Hepatocyte growth factor has a role in the amelioration of diabetic vascular complications via autophagic clearance of advanced glycation end products: Dispo85E, an HGF inducer, as a potential botanical drug

Metabolism: Clinical and Experimental

Volumn 60, Issue 6, 2011, Pages 888-892

  Peng, Kang Yung ^a   Horng, Lin Yea ^a   Sung, Hui Ching ^a   Huang, Hui Chuan ^a   Wu, Rong Tsun ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CARBON 14; DIOSCOREA ALATA EXTRACT; DISPO85E; MESSENGER RNA; NEUTRALIZING ANTIBODY; PLANT EXTRACT; SCATTER FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BLOOD LEVEL; CLEARANCE; CONTROLLED STUDY; DIABETIC ANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DIOSCOREA ALATA; DRUG MECHANISM; ENDOCYTOSIS; KIDNEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RETINA; RHIZOME; YAM;

ANIMALS; ANTIBODIES, BLOCKING; AUTOPHAGY; DIABETIC ANGIOPATHIES; DIABETIC NEPHROPATHIES; DIABETIC RETINOPATHY; DIOSCOREA; GLYCOSYLATION END PRODUCTS, ADVANCED; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; HYPOGLYCEMIC AGENTS; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; PHYTOTHERAPY; PLANT EXTRACTS; RHIZOME; RNA, MESSENGER;

EID: 79956144763     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2010.08.009     Document Type: Article

References (23)

1. Yan SF, Ramasamy R, Schmidt AM. Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications. Nat Clin Pract Endocrinol Metab 2008;4:285-93. (Pubitemid 351571138)
2. Horiuchi S. The liver is the main site for metabolism of circulating advanced glycation end products. J Hepatol 2002;36:123-5. (Pubitemid 34234026)
3. Smedsrod B, Melkko J, Araki N, et al. Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells. Biochem J 1997;322(Pt 2):567-73. (Pubitemid 27116585)
4. Miyata S, Liu BF, Shoda H, et al. Accumulation of pyrraline-modified albumin in phagocytes due to reduced degradation by lysosomal enzymes. J Biol Chem 1997;272:4037-42. (Pubitemid 27078465)
5. Hansen B, Svistounov D, Olsen R, et al. Advanced glycation end products impair the scavenger function of rat hepatic sinusoidal endothelial cells. Diabetologia 2002;45:1379-88. (Pubitemid 35244890)
6. Funakoshi H, Nakamura T. Hepatocyte growth factor: from diagnosis to clinical applications. Clin Chim Acta 2003;327:1-23. (Pubitemid 35447813)
7. Nakamura T, Nishizawa T, Hagiya M, et al. Molecular cloning and expression of human hepatocyte growth factor. Nature 1989;342:440-3. (Pubitemid 19277521)
8. Zhou YJ, Wang JH, Zhang J. Hepatocyte growth factor protects human endothelial cells against advanced glycation end products-induced apoptosis. Biochem Biophys Res Commun 2006;344:658-66.
9. Mizuno S, Nakamura T. Suppressions of chronic glomerular injuries and TGF-beta 1 production by HGF in attenuation of murine diabetic nephropathy. Am J Physiol Renal Physiol 2004;286:F134-43.
10. Nakamura S, Morishita R, Moriguchi A, et al. Hepatocyte growth factor as a potential index of complication in diabetes mellitus. J Hypertens 1998;16(12 Pt 2):2019-26. (Pubitemid 29002383)
11. Smedsrod B, Pertoft H, Eggertsen G, et al. Functional and morphological characterization of cultures of Kupffer cells and liver endothelial cells prepared by means of density separation in Percoll, and selective substrate adherence. Cell Tissue Res 1985:639-49. (Pubitemid 15024611)
12. Do H, Healey JF, Waller EK, et al. Expression of factor VIII by murine liver sinusoidal endothelial cells. J Biol Chem 1999;274:19587-92.
13. Rodriguez-Enriquez S, Kim I, Currin RT, et al. Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy 2006;2:39-46.
14. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000;290:1717-21. (Pubitemid 32004796)
15. Sarkar S, Ravikumar B, Floto RA, et al. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamineexpanded huntingtin and related proteinopathies. Cell Death Differ 2009;16:46-56.
16. Pickford F, Masliah E, Britschgi M, et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 2008;118:2190-9. (Pubitemid 351872337)
17. Kaniuk NA, Kiraly M, Bates H, et al. Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes 2007;56:930-9. (Pubitemid 46525060)
18. Huang CH, Horng LY, Chen CF, et al. Chinese herb Radix Polygoni Multiflori as a therapeutic drug for liver cirrhosis in mice. J Ethnopharmacol 2007;114:199-206.
19. Yamagishi S, Takeuchi M, Inagaki Y, et al. Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy. Int J Clin Pharmacol Res 2003;23:129-34. (Pubitemid 38821763)
20. Diamanti-Kandarakis E, Piperi C, Kalofoutis A, et al. Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 2005;62:37-43. (Pubitemid 40175281)
21. Dunaif A, Wu X, Lee A, et al. Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS). Am J Physiol Endocrinol Metab 2001;281:E392-9.
22. Liu HY, Han J, Cao SY, et al. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J Biol Chem 2009;284:31484-92.
23. Ishii T, Sato M, Sudo K, et al. Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats. J Biochem 1995;117:1105-12.