominal pain and dietary fiber. Am. Dis. Child 140(8), 738-739 (1986).
83. Vandenplas Y, Benninga M: Probiotics and functional gastrointestinal disorders in children. J. Pediatr. Gastroenterol. Nutr. 48(Suppl. 2), S107-S109 (2009).
84. Malinen E, Rinttila T, Kajander K et al.: Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR. Am. J. Gastroenterol. 100(2), 373-382 (2005). (Pubitemid 40314522)
85. Quigley EM: Probiotics in functional gastrointestinal disorders: what are the facts? Curr. Opin. Pharmacol. 8(6), 704-708 (2008).
86. Moayyedi P, Ford A, Talley N et al.: The efficacy of probiotics in the therapy of irritable bowel syndrome: a systematic review. GWDOI:10.1136/gut. 2008.l67270 (2008).
87. Bausserman M, Michail S: The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial. J. Pediatr. 147(2), 197-201 (2005). (Pubitemid 41207833)
88. Gawronska A, Dziechciarz P, Horvath A, Szajewska H: A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children. Aliment. Pharmacol. Ther. 25, 177-184 (2007). (Pubitemid 46046374)
89. Guandalini S, Magazzu G, Chiaro A et al. VSL#3 improves symptoms in children with irritable bowel syndrome: a multicenter, randomized, placebo-controlled, double-blind, crossover studyJ. Pediatr. Gastroenterol. Nutr. 51(1), 24-30 (2010).
90. Lackner JM, Mesmer C, Morley S, Dowzer C, Hamilton S: Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis. J. Consult. Clin. Psychol. 72(6), 1100-1113 (2004). (Pubitemid 39658543)
91. Huertas-Ceballos A, Logan S, Bennett C, Macarthur C: Psychosocial interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Cochrane Database Syst. Rev. (1), CD003014 (2008).
92. Sanders MR, Shepherd RW, Cleghorn G, Woolford H: The treatment of recurrent abdominal pain in children: a controlled comparison of cognitive-behavioral family intervention and standard pediatric care. J Consult. Clin. Psychol. 62(2), 306-314 (1994). (Pubitemid 24129509)
93. Humphreys P, Gevirtz R: Treatment of recurrent abdominal pain: components analysis of four treatment protocols. J Pediatr. Gastroenterol. Nutr. 31(1), 47-51 (2000). (Pubitemid 30456574)
94. Robins PM, Smith SM, Glutting JJ, Bishop CT: A randomized controlled trial of a cognitive-behavioral family intervention for pediatric recurrent abdominal pain. J. Pediatr. Psychol30(5), 397-408 (2005). (Pubitemid 40840478)
95. Duarte MA, Penna FJ, Andrade EM, Cancela CS, Neto JC, Barbosa TF: Treatment of nonorganic recurrent abdominal pain: cognitive-behavioral family intervention. J Pediatr. Gastroenterol. Nutr. 43(1), 59-64 (2006). (Pubitemid 44022387)
96. Levy RL, Langer SL, Walker LS et al.: Cognitive-behavioral therapy for children with functional abdominal pain and their parents decreases pain and other symptoms. Am. J. Gastroenterol. 105(4), 946-956 (2010).
97. Weydert JA, Shapiro DE, Acra SA, Monheim CJ, Chambers AS, Ball TM: Evaluation of guided imagery as treatment for recurrent abdominal pain in children: a randomized controlled trial. BMC Pediatr. 6, 29 (2006).
98. van Tilburg MA, Chitkara DK, Palsson OS et al.: Audio-recorded guided imagery treatment reduces functional abdominal pain in children: a pilot study. Pediatrics 124(5), E890-E897(2009).
99. Vlieger A, Menko-Frankenhuis C, Wolfkamp S, Tromp E, Benninga M: Hypnotherapy for children with functional abdominal pain or irritable bowel syndrome. Gastroenterology 133(5), 1430-1436 (2007). (Pubitemid 350029753)
100. Brent M, Lobato D, Leleiko N: Psychological treatments for pediatric functional gastrointestinal disorders. J. Pediatr. Gastroenterol. Nutr. 48(1), 13-21 (2009).
101. Bursch B: Psychological/cognitive behavioral treatment of childhood functional abdominal pain and irritable bowel syndrome. J. Pediatr. Gastroenterol. Nutr. 47(5), 706-707 (2008).
102. Ditto B,EclacheM, Goldman N: Short-term autonomic and cardiovascular effects of mindfulness body scan meditation. Ann. Behav. Med. 32(3), 227-234 (2006). (Pubitemid 44906937)
103. Di Lorenzo C, Coletti RB, Lehman HP et al.: Chronic abdominal pain in children. Pediatrics 115(3), 812-815 (2005).
104. Lebel AA: Pharmacology. J Pediatr. Gastroenterol. Nutr. 47(5), 703-705 (2008).
105. Ford AC, Talley NJ, Schoenfeld PS, Quigley EM, Moayyedi P: Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis. GW58(3), 367-378 (2009).
106. Bridge JA, Iyengar S, Salary CB et al.: Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials. JAMA 297(15), 1683-1696 (2007).
107. Gutgesell H, Atkins D, BarstR^^//.: Cardiovascular monitoring of children and adolescents receiving psychotropic drugs: a statement for healthcare professionals from the committee on congenital cardiac defects, council on cardiovascular disease in the young, American Heart Association. Circulation 99(7), 979-982 (1999). (Pubitemid 29094318)
108. Bahar RJ, Collins BS, Steinmetz B, Ament ME: Double-blind placebo-controlled trial of amkriptyline for the treatment of irritable bowel syndrome in adolescents. J. Pediatr. 152(5), 685-689 (2008).
109. Campo J, PerelJ, Lucas A et a I.: Chalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: an exploratory study. J Am. Acad. ChildAdolesc. Psychiatry 43(10), 1234-1242 (2004). (Pubitemid 39281663)
110. Ladabaum U, Sharabidze A, Levin TR et al.: Chalopram provides little or no benefit in nondepressed patients with irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 8(1), 42-48 (2010).
111. Kline RM, Kline JJ, Di PalmaJ, Barbero GJ: Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J. Pediatr. 138(1), 125-128 (2001). (Pubitemid 32097156)
112. Sadeghian M, Farahmand F, Fallahi GH, Abbasi A: Cyproheptadine for the treatment of functional abdominal pain in childhood: a double-blinded randomized placebo-controlled trial. Minerva Pediatr. 60(6), 1367-1374(2008).
113. Gershon MD, Tack J: The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132(1), 397-414 (2007). (Pubitemid 46127672)
114. Khoshoo V, Armstead C, Landry L: Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome. Aliment. Pharmacol. Ther. 23(1), 191-196 (2006). (Pubitemid 43381183)
115. Brandt LJ, Chey WD, Foxx-Orenstein AE et al.: An evidence-based position statement on the management of irritable bowel syndrome. Am. Gastroenterol. 104(Suppl. l),Sl-S35 (2009).
116. Karamanolis G, Tack J: Promotilky medications - now and in the future. Dig Dis. 24(3-4), 297-307 (2006).
117. Tack J: Prokinetics and fundic relaxants in upper functional GI disorders. Curr. Opin. Pharmacol. 8(6), 690-696 (2008).
118. Drossman DA, Chey WD, Johanson JF et al.: Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome - results of two randomized, placebo-controlled studies. Aliment. Pharmacol. Ther. 29(3), 329-341 (2009).
119. Cann P, Read N, Holdsworth C, Barends D: Role of loperamide and placebo in management of irritable bowel syndrome (IBS). Dig. Dis. Sa. 29, 239-247 (1984). (Pubitemid 14158881)
120. Pimentel M, Park S, Miocha J, Kane S, Kong Y: The effect of a nonabsorbed oral antibiotic (rifaxamin) on the symptoms of the irritable bowel syndrome: a randomized trial. Ann. Intern. Med. 145(8), 557-563 (2006). (Pubitemid 46780934)
121. Pimentel M, Chatterjee S, Chow E, Park S, Kong Y: Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent of the presence of methane gas: subanalysis of a double-blind randomized controlled study. Dig. Dis. Sci. 51(8), 1297-1301 (2006). (Pubitemid 44315794)
122. Huertas-Ceballos A, Logan S, Bennett C, Macarthur C: Pharmacological interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Cochrane Database Syst. Rev. (1), CD003017 (2008).
123. Vlieger AM, Blink M, Tromp E, Benninga MA: Use of complementary and alternative medicine by pediatric patients with functional and organic gastrointestinal diseases: results from a multicenter survey Pediatrics 122(2), E446-E451 (2008).
124. Day AS: Use of complementary and alternative therapies and probiotic agents by children attending gastroenterology outpatient clinics. J. Paediatr. Child Health 38(4), 343-346 (2002).
125. Heuschkel R, Afzal N, Wuerth A et al.: Complementary medicine use in children and young adults with inflammatory bowel disease. Am. J. Gastroenterol. 97(2), 382-388 (2002). (Pubitemid 34160765)
126. Bensoussan A, TalleyNJ, HingM, Menzies R, Guo A, Ngu M: Treatment of irritable bowel syndrome with chinese herbal medicine: a randomized controlled trial. JAMA 280(18), 1585-1589 (1998). (Pubitemid 28520646)
127. Leung WK,WuJC, Liang SM et al.: Treatment of diarrhea-predominant irritable bowel syndrome with traditional chinese herbal medicine: a randomized placebo-controlled trial. Am. J. Gastroenterol. 101(7), 1574-1580 (2006). (Pubitemid 43980632)
128. SaitoYA, Rey E, Almazar-Elder AE et al.: A randomized, double-blind, placebo-controlled trial of St John's Wort for treating irritable bowel syndrome. Am. J. Gastroenterol. 105(1), 170-177 (2010).
129. Schneider A, Enck P, Streitberger K et al.: Acupuncture treatment in irritable bowel syndrome. GW55(5), 649-654 (2006).
130. LemboAJ, Conboy L, KelleyJM et al.: A treatment trial of acupuncture in IBS patients. Am. J. Gastroenterol. 104(6), 1489-1497(2009).
131. Broide E, PintovS, Portnoy S, BargJ, Klinowski E, Scapa E: Effectiveness of acupuncture for treatment of childhood constipation. Dig. Dis. Sci. 46(6), 1270-1275 (2001). (Pubitemid 32523274)