The impact of single gene and chromosomal disorders on hospital admissions of children and adolescents: A population-based study

Public Health Genomics

Volumn 14, Issue 3, 2011, Pages 153-161

  Dye, D E ^a,b   Brameld, K J ^a,c   Maxwell, S ^a   Goldblatt, J ^b   Bower, C ^b,d   Leonard, H ^d   Bourke, J ^d   Glasson, E J ^b   O'Leary, P ^a,b,c,e  

^a DEPARTMENT OF HEALTH   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c CURTIN UNIVERSITY   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Adolescents; Children; Genetic disease; Hospital admissions; Hospital costs; Population database

Indexed keywords

ADOLESCENT; ARTICLE; AUSTRALIA; CHILD; CHROMOSOME DISORDER; CYSTIC FIBROSIS; DATA BASE; DISEASE CLASSIFICATION; DOWN SYNDROME; GENETIC DISORDER; HOSPITAL ADMISSION; HOSPITAL COST; HUMAN; MAJOR CLINICAL STUDY; OSTEOGENESIS IMPERFECTA; POPULATION RESEARCH; PRIORITY JOURNAL; THALASSEMIA; VON WILLEBRAND DISEASE;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; GENETIC DISEASES, INBORN; GENETICS, POPULATION; HUMANS; INFANT; INFANT, NEWBORN; PATIENT ADMISSION; WESTERN AUSTRALIA;

EID: 79956118655     PISSN: 16624246     EISSN: 16628063     Source Type: Journal    
DOI: 10.1159/000321767     Document Type: Article

References (29)

1. Bittles AH: Genomics and the changing profile of human disease. Biol Intl 2003; 45: 3-8.
2. Stevenson DA, Carey JC: Contribution of malformations and genetic disorders to mortality in a children's hospital. Am J Med Genet A 2004; 126A:393-397. (Pubitemid 38541807)
3. Carter CO: Changing patterns in the causes of death at the Hospital for Sick Children. Great Ormond St J 1956; 11: 65-68.
4. Hall JG, Powers EK, Mcllvaine RT, Ean VH: The frequency and financial burden of genetic disease in a pediatric hospital. Am J Med Genet 1978; 1: 417-436.
5. Rimoin DL, Connor JM: Nature and frequency of genetic disease; in Rimoin DL, Conner JM, Pyeritz RE, Korf BR (eds): Emery and Rimoin's Principles and Practice of Medical Genetics, ed 5. New York, Churchill Livingston, 2006, pp 55-59.
6. Carnevale A, Hernandez M, Reyes R, Paz F, Sosa C: The frequency and economic burden of genetic disease in a pediatric hospital in Mexico City. Am J Med Genet 1985; 20: 665-675. (Pubitemid 15145428)
7. Day N, Holmes LB: The incidence of genetic disease in a university hospital population. Am J Hum Genet 1973; 25: 237-246.
8. FitzPatrick DR, Skeoch CH, Tolmie JL: Genetic aspects of admissions to a paediatric intensive care unit. Arch Dis Child 1991; 66: 639-641.
9. Kumar P, Radhakrishnan J, Chowdhary MA, Giampietro PF: Prevalence and patterns of presentation of genetic disorders in a pediatric emergency department. Mayo Clin Proc 2001; 76: 777-783. (Pubitemid 32729475)
10. Lialiaris T, Mantadakis E, Kareli D, Mpountoukas P, Tsalkidis A, Chatzimichail A: Frequency of genetic diseases and health coverage of children requiring admission in a general pediatric clinic of northern Greece. Ital J Pediatr 2010; 36: 9.
11. McCandless SE, Brunger JW, Cassidy SB: The burden of genetic disease on inpatient care in a children's hospital. Am J Hum Genet 2004; 74: 121-127. (Pubitemid 38085243)
12. Meguid NA, El Bayoumi SM, Hamdi NF, Amen WM, Sayed M, Mahmoud A: Prevalence of genetic disorders in pediatric emergency deparment Al Galaa teaching hospital. Pak J Biol Sci 2003; 6: 1961-1965.
13. Pinto LIB, Paskulin GA, Graziadio C, Mendez HMM: The frequency of genetic diseases in a high risk ward in a pediatric hospital. Braz J Genet 1996; 19: 145-149. (Pubitemid 26132976)
14. Scriver CR, Neal JL, Saginur R, Clow A: The frequency of genetic disease and congenital malformation among patients in a pediatric hospital. Can Med Assoc J 1973; 108: 1111-1115.
15. Stanley C, Bankier A, Rose C, Robinson K, Halliday J: The genetic basis for admissions to a pediatric hospital (abstract 141). Abstracts for the Genes for Health Meeting, incorporating the Inaugural GRaPH-Int Conference and the 33rd HGSA Annual Scientific Meeting, Fremantle, May 3-6, 2009. Twin Res Hum Genet 2009; 12: 233.
16. Yoon PW, Olney RS, Khoury MJ, Sappenfield WM, Chavez GF, Taylor D: Contribution of birth defects and genetic diseases to pediatric hospitalizations. A populationbased study. Arch Pediatr Adolesc Med 1997; 151: 1096-1103. (Pubitemid 27483918)
17. Casanova JL, Abel L: Human genetics of infectious diseases: a unified theory. EMBO J 2007; 26: 915-922.
18. Davila S, Hibberd ML: Genome-wide association studies are coming for human infectious diseases. Genome Med 2009; 1: 19.
19. Australian Bureau of Statistics: Population by Age and Sex, Regions of Australia, 2008. http://www.abs.gov.au/ausstats/absnsf/ Products/3235.0 ̃ 2008 ̃ Main+Features ̃ Western+Australia?OpenDocument.
20. Holman CD, Bass AJ, Rosman DL, Smith MB, Semmens JB, Glasson EJ, Brook EL, Trutwein B, Rouse IL, Watson CR, de Klerk NH, Stanley FJ: A decade of data linkage in Western Australia: strategic design, applications and benefits of the WA data linkage system. Aust Health Rev 2008; 32: 766-777.
21. The International Statistical Classification of Diseases and Related Health Problems, Australian Modification. 2004. National Centre of Classification of Health, The University of Sydney, Sydney.
22. Australian Government Department of Health and Aging: National hospital cost data collection: WA cost weights. http:// www.health.gov.au/internet/main/ publishing. nsf/Content/health-casemix-data-collections- about-NHCDC.
23. Australian Institute of Health and Welfare: Health expenditure Australia 2006-2007. Health and welfare expenditure series 35. http://www.aihw.gov.au/ publications/index. cfm/title/10659.
24. Baumann U, Stocklossa C, Greiner W, von der Schulenburg JM, von der Hardt H: Cost of care and clinical condition in paediatric cystic fibrosis patients. J Cyst Fibros 2003; 2: 84-90. (Pubitemid 36814095)
25. Nielsen R, Gyrd-Hansen D: Prenatal screening for cystic fibrosis: an economic analysis. Health Econ 2002; 11: 285-299. (Pubitemid 34578415)
26. Manzur AY, Kinali M, Muntoni F: Update on the management of Duchenne muscular dystrophy. Arch Dis Child 2008; 93: 986-990.
27. Leonard S, Bower C, Petterson B, Leonard H: Medical aspects of school-aged children with Down syndrome. Dev Med Child Neurol 1999; 41: 683-688. (Pubitemid 29465558)
28. So SA, Urbano RC, Hodapp RM: Hospitalizations of infants and young children with Down syndrome: evidence from inpatient person-records from a statewide administrative database. J Intellect Disabil Res 2007; 51: 1030-1038. (Pubitemid 350066612)
29. Baird PA, Anderson TW, Newcome HB, Lowry RB: Genetic disorders in children and young adults: a population study. Am J Hum Genet 1988; 42: 677-693.