The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation

Journal of Biological Chemistry

Volumn 286, Issue 20, 2011, Pages 17665-17671

  LeNoue Newton, Michele ^a   Watkins, Guy R ^a   Zou, Ping ^b   Germane, Katherine L ^b   McCorvey, Lisa R ^a   Wadzinski, Brian E ^a   Spiller, Benjamin W ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING DETERMINANT; BINDING DOMAIN; BINDING RESIDUES; C-TERMINAL DOMAINS; CATALYTIC SUBUNITS; CYCLOHEXIMIDES; DOUBLE ELECTRON-ELECTRON RESONANCE; MAMMALIAN CELLS; MULTIDOMAIN PROTEINS; N-TERMINAL DOMAINS; OPEN CONFORMATION; POLYUBIQUITINATION; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN PHOSPHATASE 2A; REGULATORY PROTEIN; UBIQUITIN LIGASES; UBIQUITIN-INTERACTING MOTIFS; UBIQUITINATION; WILD TYPES;

DEGRADATION; MAMMALS; PHOSPHATASES; X RAY CRYSTALLOGRAPHY;

PROTEINS;

ALPHA4 PROTEIN; CYCLOHEXIMIDE; PHOSPHOPROTEIN PHOSPHATASE 2A; REGULATOR PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; HUMAN; HUMAN CELL; PRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN STRUCTURE; REGULATORY MECHANISM; UBIQUITINATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PHOSPHOPROTEINS; PROTEIN PHOSPHATASE 2; PROTEIN STRUCTURE, TERTIARY; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

MAMMALIA;

EID: 79955958006     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.222414     Document Type: Article

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