Associations between oral and ocular dryness, labial and whole salivary flow rates, systemic diseases and medications in a sample of older people

Community Dentistry and Oral Epidemiology

Volumn 39, Issue 3, 2011, Pages 276-288

  Smidt, D ^a   Torpet, L A ^a   Nauntofte, B ^a   Heegaard, K M ^a   Pedersen, Anne Marie Lynge ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Anatomical therapeutic chemical codes; Diseases; Labial salivary glands; Polypharmacy; Saliva; Xerostomia

Indexed keywords

AGE; AGED; ANALYSIS OF VARIANCE; ARTICLE; CHEMICALLY INDUCED DISORDER; CROSS-SECTIONAL STUDY; DENMARK; DRUG THERAPY; DRY EYE; FEMALE; HEALTH STATUS; HEALTH SURVEY; HUMAN; INTERVIEW; MALE; PREVALENCE; RISK; SALIVATION; SEX DIFFERENCE; STATISTICAL MODEL; STATISTICS; XEROSTOMIA;

AGE FACTORS; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; CROSS-SECTIONAL STUDIES; DENMARK; DRUG THERAPY; DRY EYE SYNDROMES; FEMALE; HEALTH STATUS; HEALTH SURVEYS; HUMANS; INTERVIEWS AS TOPIC; LOGISTIC MODELS; MALE; ODDS RATIO; PREVALENCE; SALIVATION; SEX FACTORS; XEROSTOMIA;

EID: 79956108955     PISSN: 03015661     EISSN: 16000528     Source Type: Journal    
DOI: 10.1111/j.1600-0528.2010.00588.x     Document Type: Article

References (56)

1. Fox PC, van der Ven PF, Sonies BC, Weiffenbach JM, Baum BJ. Xerostomia: evaluation of a symptom with increasing significance. J Am Dent Assoc 1985;110:519-25.
2. Sreebny LM, Valdini A. Xerostomia. Part I: Relationship to other oral symptoms and salivary gland hypofunction. Oral Surg Oral Med Oral Pathol 1988;66:451-8.
3. Närhi TO. Prevalence of subjective feelings of dry mouth in the elderly. J Dent Res 1994;73:20-5.
4. Loesche WJ, Bromberg J, Terpenning MS, Bretz WA, Dominguez BL, Grossman NS et al. Xerostomia, xerogenic medications and food avoidances in selected geriatric groups. J Am Geriatr Soc 1995;43:401-7.
5. Hochberg MC, Tielsch J, Munoz B, Bandeen-Roche K, West SK, Schein OD. Prevalence of symptoms of dry mouth and their relationship to saliva production in community dwelling elderly: The SEE project. Salisbury Eye Evaluation. J Rheumatol 1998;25:486-91. (Pubitemid 28109350)
6. Schein OD, Hochberg MC, Munoz B, Tielsch JM, Bandeen-Roche K, Provost T et al. Dry eye and dry mouth in the elderly: a population-based assessment. Arch Intern Med 1999;159:1359-63. (Pubitemid 29293598)
7. Thomson WM, Chalmers JM, Spencer AJ, Ketabi M. The occurrence of xerostomia and salivary gland hypofunction in a population-based sample of older South Australians. Spec Care Dentist 1999;19:20-3.
8. Sreebny LM. Saliva in health and disease: an appraisal and update. Int Dent J 2000;50:140-61.
9. Österberg T, Landahl S, Hedegard B. Salivary flow, saliva, pH and buffering capacity in 70-year-old men and women. Correlation to dental health, dryness in the mouth, disease and drug treatment. J Oral Rehabil 1984;11:157-70.
10. Närhi TO, Meurman JH, Ainamo A, Nevalainen JM, Schmidt-Kaunisaho KG, Siukosaari P et al. Association between salivary flow rate and the use of systemic medication among 76-, 81-, and 86-year-old inhabitants in Helsinki, Finland. J Dent Res 1992;71:1875-80. (Pubitemid 23036775)
11. Locker D. Subjective reports of oral dryness in an older adult population. Community Dent Oral Epidemiol 1993;21:165-8.
12. Thomson WM. Issues in the epidemiological investigation of dry mouth. Gerodontology 2005;22:65-76.
13. Ikebe K, Matsuda K, Morii K, Wada M, Hazeyama T, Nokubi T et al. Impact of dry mouth and hyposalivation on oral health-related quality of life of elderly Japanese. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:216-22.
14. Sreebny LM, Valdini A, Yu A. Xerostomia. Part II: relationship to nonoral symptoms, drugs, and diseases. Oral Surg Oral Med Oral Pathol 1989;68:419-27. (Pubitemid 19254442)
15. Fox PC, Busch KA, Baum BJ. Subjective reports of xerostomia and objective measures of salivary gland performance. J Am Dent Assoc 1987;115:581-4.
16. Pedersen AM, Bardow A, Jensen SB, Nauntofte B. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis 2002;8:117-29. (Pubitemid 34535060)
17. Vissink A, Spijkervet FK, Van Nieuw AA. Aging and saliva: a review of the literature. Spec Care Dentist 1996;16:95-103. (Pubitemid 126738492)
18. Bretz WA, Loesche WJ, Chen YM, Schork MA, Dominguez BL, Grossman N. Minor salivary gland secretion in the elderly. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89:696-701.
19. Eliasson L, Birkhed D, Carlen A. Feeling of dry mouth in relation to whole and minor gland saliva secretion rate. Arch Oral Biol 2009;54:263-7.
20. Nederfors T, Isaksson R, Mornstad H, Dahlof C. Prevalence of perceived symptoms of dry mouth in an adult Swedish population-relation to age, sex and pharmacotherapy. Community Dent Oral Epidemiol 1997;25:211-6. (Pubitemid 127534004)
21. Thomson WM, Chalmers JM, Spencer AJ, Slade GD. Medication and dry mouth: findings from a cohort study of older people. J Public Health Dent 2000;60:12-20.
22. Kalk WW, Vissink A, Spijkervet FKL, Bootsma H, Nieuw Amerongen AV, Kallenberg CGM. Sialometry and sialochemistry: a non-invasive approach for diagnosing Sjögren's syndrome. Ann Rheum Dis 2002;61:137-44. (Pubitemid 34098429)
23. Pedersen AML, Bardow A, Nauntofte B. Salivary changes and dental caries as potential oral markers of autoimmune salivary gland dysfunction in primary Sjögren's syndrome. BMC Clin Pathol 2005;5:4.
24. Appleyard M. The Copenhagen City Heart Study: Ø sterbroundersøgelsen: a book of tables with the data from the first examination (1976-1978) and a five-year follow-up (1981-1983). Scand J Soc Med 1989;41:1-160.
25. Schnohr P, Jensen JS, Scharling H, Nordestgaard BG. Coronary heart disease risk factors ranked by importance for the individual and community. A 21 year follow-up of 12 000 men and women from The Copenhagen City Heart Study. Eur Heart J. 2002;23:620-6.
26. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American- European Consensus Group. Ann Rheum Dis 2002;61:554-8. (Pubitemid 34539104)
27. WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC Classification and DDD Assignment. Oslo, Norway: WHO Collaborating Centre for Drug Statistics Methodology; 2006.
28. Navazesh M, Mulligan RA, Kipnis V, Denny PA, Denny PC. Comparison of whole saliva flow rates and mucin concentrations in healthy Caucasian young and aged adults. J Dent Res 1992;71:1275-8.
29. Smidt D, Torpet LA, Nauntofte B, Heegaard KM, Pedersen AML. Associations between labial and whole salivary flow rates, systemic diseases and medications in a sample of older people. Community Dent Oral Epidemiol, 2010;38:422-35.
30. Nayak L, Wolff A, Fedele S, Martin-Granizo R, Reichart PA, Russo LL et al. the burden of xerostomia in independent community-dwelling older adults: results from the Saliwell Project. Oral Biosci Med 2004;1:283-9.
31. Thorselius I, Emilson CG, Österberg T. Salivary conditions and drug consumption in older age groups of elderly Swedish individuals. Gerodontics 1988;4:66-70.
32. Koseki M, Maki Y, Matsukubo T, Ohashi Y, Tsubota K. Salivary flow and its relationship to oral signs and symptoms in patients with dry eyes. Oral Dis 2004;10:75-80. (Pubitemid 38352139)
33. Johansson AK, Johansson A, Unell L, Ekback G, Ordell S, Carlsson GE. A 15-yr longitudinal study of xerostomia in a Swedish population of 50-yr-old subjects. Eur J Oral Sci 2009;117:13-9.
34. Dawes C. Circadian rhythms in human salivary flow rate and composition. J Physiol 1972;220:529-45.
35. Nederfors T. Xerostomia and hyposalivation. Adv Dent Res 2000;14:48-56.
36. Sreebny LM, Schwartz SS. A reference guide to drugs and dry mouth, 2nd edition. Gerodontology 1997;14:33-47.
37. Oksenberg A, Froom P, Melamed S. Dry mouth upon awakening in obstructive sleep apnea. J Sleep Res 2006;15:317-20. (Pubitemid 44215549)
38. Schein OD, Munoz B, Tielsch JM, Bandeen-Roche K, West S. Prevalence of dry eye among the elderly. Am J Ophthalmol 1997;124:723-8. (Pubitemid 27523148)
39. Handelman SL, Baric JM, Saunders RH, Espeland MA. Hyposalivatory drug use, whole stimulated salivary flow, and mouth dryness in older, long-term care residents. Spec Care Dentist 1989;9:12-8.
40. Pedersen AM, Reibel J, Nauntofte B. Primary Sjogren's syndrome (pSS): subjective symptoms and salivary findings. J Oral Pathol Med 1999;28:303-11. (Pubitemid 29332332)
41. Bergdahl M. Salivary flow and oral complaints in adult dental patients. Community Dent Oral Epidemiol 2000;28:59-66.
42. Bardow A, Nyvad B, Nauntofte B. Relationships between medication intake, complaints of dry mouth, salivary flow rate and composition, and the rate of tooth demineralization in situ. Arch Oral Biol 2001;46:413-23. (Pubitemid 32289671)
43. Fure S. A ten-year cross-sectional and follow-up study of salivary flow rates and mutans streptococci and lactobacillus counts in elderly Swedish individuals. Oral Health Prev Dent 2003;1:185-94.
44. Österberg T, Birkhed D, Johansson C, Svanborg A. Longitudinal study of stimulated whole saliva in an elderly population. Scand J Dent Res 1992;100:340-5.
45. Wolff M, Kleinberg I. Oral mucosal wetness in hypo- and normosalivators. Arch Oral Biol 1998;43:455-62. (Pubitemid 28350440)
46. Sabato-Mordarski T, Kleinberg I. Measurement and comparison of the residual saliva on various oral mucosal and dentition surfaces in humans. Arch Oral Biol 1996;41:655-65. (Pubitemid 27089663)
47. Matear DW, Locker D, Stephens M, Lawrence HP. Associations between xerostomia and health status indicators in the elderly. J R Soc Health 2006;126:79-85.
48. Bergdahl M, Bergdahl J. Low unstimulated salivary flow and subjective oral dryness: association with medication, anxiety, depression, and stress. J Dent Res 2000;79:1652-8. (Pubitemid 32489429)
49. Asplund R. Nocturia in the elderly in relation to thirst, dry mouth and dry eyes. Can J Urol 2004;11:2322-6.
50. McCarty CA, Bansal AK, Livingston PM, Stanislavsky YL, Taylor HR. The epidemiology of dry eye in Melbourne, Australia. Ophthalmology 1998;105:1114-9.
51. Moss SE, Klein R, Klein BE. Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol 2000;118:1264-8.
52. Pajukoski H, Meurman JH, Halonen P, Sulkava R. Prevalence of subjective dry mouth and burning mouth in hospitalized elderly patients and outpatients in relation to saliva, medication, and systemic diseases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;92:641-9. (Pubitemid 33601779)
53. Bergdahl M, Bergdahl J, Johansson I. Depressive symptoms in individuals with idiopathic subjective dry mouth. J Oral Pathol Med 1997;26:448-50. (Pubitemid 27515379)
54. Atkinson JC, Fox PC. Salivary gland dysfunction. Clin Geriatr Med 1992;8:499-511.
55. Evio S, Tarkkila L, Sorsa T, Furuholm J, Valimaki MJ, Ylikorkala O et al. Effects of alendronate and hormone replacement therapy, alone and in combination, on saliva, periodontal conditions and gingival crevicular fluid matrix metalloproteinase-8 levels in women with osteoporosis. Oral Dis 2006;12:187-93.
56. Thomson WM, Chalmers JM, Spencer AJ, Slade GD, Carter KD. A longitudinal study of medication exposure and xerostomia among older people. Gerodontology 2006;23:205-13.