The treatment of hypercholesterolemic children: Efficacy and safety of a combination of red yeast rice extract and policosanols

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 21, Issue 6, 2011, Pages 424-429

  Guardamagna, O ^a   Abello, F ^a   Baracco, V ^a   Stasiowska, B ^a   Martino, F ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Children; Dietary supplement; Hypercholesterolemia; Lipid lowering treatment; Red yeast rice extract

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; BIOLOGICAL PRODUCT; CHOLESTIN; FATTY ALCOHOL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; POLICOSANOL;

ADOLESCENT; ARTICLE; BLOOD; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG SCREENING; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MALE; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ANTICHOLESTEREMIC AGENTS; APOLIPOPROTEIN A-I; APOLIPOPROTEINS B; BIOLOGICAL PRODUCTS; CHILD; CHOLESTEROL, LDL; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRUG EVALUATION; FATTY ALCOHOLS; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; MALE;

EID: 79955972069     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2009.10.015     Document Type: Article

References (27)

1. Berenson G.S., Srinivasan S.R., Bao W., Newman W.P., Tracy R.E., Wattigney W.A., for the Bogalusa Heart Study Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. N Engl J Med 1998, 338:1650-1656.
2. Lauer R.M., Lee J., Clarke W.R. Factors affecting the relationship between childhood and adult cholesterol levels: the Muscatine Study. Pediatrics 1988, 82:309-318.
3. Charakida M., Deanfield J.E., Halcox J.P.J. Childhood origins of arterial disease. Curr Opin Pediatr 2007, 19:538-545.
4. McGill H.C., McMahan C.A., Herderick E.E., Malcom G.T., Tracy R.E., Strong J.P. Origin of atherosclerosis in childhood and adolescence. Am J Clin Nutr 2000, 72:1307S-1315S.
5. Daniels S.R., Greer F.R., the Committee on Nutrition Lipid screening and cardiovascular health in childhood. Pediatrics 2008, 122:198-208.
6. McCrindle B.W., Chair M.P.H., Urbina E.M., Jacobson M.S., Steinberger J., Rocchini A.P., et al. Drug therapy of high-risk lipid abnormalities in children and adolescents. A scientific statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, With the Council on Cardiovascular Nursing. Circulation 2007, 115:1948-1967.
7. Katan M.B., Grundy S.M., Jones P., La M., Miettinen T., Paoletti R., Stresa Workshop Participants Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 2003, 78:965-978.
8. Brown L., Rosner B., Willet W., Sacks F.M. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 1999, 69:30-42.
9. Mas R., Castano G., Illnait J., Fernández L., Fernández J., Alemán C., et al. Effects of policosanol in patients with type II hypercholesterolemia and additional coronary risk factors. Clin Pharmacol Ther 1999, 965:439-447.
10. Journoud M., Jones P.J.H. Red yeast rice: a new hypolipidemic drug. Life Sci 2004, 74:2675-2683.
11. Heber D., Yip I., Ashely J.M., Elashoff D.A., Elashoff R.M., Go V.L. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am J Clin Nutr 1999, 69:231-236.
12. Lin C.C., Li T.C., Lai M.M. Efficacy and safety of Monascus purpureus Went rice in subjects with hyperlipidemia. Eur J Endocrinol 2005, 153:679-686.
13. Huang C.F., Li T.C., Lin C.C., Liu C.S., Shih H.C., Lai M.M. Efficacy of Monascus purpureus Went rice on lowering lipid ratios in hypercholesterolemic patients. Eur J Cardiovasc Prev Rehabil 2007, 14:438-440.
14. Becker D.J., Gordon R.Y., Halbert S.C., French B., Morris P.B., Rader D.J. Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. Ann Intern Med 2009, 150:830-839.
15. Bertolini S., Cantafora A., Averna M., Cortese C., Motti C., Martini S., et al. Clinical expression of familial hypercholesterolemia in clusters of mutations of the LDL receptor gene that cause a receptor-defective or receptor-negative phenotype. Arterioscler Thromb Vasc Biol 2000, 20:e41-e52.
16. National Cholesterol Education Program (NCEP): Highlights of the Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. NCEP Expert Panel on Blood Cholesterol Levels in Children and Adolescents. Pediatrics 1992, 89:495-501.
17. Hills M., Armitage P. The two-period cross-over clinical trial. Br J Clin Pharmacol 1979, 8:7-20.
18. Gidding S.S., Dennison B.A., Birch L.L., Daniels S.R., Gillman M.W., Lichtenstein A.H., et al. Dietary recommendations for children and adolescents: a guide for practitioners. American Heart Association. Pediatrics 2006, 117:544-559.
19. Widhalm K., Brazda G., Schneider B., Kohl S. Effect of soy protein diet versus standard low fat, low cholesterol diet on lipid and lipoprotein levels in children with familial or polygenic hypercholesterolemia. J Pediatr 1993, 123:30-34.
20. Rask-Nissila L., Jokinen E., Rönnemaa T., Viikari J., Tammi A., Niinikoski H., et al. Prospective, randomized, infancy-onset trial of the effects of a low-saturated-fat, low-cholesterol diet on serum lipids and lipoproteins before school age: The Special Turku Coronary Risk Factor Intervention Project (STRIP). Circulation 2000, 102:1477-1483.
21. Liu J., Zhang J., Shi Y., Grimsgaard S., Alraek T., Fønnebø V. Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials. Chin Med 2006, 1:4.
22. Lapi F., Gallo E., Bernasconi S., Vietri M., Menniti-Ippolito F., Raschetti R., et al. Myopathies associated with red yeast rice and liquorice: spontaneous reports from the Italian Surveillance System of Natural Health Products. Br J Clin Pharmacol 2008, 66:572-574.
23. Prasad G.V.R., Wong T., Meliton G., Bhaloo S. Rhabdomyolysis due to red yeast rice (Monascus purpureus) in a renal transplant recipient. Transplantation 2002, 74:1200-1201.
24. Reiner Z., Tedeschi-Reiner E., Romic Z. Effects of rice policosanol on serum lipoproteins, homocysteine, fibrinogen and C-reactive protein in hypercholesterolemic patients. Clin Drug Investig 2005, 25:701-707.
25. Dulin M.F., Hatcher L.F., Sasser H.C., Barringer T.A. Policosanol is ineffective in the treatment of hypercholesterolemia: a randomized controlled trial. Am J Clin Nutr 2006, 84:1543-1548.
26. Greyling A., De Witt C., Oosthuizen W., Jerling J.C. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. BMJ 2006, 95:968-975.
27. Avis H.J., Vissers M.N., Stein E.A., Wijburg F.A., Trip M.D., Kastelein J.J., et al. A systematic review and meta-analysis of statin therapy in children with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2007, 27:1803-1810.