Effect of multiple doses of fimasartan, an angiotensin II receptor antagonist, on the steady-state pharmacokinetics of digoxin in healthy volunteers

International Journal of Clinical Pharmacology and Therapeutics

Volumn 49, Issue 5, 2011, Pages 321-327

  Yi, S ^a   Kim, J W ^a   Kim, T E ^a   Kim, J ^a   Jun, Y K ^a   Choi, J ^a   Yoon, S H ^a   Cho, J Y ^a   Song, S H ^a   Shin, S G ^a   Jang, I J ^a   Yu, K S ^a  

^a Seoul National University Hospital   (South Korea)

Author keywords

Digoxin pharmacokinetics; Drug drug interaction; Fimasartan

Indexed keywords

DIGOXIN; FIMASARTAN;

ABDOMINAL PAIN; ACNE; ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DIZZINESS; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG URINE LEVEL; HEADACHE; HEART DISEASE; HEART PALPITATION; HUMAN; HUMAN EXPERIMENT; KOREA; LOADING DRUG DOSE; LOW BACK PAIN; MALE; MAXIMUM PLASMA CONCENTRATION; MEDIASTINUM DISEASE; MORNING DOSAGE; MULTIPLE DRUG DOSE; MUSCULOSKELETAL DISEASE; NAUSEA; NEUROLOGIC DISEASE; NORMAL HUMAN; NOSE CONGESTION; OPEN STUDY; POSITIONAL DIZZINESS; RESPIRATORY TRACT DISEASE; SORE THROAT; STEADY STATE; THORAX DISEASE; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT DURATION;

ADULT; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; AREA UNDER CURVE; ARRHYTHMIAS, CARDIAC; BIPHENYL COMPOUNDS; CARDIOTONIC AGENTS; CROSS-OVER STUDIES; DIGOXIN; FEMALE; HEART FAILURE; HUMANS; MALE; PYRIMIDINES; TETRAZOLES; YOUNG ADULT;

EID: 79955975563     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CP201533     Document Type: Article

References (15)

1. Canarb® (Fimasartan 120 mg) (Package insert), Boryung Pharmaceutical. Seoul, South Korea; 2010.
2. Digosin® (Digoxin 0.25 mg) (Package insert), CJ Pharmaceutical. Seoul, South Korea; 2009.
3. Evaluation of fimasartan as potential substrate for ABC and SLC transporter system (Internal report). Department of Pharmacology, Yonsei University Colleage of Medicine; 2009.
4. Angirasa AK, Koch AZ, P-glycoprotein as the mediator of itraconazole-digoxin interaction. J Am Podiatr Med Assoc. 2002; 92: 471-472.
5. Boyd RA, Stern RH; Stewart BH, Wu X, Reyner EL, Zegarac EA, Randinitis EJ, Whitfield L, Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glyco- protein-mediated secretion. J Clin Pharmacol. 2000; 40: 91-98.
6. Burton M, Shaw L, Schentag J, Evans W. Applied pharmacokinetics & pharmacodynamics: principles of therapeutic drug monitoring. Philadelphia: Lippincott Williams & Wilkins; 2006.
7. Chung YJ, Kim JR, Lim KS, Kim JW, Kim BH, Kim MG, Kim TE, Cho JY, Yu KS, Shin SG, Yang IY. Pharmacokinetic and pharmacodynamic profiles of BR-A657, a selective at 1 receptor antagonist, in patients with essential hypertension. Clin Phar Ther. 2007; 81: S108.
8. De Smet M, Schoors DF, De Meyer G, Verbesselt R, Goldberg MR, Fitzpatrick V, Somers G. Effect of multiple doses of losartan on the pharmacokinetics of single doses of digoxin in healthy volunteers. Br J Clin Pharmacol. 1995; 40: 571-575. (Pubitemid 26005562)
9. Lane A, Engmann E, Bryson S, Lee J, Tan H, Chi Y. Single dose pharmacokinetics (PK) and pharmacodynamics (PD) of BR-A-657, an angiotensin II (AII) antagonist Clin Phar Ther. 2005; 77: P59.
10. Lane A, Kleinermanns D, Bryson S, Lee J, Tan H, Chi Y. Multiple dose pharmacokinetics (PK) and pharmacodynamics (PD) of BR-A-657, an angiotensin II (AII) antagonist Clin Phar Ther. 2005; 77: P58.
11. Martin DE, Tompson D, Boike SC, Tenero D, Ilson B, Citerone D, Jorkasky DK. Lack of effect of eprosartan on the single dose pharmacokinetics of orally administered digoxin in healthy male volunteers. Br J Clin Pharmacol. 1997; 43: 661-664. (Pubitemid 27283579)
12. Schmitt C, Kaeser B, Riek M, Bech N, Kreuzer C, Effect of saquinavir/ritonavir on P-glycoprotein activity in healthy volunteers using digoxin as a probe. Int J Clin Pharmacol Ther. 2010; 48: 192-199.
13. Sechaud R, Robeva A, Belleli R, Balez S, Absence of an effect of a single-dose deferasirox on the steady-state pharmacokinetics of digoxin. Int J Clin Pharmacol Ther. 2008; 46: 519-526.
14. Stangier J, Sit CA, Hendriks MG, van Lier JJ, Sollie FA, Oosterhuis B, Jonkman JH, The effect of telmisartan on the steady-state pharmacokinetics of digoxin in healthy male volunteers. J Clin Pharmacol. 2000; 40: 1373-1379.
15. Tuncok Y, Hazan E, Oto O, Guven H, Catalyurek H, Kalkan S, Relationship between high serum digoxin levels and toxicity. Int J Clin Pharmacol Ther. 1997; 35: 366-368. (Pubitemid 27417675)