Cannabis use at a young age is associated with psychotic experiences

Psychological Medicine

Volumn 41, Issue 6, 2011, Pages 1301-1310

  Schubart, C D ^a,c   Van Gastel, W A ^a   Breetvelt, E J ^a   Beetz, S L ^a   Ophoff, R A ^a,b,c   Sommer, I E C ^a   Kahn, R S ^a   Boks, M P M ^a,c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Cannabis; psychosis; psychotic symptoms; THC

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CANNABIS ADDICTION; CANNABIS SMOKING; CHILD; FEMALE; HUMAN; MALE; NETHERLANDS; ONSET AGE; PSYCHOLOGICAL ASPECT; PSYCHOSIS; QUESTIONNAIRE; STATISTICS;

ADOLESCENT; ADULT; AGE OF ONSET; CHILD; FEMALE; HUMANS; MALE; MARIJUANA ABUSE; MARIJUANA SMOKING; NETHERLANDS; PSYCHOSES, SUBSTANCE-INDUCED; QUESTIONNAIRES; STATISTICS AS TOPIC; YOUNG ADULT;

EID: 79956011074     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S003329171000187X     Document Type: Article

References (61)

1. Adlaf EM, Begin P, Sawka E (2005). Canadian Addiction Survey (CAS): A National Survey of Canadians' Use of Alcohol and Other Drugs: Prevalence of Use and Related Harms: Detailed Report. Canadian Centre on Substance Abuse : Ottawa, Canada.
2. Arseneault L, Cannon M, Poulton R, Murray R, Caspi A, Moffitt TE (2002). Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study. British Medical Journal 325, 1212-1213. (Pubitemid 35398785)
3. Balter KA, Balter O, Fondell E, Lagerros YT (2005). Web-based and mailed questionnaires: a comparison of response rates and compliance. Epidemiology 16, 577-579. (Pubitemid 40847846)
4. Buchanan T, Smith JL (1999). Using the Internet for psychological research: personality testing on the World Wide Web. British Journal of Psychology 90, 125-144.
5. CBS Statistics Netherlands (2008). Bijna evenveel hoogopgeleide als laagopgeleide Nederlanders (Almost as many high-skilled and unskilled Dutch). CBS Webmagazine publication no. 2436. Centraal Bureau voor de Statistiek (CBS; Dutch Central Bureau of Statistics): The Hague, The Netherlands.
6. CBS Statistics Netherlands (2009). Press Release, Oktober 28th 2009: Mediaproducten steeds meer via Internet (Media products are increasingly using the Internet). Publication no. PB08-071. Centraal Bureau voor de Statistiek (CBS; Dutch Central Bureau of Statistics): The Hague, The Netherlands.
7. Cha YM, White AM, Kuhn CM, Wilson WA, Swartzwelder HS (2006). Differential effects of delta9-THC on learning in adolescent and adult rats. Pharmacology, Biochemistry and Behavior 83, 448-455. (Pubitemid 43736959)
8. Chapman LJ, Chapman JP, Kwapil TR, Eckblad M, Zinser MC (1994). Putatively psychosis-prone subjects 10 years later. Journal of Abnormal Psychology 103, 171-183. (Pubitemid 24152791)
9. Chevaleyre V, Takahashi KA, Castillo PE (2006). Endocannabinoid-mediated synaptic plasticity in the CNS. Annual Review of Neuroscience 29, 37-76. (Pubitemid 44476839)
10. Coles ME, Cook LM, Blake TR (2007). Assessing obsessive compulsive symptoms and cognitions on the Internet : evidence for the comparability of paper and Internet administration. Behaviour Research and Therapy 45, 2232-2240. (Pubitemid 47210946)
11. Cuijpers P, Boluijt P, van Straten A (2008). Screening of depression in adolescents through the Internet: sensitivity and specificity of two screening questionnaires. European Child and Adolescent Psychiatry 17, 32-38. (Pubitemid 351202149)
12. Development Core Team (2005). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna.
13. Donker T, van Straten A, Marks I, Cuijpers P (2009). Brief self-rated screening for depression on the Internet. Journal of Affective Disorders 122, 253-259.
14. Ekman A, Dickman PW, Klint A, Weiderpass E, Litton JE (2006). Feasibility of using web-based questionnaires in large population-based epidemiological studies. European Journal of Epidemiology 21, 103-111. (Pubitemid 43341198)
15. European Monitoring Centre for Drugs and Drugs Addiction (EMCDDA) (2008). Annual Report: The State of the Drugs Problem in Europe. EMCDDA: Lisbon, Portugal.
16. Fergusson DM, Horwood LJ, Swain-Campbell NR (2003). Cannabis dependence and psychotic symptoms in young people. Psychological Medicine 33, 15-21. (Pubitemid 36113396)
17. Fernandez-Ruiz J, Berrendero F, Hernandez ML, Ramos JA (2000). The endogenous cannabinoid system and brain development. Trends in Neurosciences 23, 14-20. (Pubitemid 30100308)
18. Garcia-Gil L, de Miguel R, Munoz RM, Cebeira M, Villanua MA, Ramos JA, Fernandez-Ruiz JJ (1997). Perinatal delta(9)-tetrahydrocannabinol exposure alters the responsiveness of hypothalamic dopaminergic neurons to dopamine-acting drugs in adult rats. Neurotoxicology and Teratology 19, 477-487. (Pubitemid 27489351)
19. Garcia-Gil L, de Miguel R, Romero J, Perez A, Ramos JA, Fernandez-Ruiz JJ (1999). Perinatal delta9-tetrahydrocannabinol exposure augmented the magnitude of motor inhibition caused by GABA(B), but not GABA(A), receptor agonists in adult rats. Neurotoxicology and Teratology 21, 277-283. (Pubitemid 29301703)
20. Gosling SD, Vazire S, Srivastava S, John OP (2004). Should we trust web-based studies? A comparative analysis of six preconceptions about Internet questionnaires. American Psychologist 59, 93-104. (Pubitemid 38318025)
21. Graham AL, Papandonatos GD (2008). Reliability of Internet-versus telephone-administered questionnaires in a diverse sample of smokers. Journal of Medical Internet Research 10, e8.
22. Graham AL, Papandonatos GD, Bock BC, Cobb NK, Baskin-Sommers A, Niaura R, Abrams DB (2006). Internet-vs. telephone-administered questionnaires in a randomized trial of smoking cessation. Nicotine and Tobacco Research 8 (Suppl. 1), S49-S57.
23. Hanssen M, Bak M, Bijl R, Vollebergh W, van Os J (2005). The incidence and outcome of subclinical psychotic experiences in the general population. British Journal of Clinical Psychology 44, 181-191. (Pubitemid 40873432)
24. Hanssen M, Peeters F, Krabbendam L, Radstake S, Verdoux H, van Os J (2003). How psychotic are individuals with non-psychotic disorders? Social Psychiatry and Psychiatric Epidemiology 38, 149-154. (Pubitemid 37160778)
25. Hernandez M, Berrendero F, Suarez I, Garcia-Gil L, Cebeira M, Mackie K, Ramos JA, Fernandez-Ruiz J (2000). Cannabinoid CB(1) receptors colocalize with tyrosine hydroxylase in cultured fetal mesencephalic neurons and their activation increases the levels of this enzyme. Brain Research 857, 56-65. (Pubitemid 30107790)
26. Hides L, Lubman DI, Buckby J, Yuen HP, Cosgrave E, Baker K, Yung AR (2009). The association between early cannabis use and psychotic-like experiences in a community adolescent sample. Schizophrenia Research 112, 130-135.
27. Houston TK, Cooper LA, Vu HT, Kahn J, Toser J, Ford DE (2001). Screening the public for depression through the Internet. Psychiatric Services 52, 362-367. (Pubitemid 32259672)
28. Johnston LD, O'Malley PM, Bachman JG, Schulenberg JE (2009). Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 2008. NIH publication no. 09-7401. National Institute on Drug Abuse : Bethesda, MD.
29. Joinson A (1999). Social desirability, anonymity, and Internet-based questionnaires. Behavior Research Methods, Instruments, and Computers 31, 433-438.
30. Khazaal Y, Chatton A, Cochand S, Zullino D (2008). Quality of web-based information on cannabis addiction. Journal of Drug Education 38, 97-107.
31. Konings M, Bak M, Hanssen M, van Os J, Krabbendam L (2006). Validity and reliability of the CAPE: a self-report instrument for the measurement of psychotic experiences in the general population. Acta Psychiatrica Scandinavica 114, 55-61. (Pubitemid 43885486)
32. Konings M, Henquet C, Maharajh HD, Hutchinson G, van Os J (2008). Early exposure to cannabis and risk for psychosis in young adolescents in Trinidad. Acta Psychiatrica Scandinavica 118, 209-213.
33. Lewis DA (1997). Development of the prefrontal cortex during adolescence: insights into vulnerable neural circuits in schizophrenia. Neuropsychopharmacology 16, 385-398. (Pubitemid 27244444)
34. Lin CC, Bai YM, Liu CY, Hsiao MC, Chen JY, Tsai SJ, Ouyang WC, Wu CH, Li YC (2007). Web-based tools can be used reliably to detect patients with major depressive disorder and subsyndromal depressive symptoms. BMC Psychiatry 7, 12.
35. McGrath J, Welham J, Scott J, Varghese D, Degenhardt L, Hayatbakhsh MR, Alati R, Williams GM, Bor W, Najman JM (2010). Association between cannabis use and psychosis-related outcomes using sibling pair analysis in a cohort of young adults. Archives of General Psychiatry 67, 440-447.
36. Mechoulam R, Gaoni Y (1965). A total synthesis of DL-delta-1- tetrahydrocannabinol, the active constituent of hashish. Journal of the American Chemical Society 87, 3273-3275.
37. Meyerson P, Tryon WW (2003). Validating Internet research: a test of the psychometric equivalence of Internet and in-person samples. Behavior Research Methods, Instruments, and Computers 35, 614-620. (Pubitemid 38203113)
38. Miettunen J, Tormanen S, Murray GK, Jones PB, Maki P, Ebeling H, Moilanen I, Taanila A, Heinimaa M, Joukamaa M, Veijola J (2008). Association of cannabis use with prodromal symptoms of psychosis in adolescence. British Journal of Psychiatry 192, 470-471. (Pubitemid 351809902)
39. Molina-Holgado F, Alvarez FJ, Gonzalez I, Antonio MT, Leret ML (1997). Maternal exposure to delta 9-tetrahydrocannabinol (delta 9-THC) alters indolamine levels and turnover in adult male and female rat brain regions. Brain Research Bulletin 43, 173-178. (Pubitemid 27284060)
40. Moore TH, Zammit S, Lingford-Hughes A, Barnes TR, Jones PB, Burke M, Lewis G (2007). Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet 370, 319-328. (Pubitemid 47094993)
41. Niesink R, Rigter S, Hoek J, den Boer N (2009). THC-concentraties in wiet, nederwiet en hasj in Nederlands coffeeshops (2008-2009). Trimbos Institute, The Netherlands Institute of Mental Health and Addiction: Utrecht, The Netherlands.
42. O'Shea M, Singh ME, McGregor IS, Mallet PE (2004). Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats. Journal of Psychopharmacology 18, 502-508. (Pubitemid 39665118)
43. Patton GC, Coffey C, Carlin JB, Degenhardt L, Lynskey M, Hall W (2002). Cannabis use and mental health in young people: cohort study. British Medical Journal 325, 1195-1198. (Pubitemid 35398781)
44. Poulton R, Caspi A, Moffitt TE, Cannon M, Murray R, Harrington H (2000). Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Archives of General Psychiatry 57, 1053-1058.
45. Quinn HR, Matsumoto I, Callaghan PD, Long LE, Arnold JC, Gunasekaran N, Thompson MR, Dawson B, Mallet PE, Kashem MA, Matsuda-Matsumoto H, Iwazaki T, McGregor IS (2008). Adolescent rats find repeated delta(9)-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure. Neuropsychopharmacology 33, 1113-1126. (Pubitemid 351367534)
46. Robins LN, Wing J, Wittchen HU, Helzer JE, Babor TF, Burke J, Farmer A, Jablenski A, Pickens R, Regier DA (1988). The Composite International Diagnostic Interview. An epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Archives of General Psychiatry 45, 1069-1077. (Pubitemid 19005460)
47. Rubin DB (1987). Multiple Imputation for Nonresponse in Surveys (1st edn). John Wiley & Sons: New York.
48. Schneider M, Koch M (2003). Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats. Neuropsychopharmacology 28, 1760-1769. (Pubitemid 41070841)
49. Spek V, Nyklicek I, Cuijpers P, Pop V (2008). Internet administration of the Edinburgh Depression Scale. Journal of Affective Disorders 106, 301-305.
50. Stefanis NC, Delespaul P, Henquet C, Bakoula C, Stefanis CN, van Os J (2004). Early adolescent cannabis exposure and positive and negative dimensions of psychosis. Addiction 99, 1333-1341. (Pubitemid 39330938)
51. Stefanis NC, Hanssen M, Smirnis NK, Avramopoulos DA, Evdokimidis IK, Stefanis CN, Verdoux H, van Os J (2002). Evidence that three dimensions of psychosis have a distribution in the general population. Psychological Medicine 32, 347-358. (Pubitemid 34162592)
52. Suarez I, Bodega G, Fernandez-Ruiz J, Ramos JA, Rubio M, Fernandez B (2004). Down-regulation of the AMPA glutamate receptor subunits GluR1 and GluR2/3 in the rat cerebellum following pre-and perinatal delta9- tetrahydrocannabinol exposure. Cerebellum 3, 66-74. (Pubitemid 38797065)
53. Substance Abuse and Mental Health Services Administration (2008). Results from the 2007 National Survey on Drug Use and Health: National Findings. Office of Applied Studies, NSDUH Series H-34. DHHS publication no. SMA 08-4343. SAMHSA, Office of Applied Studies: Rockville, MD.
54. SAMHSA, Office of Applied Studies: Rockville, MD. Trezza V, Cuomo V, Vanderschuren LJ (2008). Cannabis and the developing brain: insights from behavior. European Journal of Pharmacology 585, 441-452.
55. United Nations Office on Drugs and Crime (2009). World Drug Report 2009. UNODC: Vienna, Austria.
56. Vallejo MA, Jordan CM, Diaz MI, Comeche MI, Ortega J (2007). Psychological assessment via the Internet: a reliability and validity study of online (vs paper-and-pencil) versions of the General Health Questionnaire-28 (GHQ-28) and the Symptoms Check-List-90-Revised (SCL-90-R). Journal of Medical Internet Research 9, e2. (Pubitemid 47450402)
57. Van Laar MW, Cruts AAN, Verdurmen JEE, van Ooyen-Houben MMJ, Meijer RF (2008). National Drugs Monitor 2007. Trimbos Institute, The Netherlands Institute of Mental Health and Addiction: Utrecht, The Netherlands.
58. Van Os J, Kapur S (2009). Schizophrenia. Lancet 374, 635-645.
59. Verdoux H, Sorbara F, Gindre C, Swendsen JD, van Os J (2003). Cannabis use and dimensions of psychosis in a nonclinical population of female subjects. Schizophrenia Research 59, 77-84. (Pubitemid 35284497)
60. Wiles NJ, Zammit S, Bebbington P, Singleton N, Meltzer H, Lewis G (2006). Self-reported psychotic symptoms in the general population: results from the longitudinal study of the British National Psychiatric Morbidity Survey. British Journal of Psychiatry 188, 519-526. (Pubitemid 43844098)
61. Yung AR, Nelson B, Baker K, Buckby JA, Baksheev G, Cosgrave EM (2009). Psychotic-like experiences in a community sample of adolescents: implications for the continuum model of psychosis and prediction of schizophrenia. Australian and New Zealand Journal of Psychiatry 43, 118-128.