Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3404-3406

  Glossop, Melanie S ^a   Bazin, Richard J ^a   Dack, Kevin N ^a   Fox, David N A ^a   MacDonald, Graeme A ^a   Mills, Mark ^a   Owen, Dafydd R ^a   Phillips, Chris ^a   Reeves, Keith A ^a   Ringer, Tracy J ^a   Strang, Ross S ^a   Watson, Christine A L ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Angiotensin converting enzyme; Neutral endopeptidase; Oxadiazole; Oxazole; Zinc metalloproteinases

Indexed keywords

5 PHENYL OXAZOLE; ALANINE DERIVATIVE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HETEROARYLALANINE DIACID; METALLOPROTEINASE; NEURAL ENDOPEPTIDASE INHIBITOR; OXAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ZINC; ZINC METALLOPROTEINASE;

ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS;

ACIDS; ALANINE; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEPRILYSIN; OXAZOLES; PROTEASE INHIBITORS;

EID: 79956115534     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.109     Document Type: Article

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