Cycloartanes from Euphorbia aellenii rech. f. and their antiproliferative activity

Iranian Journal of Pharmaceutical Research

Volumn 10, Issue 1, 2011, Pages 105-112

  Ayatollahi, Abdul Majid ^a   Ghanadian, Mustafa ^b   Afsharypuor, Suleiman ^b   Mesaik, M Ahmad ^c   Abdalla, Omer Mohamed ^c   Shahlaei, Mohsen ^d   Farzandi, Gholamhossein ^e   Mostafavi, Hamid ^e  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF KARACHI   (Pakistan)

^d KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Cycloartanes; Euphorbia aellenii; Proliferation assay; Protein kinase c (PKC); Structure activity relationship (SAR)

Indexed keywords

24 METHYLENE CYCLOARTAN 3BETA OL; 3BETA O ACETYL 24 METHYLENE CYCLOARTAN; 3BETA,24 O DIACETYL CYCLOART 25 EN; CYCLOART 25 EN 3BETA,24 DIOL; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; EUPHORBIA; EUPHORBIA AELLENII; HUMAN; HUMAN CELL; IMMUNOMODULATION; MOLECULAR DOCKING; PERIPHERAL LYMPHOCYTE; SPECTROSCOPY;

EID: 79955980603     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Dey PM and Harborne JB. Plant Biochemistry. Academic Press, London (1997) 422-423.
2. Heywood VH. Flowering Plants of the World. BT Batsford Ltd, London (1978) 185-187.
3. Isakov N and Altman N. Human T lymphocyte activation by tumor promoters: role of protein kinase C. J. Immunol. (1987) 138: 3100-3107.
4. Ayatollahi AM, Ghanadian M, Afsharypuor S, Siddiq S and Pour-hosseini SM. Biological screening of Euphorbia aellenii. Iranian J. Pharm. Res. (2010) 11: 429-436.
5. Dominguez-Carmona DB, Escalante-Erosa F, Garcia-Sosa K and Ruiz-Pinell G. Antiprotozoal activity of betulinic acid derivatives. Phytomedicine (2009) 17: 379-82.
6. Ayatollahi AM, Ghanadian M, Mesaik MA, Omer MA, Afsharypuor S, Kobarfard F and Mirza-taheri M. New myrsinane-type diterpenoids from Euphorbia aellenii Rech. f. with their immunomodulatory activity. Journal of Asian Nat. Prod. Res. (2010) 12: 1020-1025.
7. Gasteiger J and Marsili M. Iterative partial equalization of orbital electronegativity- a rapid access to atomic charges. Tetrahedron (1980) 36: 3219-3228.
8. Weiner SJ, Kollman PA, Case DA, Singh UC, Ghio C, Alagona G, Profeta S and Weiner P. A new force-field for molecular mechanical simulation of nucleic-acids and proteins. J. Am. Chem. Soc. (1984) 106: 765-784.
9. Morris GM, Goodsell DS, Halliday RS, Huey R, Hart WE, Belew RK and Olson A. Automated docking using a lamarckian genetic algorithm and an empirical binding free energy function. J. Comput. Chem. (1998) 19: 1639-1662.
10. Solis FJ and Wets JB. Minimization by random search techniques. Math. Oper. Res. (1981) 6: 19-30.
11. Humphrey W, Dalke A and Schulten K. VMD: Visual molecular dynamics. J. Mol. Graph. (1996) 14: 33-38.
12. Ayatollahi SAM, Ahmad Z, Afza N and Badar Y. A new cycloartane type teriterpene from Euphorbia clarkeana. J. Nat. Prod. (1992) 55: 959-961.
13. Oksuz S, Ulebelen A and Barla A. Terpenoids and aromatic compounds from Euphorbia heteradena. Turk. J. Chem. (2002) 26: 457-463.
14. Smith-Kielland I, Dornish JM, Malterud KE, Hvistendahl G, Rømming C, Bøckman OC, Kolsaker P, Stenstrøm Y and Nordal A. Cytotoxic triterpenoids from the leaves of Euphorbia pulcherrima. Planta Med. (1996) 62: 322-5.
15. Akihisa T, Yasukawa K, Oinuma H, Kasahara Y, Yamanouchi S, Takido M, Kumaki K and Tamura T. Triterpene alcohols from the flowers of Compositae and their anti-inflammatory effects. Phytochem. (1996) 43: 1255-1260.
16. Nissink JWM, Murray C, Hartshorn M, Verdonk ML, Cole JC and Taylor R. A new test set for validating predictions of protein-ligand interaction. Proteins: Struct. Funct. Genet. (2002) 49: 457-471.