Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 2: Precorneal retention and in vivo pharmacodynamic study

International Journal of Pharmaceutics

Volumn 411, Issue 1-2, 2011, Pages 78-85

  Rupenthal, Ilva D ^a   Green, Colin R ^a   Alany, Raid G ^a,b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

Anionic polysaccharides; Gamma scintigraphy; In situ gelling systems; Ocular drug delivery; Ocular irritancy; Pharmacokinetic study

Indexed keywords

ALGINIC ACID; CARRAGEENAN; CHITOSAN; GELLAN; GELLING AGENT; HYDROXYPROPYLMETHYLCELLULOSE; PILOCARPINE; XANTHAN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLEEDING; BLOOD CLOTTING; CHORIOALLANTOIS; CONTROLLED STUDY; CORNEA; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG RESPONSE; DRUG RETENTION; EYE IRRITATION; HYPEREMIA; IN VIVO STUDY; ION EXCHANGE; MALE; MIOSIS; NONHUMAN; OCULAR DRUG DELIVERY SYSTEM; PRIORITY JOURNAL; PUPIL; RABBIT; RADIOACTIVITY;

ANIMALS; ANIONS; CARRAGEENAN; CORNEA; DRUG DELIVERY SYSTEMS; EXCIPIENTS; EYE; GELS; HUMANS; MALE; MIOTICS; OPHTHALMIC SOLUTIONS; PHYSICOCHEMICAL PHENOMENA; PILOCARPINE; POLYSACCHARIDES, BACTERIAL; RABBITS; VISCOSITY;

EID: 79955950052     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.03.043     Document Type: Article

References (19)

1. Alany, R.G., Rades, T., Nicoll, J., Tucker, I.G., Davies, N.M., 2006. W/O microemulsions for ocular delivery: evaluation of ocular irritation and precorneal retention. J. Control. Release 111, 145-152. (Pubitemid 43290003)
2. Chan, J., El Maghraby, G.M.M., Craig, J.P., Alany, R.G., 2007. Phase transition water-in- oil microemulsions as ocular drug delivery systems: in vitro and in vivo evaluation. Int. J. Pharm. 328, 65-71.
3. Durrani, A.M., Farr, S.J., Kellaway, I.W., 1995. Influence of molecular weight and formulation pH on the precorneal clearance rate of hyaluronic acid in the rabbit eye. Int. J. Pharm. 118, 243-250.
4. Greaves, J.L., Wilson, C.G., Birmingham, A.T., 1993. Assessment of the precorneal residence of an ophthalmic ointment in healthy subjects. Br. J. Clin. Pharmacol. 35, 188-192.
5. Greaves, J.L., Wilson, C.G., Rozier, A., Grove, J., Plazonnet, B., 1990. Scintigraphic assessment of an ophthalmic gelling vehicle in man and rabbit. Curr. Eye Res. 9, 415-420.
6. Gupta, H., Velpandian, T., Jain, S., 2010. Ion- and pH-activated novel in-situ gel system for sustained ocular drug delivery. J. Drug Target. 18, 499-505.
7. Hassan, E.E., Gallo, J.M., 1990. A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength. Pharm. Res. 7, 491-495.
8. Lehr, C.-M., Bouwstra, J.A., Schacht, E.H., Junginger, H.E., 1992. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J. Pharm. 78, 43-48.
9. Leung, S.-H.S., Robinson, J.R., 1988. The contribution of anionic polymer structural features to mucoadhesion. J. Control. Release 5, 223-231. (Pubitemid 18038211)
10. Liu, Z., Li, J., Nie, S., Liu, H., Ding, P., Pan, W., 2006. Study of an alginate/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacin. Int. J. Pharm. 315, 12-17.
11. Luepke, N.P., 1985. Hen's egg chorioallantoic membrane test for irritation potential. Food Chem. Toxicol. 23, 287-291.
12. Meseguer, G., Gurny, R., Buri, P., Rozier, A., Plazonnet, B., 1993. Gamma scintigraphic study of precorneal drainage and assessment of miotic response in rabbits of various ophthalmic formulations containing pilocarpine. Int. J. Pharm. 95, 229-234.
13. Nagarsenker, M.S., Londhe, V.Y., Nadkarni, G.D., 1999. Preparation and evaluation of liposomal formulations of tropicamide for ocular delivery. Int. J. Pharm. 190, 63-71.
14. Rossomondo, R.M., Carlton, W.H., Trueblood, J.H., Thomas, R.P., 1972. A new method of evaluating lacrimal drainage. Arch. Ophthalmol. 88, 523-525.
15. Rupenthal, I.D., et al., 2011. Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 1: Physicochemical characterisation and in vitro release. Int. J. Pharm., doi:10.1016/j.ijpharm. 2011.03.042.
16. Snibson, G.R., Greaves, J.L., Soper, N.D., Tiffany, J.M., Wilson, C.G., Bron, A.J., 1992. Ocular surface residence times of artificial tear solutions. Cornea 11, 288-293.
17. Urtti, A., Salminen, L., 1993. Animal pharmacokinetic studies. In: Mitra, A.K. (Ed.), Ophthalmic Drug Delivery Systems. Marcel Dekker, New York, pp. 121-136.
18. Wei, G., Xu, H., Ding, P.T., Li, S.M., Zheng, J.M., 2002. Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies. J. Control. Release 83, 65-74. (Pubitemid 35239815)
19. Wilson, C.G., 1999. Assessing ocular drug delivery with lachrimal scintigraphy. Pharm. Sci. Technol. Today 2, 321-326.