APOBEC3-mediated hypermutation of retroviral vectors produced from some retrovirus packaging cell lines

Gene Therapy

Volumn 18, Issue 5, 2011, Pages 528-530

  Miller, A D ^a   Metzger, M J ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

APOBEC3; mutagenesis; retroviral vectors; retrovirus packaging cells

Indexed keywords

APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; HYDROLASE; RETROVIRUS VECTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RETROVIRUS PACKAGING CELL FLYA13; REVERSE TRANSCRIPTION; VIRION; VIRUS MUTATION;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CYTOSINE DEAMINASE; FIBROSARCOMA; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; MICE; MUTAGENESIS; RETROVIRIDAE;

EID: 79955939275     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2010.177     Document Type: Article

References (20)

1. Harris RS, Bishop KN, Sheehy AM, Craig HM, Petersen-Mahrt SK, Watt IN et al. DNA deamination mediates innate immunity to retroviral infection. Cell 2003; 113: 803-809. (Pubitemid 36724943)
2. Miller AD. Development and applications of retroviral vectors. In: Coffin JM, Hughes SH, Varmus HE (eds). Retroviruses. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, 1997, pp 437-473.
3. Metzger MJ, Miller AD. Acutely transforming retrovirus expressing Nras generated from HT-1080 fibrosarcoma cells infected with the human retrovirus XMRV. J Virol 2010; 84: 7908-7910.
4. Miller DG, Edwards RH, Miller AD. Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus. Proc Natl Acad Sci USA 1994; 91: 78-82. (Pubitemid 24018646)
5. Cosset FL, Takeuchi Y, Battini JL, Weiss RA, Collins MK. High-titer packaging cells producing recombinant retroviruses resistant to human serum. J Virol 1995; 69: 7430-7436.
6. Miller AD, Chen F. Retrovirus packaging cells based on 10A1 murine leukemia virus for production of vectors that use multiple receptors for cell entry. J Virol 1996; 70: 5564-5571. (Pubitemid 26240733)
7. Miller AD, Garcia JV, von Suhr N, Lynch CM, Wilson C, Eiden MV. Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus. J Virol 1991; 65: 2220-2224.
8. Kinomoto M, Kanno T, Shimura M, Ishizaka Y, Kojima A, Kurata T et al. All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition. Nucleic Acids Res 2007; 35: 2955-2964. (Pubitemid 47073634)
9. Sheehy AM, Gaddis NC, Choi JD, Malim MH. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 2002; 418: 646-650.
10. Pizzato M, Merten OW, Blair ED, Takeuchi Y. Development of a suspension packaging cell line for production of high titre, serum-resistant murine leukemia virus vectors. Gene Therapy 2001; 8: 737-745. (Pubitemid 32509787)
11. Browne EP, Littman DR. Species-specific restriction of Apobec3-mediated hypermuta-tion. J Virol 2008; 82: 1305-1313.
12. Low A, Okeoma CM, Lovsin N, de las Heras M, Taylor TH, Peterlin BM et al. Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene. Virology 2009; 385: 455-463.
13. Rulli Jr SJ, Mirro J, Hill SA, Lloyd P, Gorelick RJ, Coffin JM et al. Interactions of murine APOBEC3 and human APOBEC3G with murine leukemia viruses. J Virol 2008; 82: 6566-6575. (Pubitemid 351875133)
14. Takeda E, Tsuji-Kawahara S, Sakamoto M, Langlois MA, Neuberger MS, Rada C et al. Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo. J Virol 2008; 82: 10998-11008.
15. Miller AD, Buttimore C. Redesign of retrovirus packaging cell lines to avoid recombina¬tion leading to helper virus production. Mol Cell Biol 1986; 6: 2895-2902.
16. Koning FA, Newman EN, Kim EY, Kunstman KJ, Wolinsky SM, Malim MH. Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets. J Virol 2009; 83: 9474-9485.
17. Quade K. Transformation of mammalian cells by avian myelocytomatosis virus and avian erythroblastosis virus. Virology 1979; 98: 461-465. (Pubitemid 10191226)
18. Shaw G, Morse S, Ararat M, Graham FL. Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. FASEB J 2002; 16: 869-871.
19. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Biotechniques 1989; 7: 980-990. (Pubitemid 19262578)
20. Knouf EC, Metzger MJ, Mitchell PS, Arroyo JD, Chevillet JR, Tewari M et al. Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells. J Virol 2009; 83: 7353-7356.