Structural analysis of the recombinant therapeutic product rFVIII and its PEGylated variants using 2-D DIGE

Electrophoresis

Volumn 32, Issue 11, 2011, Pages 1292-1301

  Monetti, Christina ^a   Rottensteiner, Hanspeter ^a   Gritsch, Herbert ^a   Weber, Alfred ^a   Scheiflinger, Friedrich ^a   Turecek, Peter L ^a  

^a BAXTER INNOVATIONS GMBH   (Austria)

Author keywords

B domain deleted FVIII; Desialylation; Hemophilia A; IEF; Quality control

Indexed keywords

CHAINS; MOLECULAR BIOLOGY; QUALITY CONTROL; RECOMBINANT PROTEINS;

B DOMAINS; B-DOMAIN-DELETED FVIII; DESIALYLATION; DIVERSE APPLICATIONS; FACTOR VIII; HEAVY AND LIGHT CHAINS; HEMOPHILIA A; IEF; PEGYLATED; THERAPEUTIC PRODUCTS;

STRUCTURAL ANALYSIS;

HETERODIMER; RECOMBINANT BLOOD CLOTTING FACTOR 8; SIALIC ACID;

ARTICLE; CHEMICAL COMPOSITION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG STRUCTURE; HEAVY CHAIN; ISOELECTRIC FOCUSING; LIGHT CHAIN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DOMAIN; QUALITY CONTROL; SIALYLATION; STRUCTURE ANALYSIS; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; WESTERN BLOTTING;

EID: 79956027639     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.201000627     Document Type: Article

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