The N-classification for esophageal cancer staging: Should it be based on number, distance, or extent of the Lymph node metastasis?

World Journal of Surgery

Volumn 35, Issue 6, 2011, Pages 1303-1310

  Xu, Qi Rong ^a   Zhuge, Xue Peng ^a   Zhang, He Lin ^b   Ping, Yu Min ^b   Chen, Long Qi ^a  

^a SICHUAN UNIVERSITY   (China)

^b HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; CANCER STAGING; CLASSIFICATION; COHORT ANALYSIS; COMPARATIVE STUDY; DISEASE FREE SURVIVAL; ESOPHAGUS RESECTION; ESOPHAGUS TUMOR; FEMALE; FOLLOW UP; HUMAN; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LYMPH NODE; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MALE; METASTASIS; METHODOLOGY; MIDDLE AGED; MORTALITY; NEEDLE BIOPSY; NONPARAMETRIC TEST; PATHOLOGY; PATHOPHYSIOLOGY; POSTOPERATIVE COMPLICATION; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; RISK ASSESSMENT; SQUAMOUS CELL CARCINOMA; SURVIVAL;

ADULT; AGED; ANALYSIS OF VARIANCE; BIOPSY, NEEDLE; CARCINOMA, SQUAMOUS CELL; COHORT STUDIES; DISEASE-FREE SURVIVAL; ESOPHAGEAL NEOPLASMS; ESOPHAGECTOMY; FEMALE; FOLLOW-UP STUDIES; HOSPITAL MORTALITY; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; POSTOPERATIVE COMPLICATIONS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; STATISTICS, NONPARAMETRIC; SURVIVAL ANALYSIS;

EID: 79956030462     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-011-1015-9     Document Type: Article

References (28)

1. TW Rice EH Blackstone LA Rybicki, et al. 2003 Refining esophageal cancer staging J Thorac Cardiovasc Surg 25 1103 1113 10.1067/mtc.2003.170 (Pubitemid 36644888)
2. DK Dhar S Hattori Y Tonomoto, et al. 2007 Appraisal of a revised lymph node classification system for esophageal squamous cell cancer Ann Thorac Surg 83 1265 1272 17383324 10.1016/j.athoracsur.2006.12.003 (Pubitemid 46440784)
3. Edge SB, Byrd DR, Compton CC et al (2009) AJCC cancer staging manual, 7th edn. Springer, New York, pp 103-115
4. N Rizk E Venkatraman B Park, et al. 2006 The prognostic importance of the number of involved lymph nodes in esophageal cancer: implications for revisions of the American Joint Committee on Cancer staging system J Thorac Cardiovasc Surg 132 1374 1381 17140960 10.1016/j.jtcvs.2006.07.039 (Pubitemid 44820247)
5. W Hofstetter AM Correa N Bekele, et al. 2000 7) Proposed modification of nodal status in AJCC esophageal cancer staging system Ann Thorac Surg 84 365 375 10.1016/j.athoracsur.2007.01.067
6. NK Altorki XK Zhou B Stiles, et al. 2008 Total number of resected lymph nodes predicts survival in esophageal cancer Ann Surg 248 221 226 18650631 10.1097/SLA.0b013e31817bbe59
7. CP Hsu CY Chen JY Hsia, et al. 2001 Prediction of prognosis by the extent of lymph node involvement in squamous cell carcinoma of the thoracic esophagus Eur J Cardiothorac Surg 19 10 13 11163553 10.1016/S1010-7940(00)00623-0 1:STN:280:DC%2BD3Mzit1aktQ%3D%3D (Pubitemid 32040887)
8. C Kunisaki H Akiyama M Nomura, et al. 2005 Developing an appropriate staging system for esophageal carcinoma J Am Coll Surg 201 884 890 16310691 10.1016/j.jamcollsurg.2005.07.002 (Pubitemid 41689317)
9. JH Fu WZ Huang ZF Huang, et al. 2007 The impact of different N1 status on the prognosis of the thoracic esophageal squamous cell carcinoma Chin J Thorac Cardiovasc Surg 23 28 30
10. D Bogoevski F Onken A Koenig, et al. 2008 Is it time for a new TNM classification in esophageal carcinoma? Ann Surg 247 633 641 18362626 10.1097/SLA.0b013e3181656d07 (Pubitemid 351440614)
11. AJ Greenstein VR Litle SJ Swanson, et al. 2008 Prognostic significance of the number of lymph node metastases in esophageal cancer J Am Coll Surg 206 239 246 18222375 10.1016/j.jamcollsurg.2007.09.003
12. C Mariette G Piessen N Briez, et al. 2008 The number of metastatic lymph nodes and the ratio between metastatic and examined lymph nodes are independent prognostic factors in esophageal cancer regardless of neoadjuvant chemoradiation or lymphadenectomy extent Ann Surg 247 365 371 18216546 10.1097/SLA. 0b013e31815aaadf (Pubitemid 351156783)
13. M Wilson EL Rosato KA Chojnacki, et al. 2008 Prognostic significance of lymph node metastases and ratio in esophageal cancer J Surg Res 146 11 15 18028955 10.1016/j.jss.2007.07.028 (Pubitemid 351442944)
14. AG Casson VW Rusch RJ Ginsberg, et al. 1994 Lymph node mapping of esophageal cancer Ann Thorac Surg 58 1569 1570 7979715 10.1016/0003-4975(94) 91986-0 1:STN:280:DyaK2M%2FntVCqtA%3D%3D (Pubitemid 24347584)
15. SB Hosch NH Stoecklein U Pichlmeier, et al. 2001 Esophageal cancer: the mode of lymphatic tumor cell spread and its prognostic significance J Clin Oncol 19 1970 1975 11283129 1:STN:280:DC%2BD3M3js1yltw%3D%3D (Pubitemid 32702541)
16. HL Zhang LQ Chen RL Liu, et al. 2010 The number of lymph node metastases influences survival and international union against cancer tumor-node-metastasis classification for esophageal squamous cell carcinoma Dis Esophagus 23 53 58 19392846 10.1111/j.1442-2050.2009.00971.x 1:CAS:528:DC%2BC3MXivFaltg%3D%3D
17. H Fujita T Kakegawa H Yamana, et al. 1995 Mortality and morbidity rates, postoperative course, quality of life, and prognosis after extended radical lymphadenectomy for esophageal cancer. Comparison of three-field lymphadenectomy with two-field lymphadenectomy Ann Surg 222 654 662 7487213 10.1097/00000658-199511000-00008 1:STN:280:DyaK28%2Fms12rsA%3D%3D
18. TR DeMeester 1997 Esophageal carcinoma: current controversies Semin Surg Oncol 13 217 233 9229408 10.1002/(SICI)1098-2388(199707/08)13:4<217::AID- SSU2>3.0.CO;2-8 1:STN:280:DyaK2szntlekuw%3D%3D (Pubitemid 27287520)
19. M Tachibana H Yoshimura S Kinugasa, et al. 2001 Clinicopathologic factors correlated with number of metastatic lymph nodes in oesophageal cancer Dig Liver Dis 33 534 538 11816540 10.1016/S1590-8658(01)80103-1 1:STN:280: DC%2BD38%2FovVSrtA%3D%3D (Pubitemid 32994624)
20. Y Xu Z Guo 2000 The number of lymph node with metastases influences survival in patients with cancer of the thoracic esophagus Zhonghua Zhong Liu Za Zhi 22 244 246 11778242 1:STN:280:DC%2BD38%2Flt12huw%3D%3D (Chinese)
21. FS An JQ Huang SH Chen 2003 Analysis of lymph node metastases of 217 cases of thoracic esophageal carcinoma and its impact on prognosis Ai Zheng 22 974 977 12969532 (Chinese)
22. WT Fang WH Chen 2008 Current trends in extended lymph node dissection for thoracic esophageal carcinoma: evidence and experience China Oncol 18 345 349 (Chinese)
23. H Shimada S Okazumi H Matsubara, et al. 2006 Impact of the number and extent of positive lymph nodes in 200 patients with thoracic esophageal squamous cell carcinoma after three-field lymph node dissection World J Surg 30 1441 1449 16871357 10.1007/s00268-005-0462-6 (Pubitemid 44421246)
24. Japanese Society for Esophageal Disease (2008) Japanese classification of esophageal cancer, 10th edn. Kanehara Co. Ltd, Tokyo
25. Y Hu C Hu H Zhang, et al. 2010 How does the number of resected lymph nodes influence TNM staging and prognosis for esophageal carcinoma? Ann Surg Oncol 17 784 790 19953333 10.1245/s10434-009-0818-5
26. P Dutkowski G Hommel T Bottger, et al. 2002 How many lymph nodes are needed for an accurate pN classification in esophageal cancer? Evidence for a new threshold value Hepatogastroenterology 49 176 180 11941947 (Pubitemid 34289511)
27. W Adachi S Koike Y Nimura, et al. 1996 Clinicopathologic characteristics and postoperative outcome in Japanese and Chinese patients with thoracic esophageal cancer World J Surg 20 332 336 8661840 10.1007/s002689900053 1:STN:280:DyaK28zisFKgsQ%3D%3D (Pubitemid 26082686)
28. M Tachibana S Kinugasa H Yoshimura, et al. 2005 Clinical outcomes of extended esophagectomy with three-field lymph node dissection for esophageal squamous cell carcinoma Am J Surg 189 98 109 15701501 10.1016/j.amjsurg.2004.10. 001 (Pubitemid 40215515)