Why doesn't the brain lose weight, when obese people diet?

Obesity Facts

Volumn 4, Issue 2, 2011, Pages 151-157

  Peters, Achim ^a   Bosy Westphal, Anja ^b   Kubera, Britta ^a   Langemann, Dirk ^c   Goele, Kristin ^b   Later, Wiebke ^b   Heller, Martin ^d   Hubold, Christian ^a   Müller, Manfred James ^b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Allometry; Brain mass; Brain pull; Caloric restriction; Obesity

Indexed keywords

ADULT; AIR DISPLACEMENT PLETHYSMOGRAPHY; ARTICLE; BODY FAT; BRAIN FUNCTION; BRAIN SIZE; BRAIN WEIGHT; CALORIC RESTRICTION; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; DUAL ENERGY X RAY ABSORPTIOMETRY; ENERGY TRANSFER; FEMALE; HUMAN; INSULIN BLOOD LEVEL; KIDNEY MASS; LIVER WEIGHT; METABOLIC RATE; MUSCLE MASS; NEUROPROTECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PLETHYSMOGRAPHY; PRIORITY JOURNAL;

ADIPOSE TISSUE; ADULT; ANIMALS; BRAIN; CALORIC RESTRICTION; CALORIMETRY, INDIRECT; CASE-CONTROL STUDIES; DIET, REDUCING; ENERGY METABOLISM; FEMALE; HUMANS; INSULIN; KIDNEY; LIVER; MUSCLE, SKELETAL; OBESITY; ORGAN SIZE; REFERENCE VALUES; WEIGHT LOSS;

EID: 79956161132     PISSN: 16624025     EISSN: 16624033     Source Type: Journal    
DOI: 10.1159/000327676     Document Type: Article

References (41)

1. Raji CA, Ho AJ, Parikshak NN, Becker JT, Lopez OL, Kuller LH, Hua X, Leow AD, Toga AW, Thompson PM: Brain structure and obesity. Hum Brain Mapp 2010;31:353-364.
2. Debette S, Beiser A, Hoffman U, DeCarli C, O'Donnell CJ, Massaro JM, Au R, Himali JJ, Wolf PA, Fox CS, Seshadri S: Visceral fat is associated with lower brain volume in healthy middle-aged adults. Ann Neurol 2010;68:136-144.
3. Krieger M: Über die Atrophie der menschlichen Organe bei Inanition. [On the atrophy of human organs in inanition]. Z Angew Anat Konstitutionsl 1921;7:87-134.
4. Goodman MN, Lowell B, Belur E, Ruderman NB: Sites of protein conservation and loss during starvation: influence of adiposity. Am J Physiol 1984;246: E383-E390. (Pubitemid 14121199)
5. Muhlau M, Gaser C, Ilg R, Conrad B, Leibl C, Cebulla MH, Backmund H, Gerlinghoff M, Lommer P, Schnebel A, Wohlschlager AM, Zimmer C, Nunnemann S: Gray matter decrease of the anterior cingulate cortex in anorexia nervosa. Am J Psychiatry 2007;164:1850-1857. (Pubitemid 351739238)
6. Gong QY, Roberts N, Garden AS, Whitehouse GH: Fetal and fetal brain volume estimation in the third trimester of human pregnancy using gradient echo MR imaging. Magn Reson Imaging 1998;16:235-240. (Pubitemid 28264520)
7. Kind KL, Roberts CT, Sohlstrom AI, Katsman A, Clifton PM, Robinson JS, Owens JA: Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig. Am J Physiol Regul Integr Comp Physiol 2005;288: R119-R126. (Pubitemid 40023921)
8. Miller SL, Green LR, Peebles DM, Hanson MA, Blanco CE: Effects of chronic hypoxia and protein malnutrition on growth in the developing chick. Am J Obstet Gynecol 2002;186:261-267. (Pubitemid 34165444)
9. Peters A, Langemann D: Build-ups in the supply chain of the brain: on the neuroenergetic cause of obesity and type 2 diabetes mellitus. Front Neuroenergetics 2009;1: doi:10.3389/neuro.14.002.2009.
10. Hitze B, Hubold C, van Dyken R, Schlichting K, Lehnert H, Entringer S, Peters A: How the Selfish Brain Organizes its 'Supply and Demand'. Front Neuroenergetics 2010;2: doi: 10.3389/fnene.2010.00007.
11. Peters A, Hitze B, Langemann D, Bosy-Westphal A, Müller MJ: Brain size, body size, and longevity; Int J Obes 2010;34:1349-1352.
12. Armstrong E: Relative brain size and metabolism in mammals. Science 1983;220:1302-1304. (Pubitemid 13104196)
13. Armstrong E: Brains, bodies and metabolism. Brain Behav Evol 1990;36:166-176. (Pubitemid 20329201)
14. Mink JW, Blumenschine RJ, Adams DB: Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis. Am J Physiol 1981;241: R203-R212.
15. Martin RD: Relative brain size and basal metabolic rate in terrestrial vertebrates. Nature 1981;293:57-60. (Pubitemid 11006041)
16. Glazier DS: Beyond the '3/4-power law': variation in the intra-and interspecific scaling of metabolic rate in animals. Biol Rev Camb Philos Soc 2005;80:611-662. (Pubitemid 43381262)
17. Kolokotrones T, Van S, Deeds EJ, Fontana W: Curvature in metabolic scaling. Nature 2010;464:753-756.
18. Kety SS: The general metabolism of the brain in vivo; in Richter (ed): Metabolism of the Nervous System. London, Pergamon Press, 1957, pp 221-237.
19. Armstrong E: Allometric considerations of the adult mammalian brain, with special emphasis on primates; in Jungers WL (ed): Size and Scaling in Primate Biology. New York, Plenum Press, 1985, pp 115-146.
20. Bosy-Westphal A, Kossel E, Goele K, Later W, Hitze B, Settler U, Heller M, Gluer CC, Heymsfield SB, Müller MJ: Contribution of individual organ mass loss to weight loss-associated decline in resting energy expenditure. Am J Clin Nutr 2009;90:993-1001.
21. Bosy-Westphal A, Danielzik S, Becker C, Geisler C, Onur S, Korth O, Bührens F, Müller MJ: Need for optimal body composition data analysis using air-displacement plethysmography in children and adolescents. J Nutr 2005;135:2257-2262. (Pubitemid 41298397)
22. Snyder WS, Cook MJ, Nasset ES, Karhausen LR, Howells GP, Tipton IH: Report of the Task Group on Reference Man. Oxford, Pergamon Press, 1975.
23. Kim J, Wang Z, Heymsfield SB, Baumgartner RN, Gallagher D: Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method. Am J Clin Nutr 2002;76:378-383. (Pubitemid 34804060)
24. Bader N, Bosy-Westphal A, Dilba B, Müller MJ: Intra-and interindividual variability of resting energy expenditure in healthy male subjects - biological and methodological variability of resting energy expenditure. Br J Nutr 2005;94:843-849. (Pubitemid 41672392)
25. Weir JB: New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 1949;109:1-9.
26. Soreca I, Rosano C, Jennings JR, Sheu LK, Kuller LH, Matthews KA, Aizenstein HJ, Gianaros PJ: Gain in adiposity across 15 years is associated with reduced gray matter volume in healthy women. Psychosom Med 2009;71:485-490.
27. Gustafson D, Lissner L, Bengtsson C, Bjorkelund C, Skoog I: A 24-year follow-up of body mass index and cerebral atrophy. Neurology 2004;63:1876-1881. (Pubitemid 39532384)
28. Jagust W, Harvey D, Mungas D, Haan M: Central obesity and the aging brain. Arch Neurol 2005;62:1545-1548. (Pubitemid 41434559)
29. Haltia LT, Viljanen A, Parkkola R, Kemppainen N, Rinne JO, Nuutila P, Kaasinen V: Brain white matter expansion in human obesity and the recovering effect of dieting. J Clin Endocrinol Metab 2007;92:3278-3284. (Pubitemid 47236403)
30. Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA: Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 2006;49:191-203. (Pubitemid 43089637)
31. Ahren B: Autonomic regulation of islet hormone secretion - implications for health and disease. Diabetologia 2000;43:393-410. (Pubitemid 30237947)
32. Woods SC, Porte D Jr: Neural control of the endocrine pancreas. Physiol Rev 1974;54:596-619.
33. Billaudel B, Sutter BCJ: Immediate in-vivo effect of corticosterone on glucose-induced insulin secretion in the rat. J Endocr 1982;95:315-320. (Pubitemid 13250391)
34. Seaquist ER, Damberg GS, Tkac I, Gruetter R: The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport/metabolism in humans. Diabetes 2001;50:2203-2209. (Pubitemid 33641902)
35. Hasselbalch SG, Knudsen GM, Videbaek C, Pinborg LH, Schmidt JF, Holm S, Paulson OB: No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans. Diabetes 1999;48:1915-1921. (Pubitemid 29458352)
36. Peters A, Langemann D: Stress and eating behavior; f1000 Biol Rep 2010;2:13.
37. Chaput JP, Arguin H, Gagnon C, Tremblay A: Increase in depression symptoms with weight loss: association with glucose homeostasis and thyroid function. Appl Physiol Nutr Metab 2008;33:86-92.
38. Brinkworth GD, Buckley JD, Noakes M, Clifton PM, Wilson CJ: Long-term effects of a very lowcarbohydrate diet and a low-fat diet on mood and cognitive function. Arch Intern Med 2009;169:1873-1880.
39. McClernon FJ, Yancy WS, Jr., Eberstein JA, Atkins RC, Westman EC: The effects of a low-carbohydrate ketogenic diet and a low-fat diet on mood, hunger, and other self-reported symptoms. Obesity (Silver Spring) 2007;15:182-187. (Pubitemid 46219798)
40. Halyburton AK, Brinkworth GD, Wilson CJ, Noakes M, Buckley JD, Keogh JB, Clifton PM: Low-and high-carbohydrate weight-loss diets have similar effects on mood but not cognitive performance. Am J Clin Nutr 2007;86:580-587. (Pubitemid 47435823)
41. Bryan J, Tiggemann M: The effect of weight-loss dieting on cognitive performance and psychological well-being in overweight women. Appetite 2001;36:147-156. (Pubitemid 32574227)