Surgical treatment of gastrointestinal neuroendocrine tumors

Langenbeck's Archives of Surgery

Volumn 396, Issue 3, 2011, Pages 299-311

  Fendrich, Volker ^a   Bartsch, Detlef K ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Neuroendocrine gastrointestinal tumor; Neuroendocrine tumors of the ileum; Neuroendocrine tumors of the pancreas; Surgical therapy

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; KI 67 ANTIGEN; TUMOR MARKER;

ADVANCED CANCER; ARTIFICIAL EMBOLISM; CANCER PALLIATIVE THERAPY; CANCER SURVIVAL; CARCINOID SYNDROME; CLINICAL EFFECTIVENESS; CYTOREDUCTIVE SURGERY; GASTRINOMA; GASTROINTESTINAL TUMOR; HUMAN; ILEUM TUMOR; INSULINOMA; JEJUNUM TUMOR; LAPAROSCOPIC SURGERY; LIVER METASTASIS; LIVER RESECTION; LIVER TRANSPLANTATION; LOCAL METASTASIS; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MULTIPLE ENDOCRINE NEOPLASIA; NEUROENDOCRINE TUMOR; PANCREAS RESECTION; PANCREATICODUODENECTOMY; PATIENT SAFETY; PEROPERATIVE ECHOGRAPHY; PRIORITY JOURNAL; PROGNOSIS; RADIOFREQUENCY ABLATION; REVIEW; SPLENECTOMY; SURGICAL APPROACH; TUMOR DIFFERENTIATION; TUMOR VOLUME; ZOLLINGER ELLISON SYNDROME;

BIOPSY, NEEDLE; DIGESTIVE SYSTEM SURGICAL PROCEDURES; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEUROENDOCRINE TUMORS; PANCREATIC NEOPLASMS; PROGNOSIS; RISK ASSESSMENT; SURVIVAL ANALYSIS;

EID: 79955936551     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00423-011-0741-7     Document Type: Review

References (77)

1. Niederle MB, Hackl M, Kaserer K, Niederle B (2010) Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters. Endocr Relat Cancer 17:909-918
2. Klöppel G, Scherübl H (2010) Neuroendocrine tumors of the stomach. Risk stratification and therapy. Pathologe 31:182-187
3. Akerström G, Hellman P (2007) Surgery on neuroendocrine tumours. Best Pract Res Clin Endocrinol Metab 21:87-109 (Pubitemid 46421901)
4. Borch K, Ahrén B, Ahlman H et al (2005) Gastric carcinoids: biologic behavior and prognosis after differentiated treatment in relation to type. Ann Surg 242:64-73 (Pubitemid 40917969)
5. Ichikawa J, Tanabe S, Koizumi W et al (2003) Endoscopic mucosal resection in the management of gastric carcinoid tumors. Endoscopy 35:203-206 (Pubitemid 36292294)
6. Delle Fave G, Capurso G, Milione M, Panzuto F (2005) Endocrine tumours of the stomach. Best Pract Res Clin Gastroenterol 19:659-673 (Pubitemid 41614115)
7. Campana D, Nori F, Pezzilli R, Piscitelli L, Santini D, Brocchi E, Corinaldesi R, Tomassetti P (2008) Gastric endocrine tumors type I: treatment with long-acting somatostatin analogs. Endocr Relat Cancer 15:337-342 (Pubitemid 351449751)
8. Ruszniewski P, Delle Fave G, Cadiot G, Komminoth P, Chung D, Kos-Kudla B, Kianmanesh R, Hochhauser D, Arnold R, Ahlman H, Pauwels S, Kwekkeboom DJ, Rindi G, Frascati Consensus Conference Participants, European Neuroendocrine Tumor Society (2006) Well-differentiated gastric tumors/carcinomas. Neuroendocrinology 84:158-164 (Pubitemid 46361049)
9. Rindi G, Bordi C, Rappel S et al (1996) Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology, and behavior. World J Surg 20:168-172 (Pubitemid 26069482)
10. Metz DC, Jensen RT (2008) Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors. Gastroenterology 135:1469-1492
11. Öberg K, Eriksson B (2005) Endocrine tumors of the pancreas. Best Pract Res Clin Gastroenterol 19:753-781
12. Komminoth P, Perren A, Oberg K, Rindi G, Kloppel G, Heitz PU (2004) (2004) Gastrinoma. In: DeLellis RA, Lloyd R, Heitz PU, Eng C (eds) Pathology and genetics of tumors of the endocrine organs. WHO Classification of Tumors. IARC Press, Lyon, pp 191-194
13. Solcia E, Klöppel G, Sobin LH (2000) Histological typing of endocrine tumors. WHO International Histological Classification of Tumors, 2nd edn. Springer, Berlin, pp 56-70
14. Rindi G, Kloppel G, Alhman H, Caplin M, Couvelard A, de Herder WW, Erikssson B, Falchetti A, Falconi M, Komminoth P et al (2006) TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch 449:395-401 (Pubitemid 44451313)
15. Pape UF, Jann H, Müller-Nordhorn J, Bockelbrink A, Berndt U, Willich SN, Koch M, Röcken C, Rindi G, Wiedenmann B (2008) Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors. Cancer 113:256-265
16. de Herder WW, Niederle B, Scoazec JY, Pauwels S, Kloppel G, Falconi M, Kwekkeboom DJ, Oberg K, Eriksson B, Wiedenmann B, Rindi G, O'Toole D, Ferone D, Frascati Consensus Conference Participants, European Neuroendocrine Tumor Society (2006) Well-differentiated pancreatic tumor/carcinoma: insulinoma. Neuroendocrinology 84:183-188 (Pubitemid 46361052)
17. Danforth DNJ et al (1984) Metastatic insulin-secreting carcinoma of the pancreas: clinical course and the role of surgery. Surgery 96:1027-1036
18. Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V, Scarpa A, Sundin A, Perren A, Gross D, O'Connor JM, Pauwels S, Frascati Consensus Conference Participants, European Neuroendocrine Tumor Society (2006) Gastrinoma (duodenal and pancreatic). Neuroendocrinology 84:173-182 (Pubitemid 46361051)
19. Weber HC et al (1995) Determinants of metastatic rate and survival in patients with Zollinger-Ellison syndrome: a prospective long-term study. Gastroenterology 108:1637-1649
20. Yu F, Venzon DJ, Serrano J et al (1999) Prospective study of the clinical course, prognostic factors, causes of death, and survival in patients with long-standing Zollinger-Ellison syndrome. J Clin Oncol 17:615-630 (Pubitemid 29075250)
21. Hoffmann KM, Furukawa M, Jensen RT (2005) Duodenal neuroendocrine tumors: classification, functional syndromes, diagnosis and medical treatment. Best Pract Res Clin Gastroenterol 19:675-697 (Pubitemid 41614116)
22. O'Toole D, Salazar R, Falconi M, Kaltsas G, Couvelard A, de Herder WW, Hyrdel R, Nikou G, Krenning E, Vullierme MP, Caplin M, Jensen R, Eriksson B, Frascati Consensus Conference Participants, European Neuroendocrine Tumor Society (2006) Rare functioning pancreatic endocrine tumors. Neuroendocrinology 84:189-195 (Pubitemid 46361053)
23. Nilsson O, Van Cutsem E, Delle Fave G, Yao JC, Pavel ME, McNicol AM, Sevilla Garcia MI, Knapp WH, Keleştimur F, Sauvanet A, Pauwels S, Kwekkeboom DJ, Caplin M, Frascati Consensus Conference Participants, European Neuroendocrine Tumor Society (2006) Poorly differentiated carcinomas of the foregut (gastric, duodenal and pancreatic). Neuroendocrinology 84:212-215 (Pubitemid 46361055)
24. Fendrich V, Langer P, Celik I et al (2006) An aggressive surgical approach leads to long-term survival in patients with pancreatic endocrine tumors. Ann Surg 244:845-851, discussion 852-853
25. Bartsch DK, Fendrich V, Langer P et al (2005) Outcome of duodenopancreatic resections in patients with multiple endocrine neoplasia type 1. Ann Surg 242:757-764, discussion 764-766
26. Christ E, Wild D, Forrer F, Brändle M, Sahli R, Clerici T, Gloor B, Martius F, Maecke H, Reubi JC (2009) Glucagon-like peptide- 1 receptor imaging for localization of insulinomas. J Clin Endocrinol Metab 94:4398-4405
27. Fendrich V, Habbe N, Celik I et al (2007) Operative Therapie und Langzeitüberleben bei neuroendokrinen Pankreastumoren Erfahrungen bei 144 Patienten. Dtsch Med Wochenschr 2:195-200 (Pubitemid 46395765)
28. Rothmund M, Angelini L, Brunt M et al (1990) Surgery for benign insulinoma: an international review. World J Surg 14:393-399 (Pubitemid 20299939)
29. Hirshberg B et al (2002) Blind distal pancreatectomy for occult insulinoma, an inadvisable procedure. J Am Coll Surg 194:761-764 (Pubitemid 34633639)
30. Thompson NW (1998) Management of pancreatic endocrine tumors in patients with multiple endocrine neoplasia type 1. Surg Clin N Am 7:881-891
31. Norton JA, Fraker DL, Alexander HR et al (1999) Surgery to cure the Zollinger-Ellison syndrome. N Engl J Med 341:635-644
32. Norton JA, Jensen RT (2004) Resolved and unresolved controversies in the surgical management of patients with Zollinger-Ellison syndrome. Ann Surg 240:757-773
33. Norton JA, Fraker DL, Alexander HR et al (2006) Surgery increases survival in patients with gastrinoma. Ann Surg 244:410-419
34. Steinmüller T, Kianmanesh R, Falconi M, Scarpa A, Taal B, Kwekkeboom DJ, Lopes JM, Perren A, Nikou G, Yao J, Delle Fave GF, O'Toole D, Frascati Consensus Conference Participants (2008) Consensus guidelines for the management of patients with liver metastases from digestive (neuro)endocrine tumors: foregut, midgut, hindgut, and unknown primary. Neuroendocrinology 87:47-62 (Pubitemid 350308294)
35. Fendrich V, Langer P, Waldmann J et al (2007) The management of sporadic and MEN-1-gastrinomas. Br J Surg 94:1331-1341
36. Zogakis TG, Gibril F, Libutti SK et al (2003) Management and outcome of patients with sporadic gastrinoma arising in the duodenum. Ann Surg 238:42-48 (Pubitemid 38176406)
37. Mignon M, Ruszniewski P, Podevin P et al (1993) Current approach to the management of a gastrinoma and insulinoma in adults with multiple endocrine neoplasia I. World J Surg 17:489-495
38. Tonelli F, Fratini G, Nesi G et al (2006) Pancreatectomy in multiple endocrine neoplasia type 1-related gastrinomas and pancreatic endocrine neoplasias. Ann Surg 244:61-70 (Pubitemid 44297449)
39. Imamura M, Komoto I, Doi R et al (2005) New pancreas - preserving total duodenectomy technique.World J Surg 29:203-207
40. Hellman P, Andersson M, Rastad J et al (2000) Surgical strategy for large or malignant endocrine pancreatic tumors. World J Surg 24:1353-1360
41. Norton JA, Kivlen M, Li M et al (2003) Morbidity and mortality of aggressive resection in patients with advanced neuroendocrine tumors. Arch Surg 138:859-866
42. Fendrich V, Waldmann J, Bartsch DK et al (2009) Surgical management of pancreatic endocrine tumors. Nat Rev Clin Oncol 6:419-428
43. Kouvaraki MA, Solorzano CC, Shapiro SE et al (2005) Surgical treatment of non-functioning pancreatic islet cell tumors. J Surg Oncol 89:170-185 (Pubitemid 40315914)
44. Bartsch DK, Schilling T, Ramaswamy A et al (2000)Management of nonfunctioning islet cell carcinomas. World J Surg 24:1418-1424
45. Falconi M, Plockinger U, Kwekkeboom DJ, Manfredi R, Korner M, Kvols L, Pape UF, Ricke J, Goretzki PE, Wildi S, Steinmuller T, Oberg K, Scoazec JY, Frascati Consensus Conference Participants, European Neuroendocrine Tumor Society (2006) Welldifferentiated pancreatic nonfunctioning tumors/carcinoma. Neuroendocrinology 84:196-211
46. Solorzano CC, Lee JE, Pisters PTW et al (2001) Nonfunctioning islet cell carcinoma of the pancreas: Survival results in a contemporary series of 163 patients. Surgery 130:1078-1085 (Pubitemid 34014578)
47. Waldmann J, Fendrich V, Habbe N, Bartsch DK, Slater EP, Kann PH, Rothmund M, Langer P (2009) Screening of patients with multiple endocrine neoplasia type 1 (MEN-1): a critical analysis of its value. World J Surg 33:1208-1218
48. Skogseid B et al (1991) Multiple endocrine neoplasia type 1: a 10-year prospective screening study in four kindreds. J Clin Endocrinol Metab 73:281-287 (Pubitemid 21921870)
49. Plöckinger U, Rindi G, Arnold R, Eriksson B, Krenning EP, de Herder WW, Goede A, Caplin M, Oberg K, Reubi JC, Nilsson O, Delle Fave G, Ruszniewski P, Ahlman H, Wiedenmann B, European Neuroendocrine Tumour Society (2004) Guidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours. A consensus statement on behalf of the European Neuroendocrine Tumour Society (ENETS). Neuroendocrinology 80:394-424
50. Kann PH, Balakina E, Ivan D et al (2006) Natural course of small, asymptomatic neuroendocrine pancreatic tumours in multiple endocrine neoplasia type 1: an endoscopic ultrasound imaging study. Endocr Relat Cancer 13:1195-1202 (Pubitemid 46212573)
51. Thomas-Marques L, Murat A, Delemer B et al (2006) Prospective endoscopic ultrasonographic evaluation of the frequency of nonfunctioning pancreaticoduodenal endocrine tumors in patients with multiple endocrine neoplasia type 1. Am J Gastroenterol 101:266-273 (Pubitemid 43381666)
52. Triponez F, Goudet P, Dosseh D et al (2006) Is surgery beneficial for MEN1 patients with small (< or=2 cm), non-functioning pancreaticoduodenal endocrine tumor? An analysis of 65 patients from the GTE. World J Surg 30:654-662, discussion 663-664
53. Gagner M (1996) Early experience with laparoscopic resections of islet cell tumors. Surgery 120:1051-1054
54. Langer P, Bartsch DK, Fendrich V, Kann PH, Rothmund M, Zielke A (2005) Minimal-invasive operative treatment of organic hyperinsulinism. Dtsch Med Wochenschr 130:508-513
55. Fernandez-Cruz L, Cesar-Borges G (2006) Laparoscopic strategies for resection of insulinomas. J Gastrointest Surg 10:752-760
56. Carrere N et al (2007) Spleen-preserving distal pancreatectomy with excision of splenic artery and vein: a case-matched comparison with conventional distal pancreatectomy with splenectomy. World J Surg 31:375-382 (Pubitemid 46183526)
57. Akerström G, Hellman P, Hessman O (2005) Midgut carcinoid tumours: surgical treatment and prognosis. Best Pract Res Clin Gastroenterol 19:717-728 (Pubitemid 41614119)
58. Akerström G, Hellman P, Hessman O (2005) Management of midgut carcinoids. J Surg Oncol 89:161-169 (Pubitemid 40315913)
59. Habbe N, Fendrich V, Bartsch DK (2010) Solitary versus multiple carcinoid tumors of the ileum: a clinical analysis of 87 cases. Langenbecks Arch Surg 395:1179-1197
60. Gulec SA, Mountcastle TS, Frey D, Cundiff JD, Mathews E, Anthony L, O'Leary JP, Boudreaux JP (2002) Cytoreductive surgery in patients with advanced-stage carcinoid tumors. Am Surg 68:667-671, discussion 671-672 (Pubitemid 44971221)
61. Eriksson B, Klöppel G, Krenning E, Ahlman H, Plöckinger U, Wiedenmann B, Arnold R, Auernhammer C, Körner M, Rindi G, Frascati Consensus Conference Participants (2008) Consensus guidelines for the management of patients with digestive neuroendocrine tumors - well-differentiated jejunal-ileal tumor/carcinoma. Neuroendocrinology 87:8-19 (Pubitemid 350308290)
62. Arnold R, Rinke A, Klose KJ et al (2005) Octreotide versus octreotide plus interferon-α in endocrine gastroenteropancreatic tumors: a randomized trial. Clin Gastroenterol Hepatol 3:761-771 (Pubitemid 41116728)
63. Ohrvall U, Eriksson B, Juhlin C, Karacagil S, Rastad J, Hellman P, Akerström G (2000) Method for dissection of mesenteric metastases in mid-gut carcinoid tumors. World J Surg 24:1402-1408
64. Rinke A, Müller HH, Schade-Brittinger C, Klose KJ, Barth P, Wied M, Mayer C, Aminossadati B, Pape UF, Bläker M, Harder J, Arnold C, Gress T, PROMID Study Group (2009) Placebocontrolled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol 27:4656-4663
65. Makridis C, Rastad J, Oberg K, Akerström G (1996) Progression of metastases and symptom improvement from laparotomy in midgut carcinoid tumors. World J Surg 20:900-906, discussion 907
66. Sarmiento JM et al (2003) Surgical treatment of neuroendocrine metastases to the liver: a plea for resection to increase survival. J Am Coll Surg 197:29-37 (Pubitemid 36759176)
67. Touzios JG, Kiely JM, Pitt SC, Rilling WS, Quebbeman EJ, Wilson SD et al (2005) Neuroendocrine hepatic metastases: does aggressive management improve survival? Ann Surg 241:776-785
68. Dousset B, Saint-Marc O, Pitre J et al (1996) Metastatic endocrine tumors: medical treatment, surgical resection, or liver transplantation. World J Surg 20:908-914
69. Que FG, Nagorny DM, Batts KP et al (1995) Hepatic resection for metastatic neuroendocrine carcinomas. Am J Surg 169:36-42
70. Chen H, Hardacre JM, Uzar A, Cameron JL, Choti MA (1998) Isolated liver metastases from neuroendocrine tumors: does resection prolong survival? J Am Coll Surg 187:88-192
71. Chamberlain RS, Canes D, Brown KT et al (2000) Hepatic neuroendocrine metastases: does intervention alter outcomes? J Am Coll Surg 190:432-435
72. Nave H, Mossinger E, Feist H et al (2001) Surgery as primary treatment in patients with liver metastases from carcinoid tumors: a retrospective, unicentric study over 13 years. Surgery 129:170-175
73. Kianmanesh R, Sauvanet A, Hentic O, Couvelard A, Lévy P, Vilgrain V, Ruszniewski P, Belghiti J (2008) Two-step surgery for synchronous bilobar liver metastases from digestive endocrine tumors: a safe approach for radical resection. Ann Surg 247:659-665 (Pubitemid 351440617)
74. Modlin IM, Lye KD, Kidd M (2003) A 5-decade analysis of 13, 715 carcinoid tumours. Cancer 97:934-959 (Pubitemid 36173145)
75. Vogl TJ, Naguib NN, Zangos S, Eichler K, Hedayati A, Nour-Eldin NE (2009) Liver metastases of neuroendocrine carcinomas: interventional treatment via transarterial embolization, chemoembolization and thermal ablation. Eur J Radiol 72:517-528
76. Pascher A, Klupp J, Neuhaus P (2005) Transplantation in the management of metastatic endocrine tumours. Best Pract Res Clin Gastroenterol 19:637-648 (Pubitemid 41447723)
77. Rosenau J, Bahr MJ, von Wasielewski R, Mengel M, Schmidt HH, Nashan B, Lang H, Klempnauer J, Manns MP, Boeker KH (2002) Ki67, E-cadherin, and p53 as prognostic indicators of long-term outcome after liver transplantation for metastatic neuroendocrine tumours. Transplantation 73:386-394