Regulation of longevity by regulator of G-protein signaling protein, Loco

Aging Cell

Volumn 10, Issue 3, 2011, Pages 438-447

  Lin, Yuh Ru ^a   Kim, Keetae ^a,b   Yang, Yanfei ^a   Ivessa, Andreas ^a   Sadoshima, Junichi ^a   Park, Yongkyu ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

G protein signaling; Loco; Longevity; Nutritional content; Regulator of G protein signaling protein; Stress resistance

Indexed keywords

COMPLEMENTARY DNA; CYCLIC AMP; ENZYME ACTIVATOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; LOCO PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; RGS PROTEIN; RGS14 PROTEIN; RGS2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; FAT CONTENT; FEMALE; FLY; GENE ACTIVITY; GENE DELETION; GENOMICS; HEAT TOLERANCE; LONGEVITY; MALE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; STARVATION; STRESS;

ADIPOSE TISSUE; ANIMALS; CONSERVED SEQUENCE; CYCLIC AMP; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; FIBROBLASTS; GENE EXPRESSION; GTP PHOSPHOHYDROLASE ACTIVATORS; LONGEVITY; MALE; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; RATS; RGS PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE DELETION; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; SUPEROXIDE DISMUTASE;

DROSOPHILA MELANOGASTER; MAMMALIA; RATTUS; SACCHAROMYCES CEREVISIAE;

EID: 79955944455     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00678.x     Document Type: Article

References (41)

1. Berman DM, Wilkie TM, Gilman AG (1996) GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell 86, 445-452.
2. Brüning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR (2000) Role of brain insulin receptor in control of body weight and reproduction. Science 289, 2122-2125.
3. Chavous DA, Jackson FR, O'Connor CM (2001) Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase. Proc. Natl Acad. Sci. USA 98, 14814-14818.
4. Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-106.
5. Clark AG, Keith LE (1988) Variation among extracted lines of Drosophila melanogaster in triacylglycerol and carbohydrate storage. Genetics 119, 595-607.
6. Colombo S, Ma P, Cauwenberg L, Winderickx J, Crauwels M, Teunissen A, Nauwelaers D, de Winde JH, Gorwa MF, Colavizza D, Thevelein JM (1998) Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae. EMBO J. 17, 3326-3341.
7. Djawdan M, Sugiyama TT, Schlaeger LK, Bradley TJ, Rose MR (1996) Metabolic aspects of the trade-off between fecundity and longevity in Drosophila melanogaster. Physiol. Zool. 69, 1176-1195.
8. Djawdan M, Chippindale AK, Rose MR, Bradley TJ (1998) Metabolic reserves and evolved stress resistance in Drosophila melanogaster. Physiol. Zool. 71, 584-594.
9. Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD (2001) Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-290.
10. Fabrizio P, Liou LL, Moy VN, Diaspro A, Valentine JS, Gralla EB, Longo VD (2003) SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics 163, 35-46.
11. Fontana L, Partridge L, Longo VD (2010) Extending healthy life span - from yeast to humans. Science 328, 321-326.
12. Formstecher E, Aresta S, Collura V, Hamburger A, Meil A, Trehin A, Reverdy C, Betin V (2005) Protein interaction mapping: a Drosophila case study. Genome Res. 15, 376-384.
13. Fowler K, Partridge L (1989) A cost of mating in female fruitflies. Nature 338, 760-761.
14. Glick JL, Meigs TE, Miron A, Casey PJ (1998) RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. J. Biol. Chem. 273, 26008-26013.
15. Granderath S, Stollewerk A, Greig S, Goodman CS, O'Kane CJ, Klambt C (1999) loco encodes an RGS protein required for Drosophila glial differentiation. Development 126, 1781-1791.
16. i GTPase activity. Nature 383, 175-177.
17. Kaeberlein M, Powers 3rd RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK (2005) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196.
18. Kaplow ME, Korayem AH, Venkatesh TR (2008) Regulation of glia number in Drosophila by Rap/Fzr, an activator of the anaphase-promoting complex, and Loco, an RGS protein. Genetics 178, 2003-2016.
19. Kim K, Lin YR, Park Y (2010) Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster. Exp. Gerontol. 45, 984-987.
20. i interaction sites with guanine nucleotide dissociation inhibitor activity. J. Biol. Chem. 276, 29275-29281.
21. Kimple ME, Joseph JW, Bailey CL, Fueger PT, Hendry IA, Newgard CB, Casey PJ (2008) Galphaz negatively regulates insulin secretion and glucose clearance. J. Biol. Chem. 283, 4560-4567.
22. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946.
23. Kirby K, Hu J, Hilliker AJ, Phillips JP (2002) RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress. Proc. Natl Acad. Sci. USA 99, 16162-16167.
24. Lin YJ, Seroude L, Benzer S (1998) Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 282, 943-946.
25. McGurk L, Pathirana S, Rothwell K, Trimbuch T, Colombini P, Yu F, Chia W, Bownes M (2008) The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster. BMC Dev. Biol. 8, 37.
26. Neer EJ (1995) Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80, 249-257.
27. Neubig RR, Siderovski DP (2002) Regulators of G-protein signalling as new central nervous system drug targets. Nat. Rev. Drug Discov. 1, 187-197.
28. Park SW, Oh H, Lin YR, Park Y (2010) MSL cis-spreading from roX gene up-regulates the neighboring genes. Biochem. Biophys. Res. Commun. 399, 227-231.
29. Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL (1998) Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat. Genet. 19, 171-174.
30. Partridge L, Farquhar M (1981) Sexual activity reduces lifespan of male fruitflies. Nature 294, 580-582.
31. Pathirana S, Zhao D, Bownes M (2001) The Drosophila RGS protein Loco is required for dorsal/ventral axis formation of the egg and embryo, and nurse cell dumping. Mech. Dev. 109, 137-150.
32. Rogina B, Reenan RA, Nilsen SP, Helfand SL (2000) Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 290, 2137-2140.
33. Schwabe T, Bainton RJ, Fetter RD, Heberlein U, Gaul U (2005) GPCR signaling is required for blood-brain barrier formation in Drosophila. Cell 123, 133-144.
34. Shu FJ, Ramineni S, Hepler JR (2010) RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. Cell. Signal. 22, 366-376.
35. Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107-110.
36. Toda T, Uno I, Ishikawa T, Powers S, Kataoka T, Broek D, Cameron S, Broach J, Matsumoto K, Wigler M (1985) In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell 40, 27-36.
37. Vermeulen CJ, Loeschcke V (2007) Longevity and the stress response in Drosophila. Exp. Gerontol. 42, 153-159.
38. Versele M, de Winde JH, Thevelein JM (1999) A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. EMBO J. 18, 5577-5591.
39. Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, Li X, Sowa NA, Kimple RJ, Doyle DA, Der CJ, Zylka MJ, Snider WD, Siderovski DP (2009) Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PLoS ONE 4, e4884.
40. Yan L, Vatner DE, O'Connor JP, Ivessa A, Ge H, Chen W, Hirotani S, Ishikawa Y, Sadoshima J, Vatner SF (2007) Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 130, 247-258.
41. Yu F, Wang H, Qian H, Kaushik R, Bownes M, Yang X, Chia W (2005) Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions. Genes Dev. 19, 1341-1353.