Clinical efficacy of a novel new injectable diclofenac formulation designed for intradeltoid use in post-operative pain management

International Journal of Clinical Pharmacology and Therapeutics

Volumn 49, Issue 4, 2011, Pages 286-290

  Shah, P ^a   Subnis, B ^b   Varshney, A ^c   Pradhan, C ^d   Murthy, T V S P ^e   Shah, D ^f   Jaiswal, V ^f  

^a KEM HOSPITAL   (India)

^b SIR J J GROUP OF HOSPITALS   (India)

^c R G Stone Urological Research Centre   (India)

^d Sancheti Institute for Orthopaedics and Rehabilitation   (India)

^e ARMY HOSPITAL RESEARCH AND REFERRAL   (India)

^f Troikaa Pharmaceuticals Ltd   (India)

Author keywords

Analgesia; Injection diclofenac; Intra deltoid; Intragluteal; New formulation

Indexed keywords

DICLOFENAC; DYNAPAR AQ; UNCLASSIFIED DRUG;

ADULT; AGED; ANALGESIA; ARTICLE; CONTROLLED STUDY; DELTOID MUSCLE; DOSE TIME EFFECT RELATION; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GLUTEUS MAXIMUS MUSCLE; HUMAN; INJECTION SITE PAIN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPEN STUDY; PHASE 4 CLINICAL TRIAL; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL; VISUAL ANALOG SCALE;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; DICLOFENAC; FEMALE; HUMANS; INJECTIONS; MALE; MIDDLE AGED; PAIN MEASUREMENT; PAIN, POSTOPERATIVE;

EID: 79955953550     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CP201512     Document Type: Article

References (10)

1. Chan VO, Colville J, Persaud T et al. Intramuscular injections into the buttocks: are they truly intramuscular? Eur J Radiol. 2006; 58: 480-484.
2. Zaybak A, Güneş UY, Tamsel S, Khorshid L, Eşer I. Does obesity prevent the needle from reaching muscle in intramuscular injections? J Adv Nurs. 2007; 58: 552-556.
3. Tsai L. Taking the mystery out of medication in autism/Asperger's syndrome. Texas: Future Horizons Inc; 2001. p. 169.
4. Nisbet AC. Intramuscular gluteal injections in the increasingly obese population: retrospective study. BMJ. 2006; 332: 637-638. (Pubitemid 44365718)
5. Grabinski PY, Kaiko RF, Rogers AG, Houde RW. Plasma levels and analgesia following deltoid and gluteal injections of methadone and morphine. J Clin Pharmacol. 1983; 23: 48-55. (Pubitemid 13144036)
6. Subnis BM, Patel P, Pradhan CV et al. Evaluation of the effectiveness and safety of a new formulation of injecation diclofenac DYNAPAR AQ (75 mg/ml) in the management of post-operative pain - a study. Indian Medical Gazette. 2010; 6: 213-217.
7. Prabhakar H, Shrirao SA, Shelgaonkar VC, Ghosh AA. Comparative evaluation of intramuscular ketoprofen and diclofenac sodium for post-operative pain relief. The Internet Journal of Anesthesiology. 2006; 11.
8. Al-Waili NS. Efficacy and safety of repeated post-operative administration of intramuscular diclofenac sodium in the treatment of post-cesarean section pain: a double-blind study. Arch Med Res. 2001; 32: 148-154. (Pubitemid 32421564)
9. Shep D, Ojha A, Patel S, Nivsarkar M, Jaiswal V, Padh H. Pharmacokinetic profile of an intradeltoid diclofenac injection in obese Indian volunteers. J Pain Res. 2010; 3: 235-240.
10. Svendsen O, Blom L. Intramuscular injections and muscle damage: effects of concentration, volume, injection speed and vehicle. Arch Toxicol. 1984; 7 (Suppl): 472-475. (Pubitemid 14024652)