Co-loading of bisphosphonates and antibiotics to a biomimetic hydroxyapatite coating

Biotechnology Letters

Volumn 33, Issue 6, 2011, Pages 1265-1268

  Forsgren, Johan ^a   Brohede, Ulrika ^b   Strømme, Maria ^a   Engqvist, Håkan ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b SANDVIK AB   (Sweden)

Author keywords

Antibiotics; Bisphosphonates; Hydroxyapatite; Sustained release

Indexed keywords

BIOLOGICAL EFFECTS; BISPHOSPHONATES; CEPHALOTHIN; COATING SURFACE; HYDROXYAPATITE COATING; HYDROXYAPATITE IMPLANTS; IMPLANT STABILITY; SUSTAINED RELEASE;

APATITE; BIOMIMETICS; COATINGS; DRUG INTERACTIONS; HYDROXYAPATITE;

ANTIBIOTICS;

ANTIINFECTIVE AGENT; BIOMATERIAL; BIOMIMETIC MATERIAL; BISPHOSPHONIC ACID DERIVATIVE; CEFALOTIN; CLODRONIC ACID; HYDROXYAPATITE;

ARTICLE; BIOMIMETICS; BIOTECHNOLOGY; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG IMPLANT; HUMAN; INFECTION; MATERIALS TESTING; SURFACE PROPERTY;

ANTI-BACTERIAL AGENTS; BIOMIMETIC MATERIALS; BIOMIMETICS; BIOTECHNOLOGY; CEPHALOTHIN; CLODRONIC ACID; COATED MATERIALS, BIOCOMPATIBLE; DELAYED-ACTION PREPARATIONS; DIPHOSPHONATES; DRUG IMPLANTS; DURAPATITE; HUMANS; MATERIALS TESTING; PROSTHESIS-RELATED INFECTIONS; SURFACE PROPERTIES;

EID: 79955942313     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-011-0542-7     Document Type: Article

References (14)

1. Åberg J, Brohede U, Mihranyan A, Strømme M, Engqvist H (2009) Bisphosphonate incorporation in surgical implant coatings by fast loading and co-precipitation at low drug concentrations. J Mater Sci Mater Med 20: 2053-2061.
2. Barrere F, van der Valk CM, Meijer G, Dalmeijer RAJ, de Groot K, Layrolle P (2003) Osteointegration of biomimetic apatite coating applied onto dense and porous metal implants in femurs of goats. J Biomed Mater Res B 67B: 655-665.
3. Brohede U, Forsgren J, Roos S, Mihranyan A, Engqvist H, Strømme M (2009a) Multifunctional implant coatings providing possibilities for fast antibiotics loading with subsequent slow release. J Mater Sci Mater Med 20: 1859-1867.
4. Brohede U, Zhao SX, Lindberg F, Mihranyan A, Forsgren J, Strømme M, Engqvist H (2009b) A novel graded bioactive high adhesion implant coating. Appl Surf Sci 255: 7723-7728.
5. Campoccia D, Montanaro L, Arciola CR (2006) The significance of infection related to orthopedic devices and issues of antibiotic resistance. Biomaterials 27: 2331-2339.
6. Carreon LY, Puno RM, Dimar JR, Glassman SD, Johnson JR (2003) Perioperative complications of posterior lumbar decompression and arthrodesis in older adults. J Bone Joint Surg Am 85A: 2089-2092.
7. Gao Y, Zou SJ, Liu XG, Bao CY, Hu J (2009) The effect of surface immobilized bisphosphonates on the fixation of hydroxyapatite-coated titanium implants in ovariectomized rats. Biomaterials 30: 1790-1796.
8. Gristina AG (1994) Implant failure and the immune-incompetent fibro-inflammatory zone. Clin Orthop Relat Res 298: 106-118.
9. Lavernia CJ, Drakeford MK, Tsao AK, Gittelsohn A, Krackow KA, Hungerford DS (1995) Revision and primary hip and knee arthroplasty-a cost-analysis. Clin Orthop Relat Res 311: 136-141.
10. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR (1999) Guideline for prevention of surgical site infection, 1999. Infect Control Hosp Epidemiol 20: 250-278.
11. McLeod K, Kumar S, Smart RSC, Dutta N, Voelcker NH, Anderson GI, Sekel R (2006) XPS and bioactivity study of the bisphosphonate pamidronate adsorbed onto plasma sprayed hydroxyapatite coatings. Appl Surf Sci 253: 2644-2651.
12. Pulido L, Ghanem E, Joshi A, Purtill JJ, Parvizi J (2008) Periprosthetic joint infection: the incidence, timing, and predisposing factors. Clin Orthop Relat Res 466: 1710-1715.
13. Schmidmaier G, Lucke M, Wildemann B, Haas NP, Raschke M (2006) Prophylaxis and treatment of implant-related infections by antibiotic-coated implants: a review. Injury 37: 105-112.
14. Stigter M, Bezemer J, de Groot K, Layrolle P (2004) Incorporation of different antibiotics into carbonated hydroxyapatite coatings on titanium implants, release and antibiotic efficacy. J Controlled Release 99: 127-137.