The microbiology of secondary and postoperative pancreatic infections: Implications for antimicrobial management

Archives of Surgery

Volumn 146, Issue 5, 2011, Pages 613-619

  Behrman, Stephen W ^a   Bahr, Michael H ^a   Dickson, Paxton V ^a   Zarzaur, Ben L ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CARBAPENEM; CASPOFUNGIN; FLUCONAZOLE; VANCOMYCIN;

ACUTE PANCREATITIS; ADULT; AGED; ALPHA HEMOLYTIC STREPTOCOCCUS; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BACTEROIDES FRAGILIS; CANDIDA ALBICANS; CITROBACTER FREUNDII; CLINICAL ARTICLE; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; ELECTIVE SURGERY; ENTEROBACTER AEROGENES; ENTEROBACTER CLOACAE; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HUMAN; INFECTION RISK; KLEBSIELLA; KLEBSIELLA OZAENAE; LACTOBACILLUS; MEDICAL RECORD REVIEW; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROFLORA; PANCREAS DISEASE; PANCREAS INFECTION; PANCREAS NECROSIS; PANCREAS PSEUDOCYST; PANCREAS RESECTION; POSTOPERATIVE INFECTION; PREOPERATIVE CARE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; SECONDARY INFECTION; SEPSIS; STAPHYLOCOCCUS EPIDERMIDIS; SURGICAL RISK; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ADULT; AGED; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; ANTIFUNGAL AGENTS; BACTERIAL INFECTIONS; CROSS INFECTION; ENTEROCOCCUS FAECALIS; FEMALE; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; MALE; METHICILLIN; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MYCOSES; PANCREATECTOMY; PANCREATIC PSEUDOCYST; PANCREATITIS; PANCREATITIS, ACUTE NECROTIZING; REOPERATION; RETROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; SURGICAL WOUND INFECTION; TENNESSEE; VANCOMYCIN; VANCOMYCIN RESISTANCE;

EID: 79956011093     PISSN: 00040010     EISSN: 15383644     Source Type: Journal    
DOI: 10.1001/archsurg.2011.85     Document Type: Article

References (36)

1. Lumsden A, Bradley EL III. Secondary pancreatic infections. Surg Gynecol Obstet. 1990;170(5):459-467. (Pubitemid 20190890)
2. Behrman SW, Melvin WS, Ellison EC. Pancreatic pseudocysts following acute pancreatitis. Am J Surg. 1996;172(3):228-231. (Pubitemid 26327904)
3. Rau B, Bothe A, Beger HG. Surgical treatment of necrotizing pancreatitis by necrosectomy and closed lavage: changing patient characteristics and outcome in a 19-year, single-center series. Surgery. 2005;138(1):28-39. (Pubitemid 40933769)
4. Mofidi R, Lee AC, Madhavan KK, Garden OJ, Parks RW. Prognostic factors in patients undergoing surgery for severe necrotizing pancreatitis. World J Surg. 2007;31(10):2002-2007. (Pubitemid 47415714)
5. Howard TJ, Patel JB, Zyromski N, et al. Declining morbidity and mortality rates in the surgical management of pancreatic necrosis. J Gastrointest Surg. 2007; 11(1):43-49.
6. Rodriguez JR, Razo AO, Targarona J, et al. Debridement and closed packing for sterile or infected necrotizing pancreatitis: insights into indications and outcomes in 167 patients. Ann Surg. 2008;247(2):294-299.
7. Beger HG, Bittner R, Block S, Büchler M. Bacterial contamination of pancreatic necrosis: a prospective clinical study. Gastroenterology. 1986;91(2):433-438. (Pubitemid 16098373)
8. Howard TJ, Temple MB. Prophylactic antibiotics alter the bacteriology of infected necrosis in severe acute pancreatitis. J Am Coll Surg. 2002;195(6):759-767. (Pubitemid 35470884)
9. De Waele JJ, Vogelaers D, Hoste E, Blot S, Colardyn F. Emergence of antibiotic resistance in infected pancreatic necrosis. Arch Surg. 2004;139(12):1371-1375. (Pubitemid 39602866)
10. Connor S, Alexakis N, Neal T, et al. Fungal infection but not type of bacterial infection is associated with a high mortality in primary and secondary infected pancreatic necrosis. Dig Surg. 2004;21(4):297-304. (Pubitemid 39370395)
11. De Waele JJ, Vogelaers D, Blot S, Colardyn F. Fungal infections in patients with severe acute pancreatitis and the use of prophylactic therapy. Clin Infect Dis. 2003; 37(2):208-213. (Pubitemid 36930351)
12. Miedema BW, Sarr MG, van Heerden JA, Nagorney DM, McIlrath DC, Ilstrup D. Complications following pancreaticoduodenectomy: current management. Arch Surg. 1992;127(8):945-950.
13. Sohn TA, Yeo CJ, Cameron JL, et al. Pancreaticoduodenectomy: role of interventional radiologists in managing patients and complications. J Gastrointest Surg. 2003;7(2):209-219. (Pubitemid 36875790)
14. Büchler MW, Wagner M, Schmied BM, Uhl W, Friess H, Z'graggen K. Changes in morbidity after pancreatic resection: toward the end of completion pancreatectomy. Arch Surg. 2003;138(12):1310-1315. (Pubitemid 37499387)
15. Behrman SW, Zarzaur BL. Intra-abdominal sepsis following pancreatic resection: incidence, risk factors, diagnosis, microbiology, management, and outcome. Am Surg. 2008;74(7):572-578, discussion 578-579.
16. Pederzoli P, Bassi C, Vesentini S, Campedelli A. A randomized multicenter clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem. Surg Gynecol Obstet. 1993;176(5):480-483. (Pubitemid 23138141)
17. Isenmann R, Rünzi M, Kron M, et al; German Antibiotics in Severe Acute Pancreatitis Study Group. Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis: a placebo-controlled study. Gastroenterology. 2004;126(4):997-1004. (Pubitemid 38451171)
18. Dellinger EP, Tellado JM, Soto NE, et al. Early antibiotic treatment for severe acute necrotizing pancreatitis: a randomized, double-blind, placebo-controlled study. Ann Surg. 2007;245(5):674-683. (Pubitemid 46684095)
19. Warshaw AL, Jin GL. Improved survival in 45 patients with pancreatic abscess. Ann Surg. 1985;202(4):408-417. (Pubitemid 16248053)
20. Büchler MW, Gloor B, Müller CA, Friess H, Seiler CA, Uhl W. Acute necrotizing pancreatitits: treatment strategy according to the status of infection. Ann Surg. 2000;232(5):619-626.
21. Gloor B, Müller CA, Worni M, et al. Pancreatic infection in severe pancreatitis: the role of fungus and multiresistant organisms. Arch Surg. 2001;136(5):592-596. (Pubitemid 32417551)
22. Handwerger S, Raucher B, Altarac D, et al. Nosocomial outbreak due to Enterococcus faecium highly resistant to vancomycin, penicillin, and gentamicin. Clin Infect Dis. 1993;16(6):750-755. (Pubitemid 23157976)
23. Karanfil LV, Murphy M, Josephson A, et al. A cluster of vancomycin-resistant Enterococcus faecium in an intensive care unit. Infect Control Hosp Epidemiol. 1992;13(4):195-200.
24. Rubin LG, Tucci V, Cercenado E, Eliopoulos G, Isenberg HD. Vancomycin-resistant Enterococcus faecium in hospitalized children. Infect Control Hosp Epidemiol. 1992;13(12):700-705.
25. Mainous MR, Lipsett PA, O'Brien M; The Johns Hopkins SICU Study Group. Enterococcal bacteremia in the surgical intensive care unit: does vancomycin resistance affect mortality? Arch Surg. 1997;132(1):76-81.
26. Stosor V, Peterson LR, Postelnick M, Noskin GA. Enterococcus faecium bacteremia: does vancomycin resistance make a difference? Arch Intern Med. 1998; 158(5):522-527. (Pubitemid 128681613)
27. Noskin GA. Vancomycin-resistant enterococci: clinical, microbiologic, and epidemiologic features. J Lab Clin Med. 1997;130(1):14-20. (Pubitemid 27340784)
28. Pelz RK, Hendrix CW, Swoboda SM, et al. Double-blind placebo-controlled trial of fluconazole to prevent candidal infections in critically ill surgical patients. Ann Surg. 2001;233(4):542-548. (Pubitemid 32234953)
29. Calandra T, Bille J, Schneider R, Mosimann F, Francioli P. Clinical significance of Candida isolated from peritoneum in surgical patients. Lancet. 1989;2(8677): 1437-1440. (Pubitemid 20012067)
30. Vege SS, Gardner TB, Chari ST, et al. Outcomes of intra-abdominal fungal vs. bacterial infections in severe acute pancreatitis. Am J Gastroenterol. 2009; 104(8):2065-2070.
31. He YM, Lv XS, Ai ZL, et al. Prevention and therapy of fungal infection in severe acute pancreatitis: a prospective clinical study. World J Gastroenterol. 2003; 9(11):2619-2621.
32. Grewe M, Tsiotos GG, Luque de-Leon E, Sarr MG. Fungal infection in acute necrotizing pancreatitis. J Am Coll Surg. 1999;188(4):408-414.
33. Olivero JJ, Lozano J, Suki WN. Acute pancreatitis, pancreatic pseudocyst, and Candida peritonitis in recipient of a kidney transplant. South Med J. 1976;69 (12):1619-1620. (Pubitemid 8055336)
34. Haney JC, Pappas TN. Necrotizing pancreatitis: diagnosis and management. Surg Clin North Am. 2007;87(6):1431-1446, ix.
35. Hartwig W, Werner J, Müller CA, Uhl W, Büchler MW. Surgical management of severe pancreatitis including sterile necrosis. J Hepatobiliary Pancreat Surg. 2002; 9(4):429-435. (Pubitemid 36305078)
36. Rattner DW, Legermate DA, Lee MJ, Mueller PR, Warshaw AL. Early surgical débridement of symptomatic pancreatic necrosis is beneficial irrespective of infection. Am J Surg. 1992;163(1):105-110.