Lactoferrin inhibits the inflammatory and angiogenic activation of bovine aortic endothelial cells

Inflammation Research

Volumn 60, Issue 5, 2011, Pages 475-482

  Yeom, Mijung ^a   Park, Jongbong ^a   Lee, Bombi ^a   Choi, Sang Yun ^b   Kim, Kyoung Soo ^c   Lee, Hyejung ^a   Hahm, Dae Hyun ^a  

^a Kyung Hee University   (South Korea)

^b Korea University   (South Korea)

^c Kyung Hee University College of Medicine   (South Korea)

Author keywords

Angiogenesis in vitro; Bovine aortic endothelial cells (BAEC); Endothelium; Lactoferrin

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTOFERRIN; MESSENGER RNA;

ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; COW; DRUG MECHANISM; ENDOTHELIUM CELL; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; AORTA; CATTLE; CELL ADHESION; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; INFLAMMATION; LACTOFERRIN; LEUKOCYTES; MONOCYTES; NEOVASCULARIZATION, PATHOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 79955934355     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-010-0294-1     Document Type: Article

References (46)

1. Sanchez L, Calvo M, Brock JH. Biological role of lactoferrin. Arch Dis Child. 1992;67:657-61.
2. Masson PL, Heremans JF, Schonne E. Lactoferrin, an iron-binding protein in neutrophilic leukocytes. J Exp Med. 1969;130:643-58.
3. Arnold RR, Cole MF, McGhee JR. A bactericidal effect for human lactoferrin. Science. 1977;197:263-5. (Pubitemid 8130437)
4. Legrand D, Mazurier J. A critical review of the roles of host lactoferrin in immunity. Biometals. 2010;23:365-76.
5. Ward PP, Conneely OM. Lactoferrin: role in iron homeostasis and host defense against microbial infection. Biometals. 2004;17:203-8. (Pubitemid 38987138)
6. Caccavo D, Garzia P, Sebastiani GD, Ferri GM, Galluzzo S, Vadacca M, et al. Expression of lactoferrin on neutrophil granulocytes from synovial fluid and peripheral blood of patients with rheumatoid arthritis. J Rheumatol. 2003;30:220-4. (Pubitemid 36152580)
7. Hayashida K, Kaneko T, Takeuchi T, Shimizu H, Ando K, Harada E. Oral administration of lactoferrin inhibits inflammation and nociception in rat adjuvant-induced arthritis. J Vet Med Sci. 2004;66:149-54. (Pubitemid 41380329)
8. Mohan KV, Gunasekaran P, Varalakshmi E, Hara Y, Nagini S. In vitro evaluation of the anticancer effect of lactoferrin and tea polyphenol combination on oral carcinoma cells. Cell Biol Int. 2007;31:599-608.
9. Wolf JS, Li G, Varadhachary A, Petrak K, Schneyer M, Li D, et al. Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivo. Clin Cancer Res. 2007;13:1601-10. (Pubitemid 46450453)
10. Choe YH, Lee SW. Effect of lactoferrin on the production of tumor necrosis factor-alpha and nitric oxide. J Cell Biochem. 1999;76:30-6.
11. Shinoda I, Takase M, Fukuwatari Y, Shimamura S, Koller M, Konig W. Effects of lactoferrin and lactoferricin on the release of interleukin 8 from human polymorphonuclear leukocytes. Biosci Biotechnol Biochem. 1996;60:521-3. (Pubitemid 126460945)
12. Sorimachi K, Akimoto K, Hattori Y, Ieiri T, Niwa A. Activation of macrophages by lactoferrin: secretion of TNF-alpha, IL-8 and NO. Biochem Mol Biol Int. 1997;43:79-87.
13. Zucali JR, Broxmeyer HE, Levy D, Morse C. Lactoferrin decreases monocyte-induced fibroblast production of myeloid colony-stimulating activity by suppressing monocyte release of interleukin-1. Blood. 1989;74:1531-6. (Pubitemid 19251525)
14. Yoo YC, Watanabe S, Watanabe R, Hata K, Shimazaki K, Azuma I. Bovine lactoferrin and lactoferricin, a peptide derived from bovine lactoferrin, inhibit tumor metastasis in mice. Jpn J Cancer Res. 1997;88:184-90. (Pubitemid 27129646)
15. Folkman J, Shing Y. Angiogenesis. J Biol Chem. 1992;267:10931-4.
16. Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671-4. (Pubitemid 27193480)
17. Rajashekhar G, Willuweit A, Patterson CE, Sun P, Hilbig A, Breier G, et al. Continuous endothelial cell activation increases angiogenesis: evidence for the direct role of endothelium linking angiogenesis and inflammation. J Vasc Res. 2006;43:193-204. (Pubitemid 43248001)
18. Tian Y, Jain S, Kelemen SE, Autieri MV. AIF-1 expression regulates endothelial cell activation, signal transduction, and vasculogenesis. Am J Physiol Cell Physiol. 2009;296:C256-66.
19. Auerbach R, Lewis R, Shinners B, Kubai L, Akhtar N. Angiogenesis assays: a critical overview. Clin Chem. 2003;49:32-40. (Pubitemid 36078551)
20. Osborn L. Leukocyte adhesion to endothelium in inflammation. Cell. 1990;62:3-6.
21. Staton CA, Reed MW, Brown NJ. A critical analysis of current in vitro and in vivo angiogenesis assays. Int J Exp Pathol. 2009;90:195-221.
22. Dogru M, Matsumoto Y, Yamamoto Y, Goto E, Saiki M, Shimazaki J, et al. Lactoferrin in Sjogren's syndrome. Ophthalmology. 2007;114:2366-7.
23. Folkman J, Klagsbrun M. Angiogenic factors. Science. 1987;235:442-7. (Pubitemid 17009577)
24. Kaiser M, Younge B, Bjornsson J, Goronzy JJ, Weyand CM. Formation of new vasa vasorum in vasculitis. Production of angiogenic cytokines by multinucleated giant cells. Am J Pathol. 1999;155:765-74. (Pubitemid 29426822)
25. Ross R. Atherosclerosis is an inflammatory disease. Am Heart J. 1999;138:S419-20.
26. Schoettler N, Brahn E. Angiogenesis inhibitors for the treatment of chronic autoimmune inflammatory arthritis. Curr Opin Investig Drugs. 2009;10:425-33.
27. Pohlman TH, Stanness KA, Beatty PG, Ochs HD, Harlan JM. An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism. J Immunol. 1986;136:4548-53. (Pubitemid 16090675)
28. Evans SS, Fisher DT, Skitzki JJ, Chen Q. Targeted regulation of a lymphocyte-endothelial-interleukin-6 axis by thermal stress. Int J Hyperthermia. 2008;24:67-78. (Pubitemid 351167620)
29. Okawa-Takatsuji M, Aotsuka S, Fujinami M, Uwatoko S, Kinoshita M, Sumiya M. Up-regulation of intercellular adhesion molecule-1 (ICAM-1), endothelial leucocyte adhesion molecule- 1 (ELAM-1) and class II MHC molecules on pulmonary artery endothelial cells by antibodies against U1-ribonucleoprotein. Clin Exp Immunol. 1999;116:174-80. (Pubitemid 29170022)
30. Kevil CG, Orr AW, Langston W, Mickett K, Murphy-Ullrich J, Patel RP, et al. Intercellular adhesion molecule-1 (ICAM-1) regulates endothelial cell motility through a nitric oxide-dependent pathway. J Biol Chem. 2004;279:19230-8. (Pubitemid 38623354)
31. Moser R, Schleiffenbaum B, Groscurth P, Fehr J. Interleukin 1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage. J Clin Invest. 1989;83:444-55. (Pubitemid 19061163)
32. Shreeniwas R, Koga S, Karakurum M, Pinsky D, Kaiser E, Brett J, et al. Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface. J Clin Invest. 1992;90:2333-9. (Pubitemid 23010050)
33. Hellwig-Burgel T, Rutkowski K, Metzen E, Fandrey J, Jelkmann W. Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood. 1999;94:1561-7. (Pubitemid 29411306)
34. Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 2003;17:2115-7.
35. Libermann TA, Baltimore D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol. 1990;10:2327-34.
36. Majno G. Chronic inflammation: links with angiogenesis and wound healing. Am J Pathol. 1998;153:1035-9. (Pubitemid 28465827)
37. Freiburghaus C, Janicke B, Lindmark-Mansson H, Oredsson SM, Paulsson MA. Lactoferricin treatment decreases the rate of cell proliferation of a human colon cancer cell line. J Dairy Sci. 2009;92:2477-84.
38. Zemann N, Klein P, Wetzel E, Huettinger F, Huettinger M. Lactoferrin induces growth arrest and nuclear accumulation of Smad-2 in HeLa cells. Biochimie. 2010;92:880-4.
39. Lee SH, Hwang HM, Pyo CW, Hahm DH, Choi SY. E2F1-directed activation of Bcl-2 is correlated with lactoferrin-induced apoptosis in Jurkat leukemia T lymphocytes. Biometals. 2010;23:507-14.
40. Xu XX, Jiang HR, Li HB, Zhang TN, Zhou Q, Liu N. Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin. J Dairy Sci. 2010;93:2344-50.
41. Cornish J. Lactoferrin promotes bone growth. Biometals. 2004;17:331-5. (Pubitemid 38987158)
42. Norrby K, Mattsby-Baltzer I, Innocenti M, Tuneberg S. Orally administered bovine lactoferrin systemically inhibits VEGF (165)-mediated angiogenesis in the rat. Int J Cancer. 2001;91:236-40.
43. Shimamura M, Yamamoto Y, Ashino H, Oikawa T, Hazato T, Tsuda H, et al. Bovine lactoferrin inhibits tumor-induced angiogenesis. Int J Cancer. 2004;111:111-6. (Pubitemid 38859291)
44. Kim CW, Son KN, Choi SY, Kim J. Human lactoferrin upregulates expression of KDR/Flk-1 and stimulates VEGF-A-mediated endothelial cell proliferation and migration. FEBS Lett. 2006;580:4332-6. (Pubitemid 44118249)
45. Ward PP, Mendoza-Meneses M, Mulac-Jericevic B, Cunningham GA, Saucedo-Cardenas O, Teng CT, et al. Restricted spatiotemporal expression of lactoferrin during murine embryonic development. Endocrinology. 1999;140:1852-60. (Pubitemid 29149258)
46. Teng CT. Lactoferrin: the path from protein to gene. Biometals. 2010;23:359-64.