Follicle-stimulating hormone receptor (FSHR)-derived peptide vaccine induced infertility in mice without pathological effect on reproductive organs

Reproduction, Fertility and Development

Volumn 23, Issue 4, 2011, Pages 544-550

  Yang, Li Hua ^a   Li, Jin Tao ^a   Yan, Ping ^a   Liu, Hong Li ^a   Zeng, Su Yun ^a   Wu, Yu Zhang ^a   Liang, Zhi Qing ^a   He, Wei ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

contraceptive vaccine; immunisation; pathological damage; spermatogonia

Indexed keywords

CONTRACEPTIVE VACCINE; FOLLITROPIN RECEPTOR BINDING INHIBITOR; ISOLEUCYLGLUTAMYLLEUCYLARGINYLPHENYLALANYLVALYLLEUCYLTHREONYLLYSYLLEUCYLARGINYLVALYLISOLEUCINE; PEPTIDE VACCINE; UNCLASSIFIED DRUG;

ANTIBODY RESPONSE; ARTICLE; CELL DEATH; CELL SWELLING; FEMALE; GENITAL SYSTEM; HISTOLOGY; HUMAN; HUMAN TISSUE; INFERTILITY; LEYDIG CELL; MALE; MOUSE; NONHUMAN; SEMEN ANALYSIS; SEMINIFEROUS TUBULE; SPERMATOGONIUM;

ANIMALS; FEMALE; GENITAL DISEASES, MALE; GENITALIA, MALE; HUMANS; INFERTILITY, MALE; MALE; MICE; MICE, INBRED BALB C; PEPTIDE FRAGMENTS; RECEPTORS, FSH; SEMEN ANALYSIS; SPERM-OVUM INTERACTIONS; VACCINES, CONTRACEPTIVE;

MUS;

EID: 79955972655     PISSN: 10313613     EISSN: 14485990     Source Type: Journal    
DOI: 10.1071/RD10142     Document Type: Article

References (25)

1. Alexander, J., Sidney, J., Southwood, S., Ruppert, J., Oseroff, C., Maewal, A., Snoke, K., Serra, H. M., Kubo, R. T., Sette, A., and Grey, H. M. (1994). Development of high-potency universal DR-restricted helper epitopes by modification of high-affinity DR-blocking peptides. Immunity 1, 751-761. doi:10.1016/S1074-7613(94)80017-0
2. Amory, J. K., and Bremner, W. (2001). Endocrine regulation of testicular function in men: implications for contraceptive development. Mol. Cell. Endocrinol. 182, 175-179. doi:10.1016/S0303-7207(01)00562-7 (Pubitemid 32758770)
3. Foulkes, N. S., Schlotter, F., Pevet, P., and Sassone-Corsi, P. (1993). Pituitary hormone FSH directs the CREM functional switch during spermatogenesis. Nature 362, 264-267. doi:10.1038/362264A0 (Pubitemid 23093635)
4. Fritz, I. B., Griswold, M. D., Louis, B. G., and Dorrington, J. H. (1978). Metabolic responses of Sertoli cells in culture to various concentrations of follicle-stimulating hormone and cholera toxin. Can. J. Biochem. 56, 875-879. doi:10.1139/O78-135 (Pubitemid 9038165)
5. Itoh, M., Hiramine, C., Tokunaga, Y., Mukasa, A., and Hojo, K. (1991). A new murine model of autoimmune orchitis induced by immunization with viable syngeneic testicular germ cells alone: II. Immunohistochemical findings of fully developed inflammatory lesion. Autoimmunity 10, 89-97. doi:10.3109/ 08916939109004812
6. Krishnamurthy, H., Babu, P. S., Morales, C. R., and Sairam, M. R. (2001). Delay in sexual maturity of the follicle-stimulating hormone receptor knockout male mouse. Biol. Reprod. 65, 522-531. doi:10.1095/BIOL REPROD65.2.522 (Pubitemid 32702317)
7. Lu, Q., and Shur, B. D. (1997). Sperm from beta 1,4- galactosyltransferasenull mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly. Development 124, 4121-4131. (Pubitemid 27483337)
8. Makler, A. (1980). The improved ten-micrometer chamber for rapid sperm count and motility evaluation. Fertil. Steril. 33, 337-338. (Pubitemid 10153751)
9. Meduri, G., Bachelot, A., Cocca, M. P., Vasseur, C., Rodien, P., Kuttenn, F., Touraine, P., and Misrahi, M. (2008). Molecular pathology of the FSH receptor: new insights into FSH physiology. Mol. Cell. Endocrinol. 282, 130-142. doi:10.1016/J.MCE.2007.11.027
10. Moudgal, N. R., Ravindranath, N., Murthy, G. S., Dighe, R. R., Aravindan, G. R., and Martin, F. (1992). Long-term contraceptive efficacy of vaccine of ovine follicle-stimulating hormone in male bonnet monkeys (Macaca radiata). J. Reprod. Fertil. 96, 91-102. doi:10.1530/JRF.0. 0960091
11. Moudgal, N. R., Sairam, M. R., Krishnamurthy, H. N., Sridhar, S., Krishnamurthy, H., and Khan, H. (1997). Immunization of male bonnet monkeys (M. radiata) with a recombinant FSH receptor preparation affects testicular function and fertility. Endocrinology 138, 3065-3068. doi:10.1210/EN.138.7.3065 (Pubitemid 27258543)
12. Narula, A., Gu, Y. Q., O'Donnell, L., Stanton, P. G., Robertson, D. M., McLachlan, R. I., and Bremner, W. J. (2002). Variability in sperm suppression during testosterone administration to adult monkeys is related to follicle-stimulating hormone suppression and not to intratesticular androgens. J. Clin. Endocrinol. Metab. 87, 3399-3406. doi:10.1210/JC.87.7.3399 (Pubitemid 34816396)
13. Naz, R. K. (2009). Status of contraceptive vaccines. Am. J. Reprod. Immunol. 61, 11-18. doi:10.1111/J.1600-0897.2008.00663.X
14. Nechamen, C. A., and Dias, J. A. (2000). Human follicle-stimulating hormone receptor trafficking and hormone-binding sites in the amino terminus. Mol. Cell. Endocrinol. 166, 101-110. doi:10.1016/S0303-7207(00)00281-1
15. Panina-Bordignon, P., Tan, A., Termijtelen, A., Demotz, S., Corradin, G., and Lanzavecchia, A. (1989). Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur. J. Immunol. 19, 2237-2242. doi:10.1002/ EJI.1830191209 (Pubitemid 20024747)
16. Pieczenik, G. (2003). Are the universes of antibodies and antigens symmetrical? Reprod. Biomed. Online 6, 154-156. doi:10.1016/S1472-6483 (10)61702-6 (Pubitemid 36857137)
17. Rao, A. J., Ramachandra, S. G., Ramesh, V., Couture, L., Abdennebi, L., Salesse, R., and Remy, J. J. (2004). Induction of infertility in adult male bonnet monkeys by immunization with phage-expressed peptides of the extracellular domain of FSH receptor. Reprod. Biomed. Online 8, 385-391. doi:10.1016/S1472-6483(10)60921-2 (Pubitemid 38477186)
18. Reddy, P. S., and Pushpalatha, T. (2006). Reduction of spermatogenesis and steroidogenesis in mice after fentin and fenbutatin administration. Toxicol. Lett. 166, 53-59. doi:10.1016/J.TOXLET.2006.05.012 (Pubitemid 44279304)
19. Remy, J. J., Couture, L., Pantel, J., Haertle, T., Rabesona, H., Bozon, V., Pajot-Augy, E., Robert, P., Troalen, F., Salesse, R., and Bidart, J. M. (1996). Mapping of HCG-receptor complexes. Mol. Cell. Endocrinol. 125, 79-91. doi:10.1016/S0303-7207(96)03955-X (Pubitemid 27037787)
20. Subramanian, S., Karande, A. A., and Adiga, P. R. (2000). Immunocontraceptive potential of major antigenic determinants of chicken riboflavin carrier protein in the female rat. Vaccine 19, 1172-1179. doi:10.1016/S0264-410X(00)00311-X (Pubitemid 32008284)
21. Talbot, P., and Chacon, R. S. (1981). A triple-stain technique for evaluating normal acrosome reactions of human sperm. J. Exp. Zool. 215, 201-208. doi:10.1002/JEZ.1402150210
22. Tayama, K., Fujita, H., Takahashi, H., Nagasawa, A., Yano, N., Yuzawa, K., and Ogata, A. (2006). Measuring mouse sperm parameters using a particle counter and sperm quality analyser: a simple and inexpensive method. Reprod. Toxicol. 22, 92-101. doi:10.1016/J.REPROTOX.2005. 11.009 (Pubitemid 43963319)
23. Themmen, A. P. N., and Huhtaniemi, I. T. (2000). Mutations of gonadotrophins and gonadotrophin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocr. Rev. 21, 551-583. doi:10.1210/ER.21.5.551
24. Wickings, E. J., and Nieschlag, E. (1980). Suppression of spermatogenesis over two years in Rhesus monkeys actively immunized with folliclestimulating hormone. Fertil. Steril. 34, 269-274. (Pubitemid 10009517)
25. Yan, P., He, W., Liang, Z., Chen, Z., Shang, X., He, H., Tang, Y., Ni, B., Zhang, J., Shen, Z., Wu, Y., and Li, J. (2009a). A novel dominant B-cell epitope of FSHR identified by molecular docking induced specific immune response and suppressed fertility. Gynecol. Endocrinol. 25, 828-838. doi:10.1080/09513590903015536