Exploring the mechanism of interaction between 5-(ethoxycarbonyl)-6-methyl-4-(4-methoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one and human serum albumin: Spectroscopic, calorimetric and molecular modeling studies

Journal of Pharmaceutical and Biomedical Analysis

Volumn 55, Issue 5, 2011, Pages 1223-1226

  Wang, Gongke ^a   Li, Xiang ^a   Ding, Xuelian ^a   Wang, Dongchao ^a   Yan, Changling ^a   Lu, Yan ^a  

^a HENAN NORMAL UNIVERSITY   (China)

Author keywords

Binding mechanism; Fluorescence quenching; Human serum albumin; Isothermal titration calorimetry; Molecular modeling; UV absorption spectroscopy

Indexed keywords

5 (ETHOXYCARBONYL) 6 METHYL 4 (4 METHOXYPHENYL) 3,4 DIHYDROPYRIMIDIN 2(1H) ONE; PROTEIN; SERUM ALBUMIN; UNCLASSIFIED DRUG; WARFARIN;

ARTICLE; BINDING SITE; CALORIMETRY; DRUG PROTEIN BINDING; FLUORESCENCE; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR MODEL; PRIORITY JOURNAL; SERUM; SPECTROSCOPY;

BINDING SITES; CALORIMETRY; CHEMISTRY, PHARMACEUTICAL; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PYRIMIDINES; PYRIMIDINONES; SERUM ALBUMIN; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTRUM ANALYSIS;

EID: 79956115069     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.03.006     Document Type: Article

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