Predictors of mortality in verapamil overdose: Usefulness of serum verapamil concentrations

Basic and Clinical Pharmacology and Toxicology

Volumn 108, Issue 6, 2011, Pages 385-389

  Mégarbane, Bruno ^a,b   Karyo, Souheil ^a   Abidi, Khalid ^c   Delhotal Landes, Brigitte ^a   Aout, Mounir ^a   Sauder, Philippe ^c   Baud, Frédéric J ^a,b  

^a HÔPITAL LARIBOISIÈRE   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BICARBONATE; CALCIUM SALT; CHARCOAL; DIGOXIN; DIHYDROQUINIDINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOBUTAMINE; DOPAMINE; GLUCAGON; INSULIN; ISOPRENALINE; NORADRENALIN; TERLIPRESSIN; TRICYCLIC ANTIDEPRESSANT AGENT; VENLAFAXINE; VERAPAMIL;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; ATRIOVENTRICULAR BLOCK; DEATH; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG OVERDOSE; FATALITY; FEMALE; HEART ARREST; HEART SINOATRIAL BLOCK; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PATIENT MONITORING; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROGNOSIS; SHOCK;

ADULT; CALCIUM CHANNEL BLOCKERS; DELAYED-ACTION PREPARATIONS; FEMALE; HEART ARREST; HUMANS; INTENSIVE CARE; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; OVERDOSE; PROGNOSIS; TREATMENT OUTCOME; VERAPAMIL;

EID: 79955965758     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2010.00666.x     Document Type: Article

References (13)

1. Bronstein AC, Spyker DA, Cantilena LR Jr, Green JL, Rumack BH, Giffin SL. 2008 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 26th Annual Report. Clin Toxicol (Phila) 2009;47:911-1084.
2. Salhanick SD, Shannon MW. Management of calcium channel antagonist overdose. Drug Saf 2003;26:65-79.
3. Hofer CA, Smith JK, Tenholder MF. Verapamil intoxication: a literature review of overdoses and discussion of therapeutic options. Am J Med 1993;95:431-8.
4. Ashraf M, Chaudhary K, Nelson J, Thompson W. Massive overdose of sustained-release verapamil: a case report and review of literature. Am J Med Sci 1995;310:258-63.
5. Mégarbane B, Donetti L, Blanc T, Chéron G, Jacobs F; Groupe d'experts de la SRLF. Treatment of acute poisoning by illicit drugs Recommendations of the French Language Resuscitation Society (SRLF)]. Rev Prat 2008;58:871-81.
6. Leesar MA, Martyn R, Talley JD, Frumin H. Noncardiogenic pulmonary edema complicating massive verapamil overdose. Chest 1994;105:606-7.
7. Levine M, Boyer EW, Pozner CN, Geib AJ, Thomsen T, Mick N et al. Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil. Crit Care Med 2007;35:2071-5.
8. Chan LF, Chhuy LH, Crowley RJ. Verapamil tissue concentrations in fatal cases. J Anal Toxicol 1987;11:171-4.
9. Tuka V, Ricarova B, Janota T, Malik J, Kotrlikova E. Surprisingly delayed escalation of severe verapamil poisoning. Eur J Emerg Med 2009;16:100-2.
10. Wilimowska J, Piekoszewski W, Krzyanowska-Kierepka E, Florek E. Monitoring of verapamil enantiomers concentration in overdose. Clin Toxicol (Phila) 2006;44:169-71.
11. Kivistö KT, Neuvonen PJ, Tarssanen L. Pharmacokinetics of verapamil in overdose. Hum Exp Toxicol 1997;16:35-7.
12. Buckley CD, Aronson JK. Prolonged half-life of verapamil in a case of overdose: implications for therapy. Br J Clin Pharmacol 1995;39:680-3.
13. Sauder P, Kopferschmitt J, Dahlet M, Tritsch L, Flesch F, Siard P et al. [Acute verapamil poisoning. 6 cases. Review of the literature]. J Toxicol Clin Exp 1990;10:261-70.