Design and synthesis of O-GlcNAcase inhibitors via 'click chemistry' and biological evaluations

Carbohydrate Research

Volumn 346, Issue 9, 2011, Pages 1083-1092

  Li, Tiehai ^a   Guo, Lina ^a   Zhang, Yan ^a   Wang, Jiajia ^a   Li, Zhonghua ^a   Lin, Lin ^a   Zhang, Zhenxing ^a   Li, Lei ^a   Lin, Jianping ^a   Zhao, Wei ^a   Li, Jing ^a   Wang, Peng George ^a,b  

^a NANKAI UNIVERSITY   (China)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

'Click chemistry'; Inhibitor; O GlcNAcase

Indexed keywords

BIOLOGICAL EVALUATION; BIOLOGICAL PROCESS; CELL CYCLE; CELLULAR PROCESS; CLICK CHEMISTRY; CLOSTRIDIUM PERFRINGENS; CYCLOADDITION REACTION; DNA TRANSCRIPTIONS; ENZYMATIC KINETIC; GLYCOSYL AZIDES; INHIBITOR; INHIBITORY ACTIVITY; MOLECULAR DOCKING SIMULATIONS; N-ACETYLGLUCOSAMINE; O-GLCNACASE; O-LINKED; PROTEIN DEGRADATION; STACKING INTERACTION; THREONINE RESIDUES;

ACETYLENE; AMINO ACIDS; CYCLOADDITION; NEURODEGENERATIVE DISEASES; SIGNAL TRANSDUCTION;

BIOSYNTHESIS;

1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL 4 [2 (1H PYRAZOL 1 YL) 6 PYRIDYL] 1,2,3 TRIAZOLE; 1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) 4 (2 PYRIMIDYL) 1,2,3 TRIAZOLE; 1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) 4 (4 PYRAZOLYL) 1,2,3 TRIAZOLE; 1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) 4 (5 URACILYL) 1,2,3 TRIAZOLE; 1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) 4 (PHENYLCARBAMOYL) 1,2,3 TRIAZOLE; 1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) 4 [(E) 3 (4 METHOXYBENZYLOXYAMINO) 3 OXOPROP 1 ENYL] 1,2,3 TRIAZOLE; 1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) 4 [3 N (1,3 DIOXO 1H BENZO [DE] ISOQUINOLIN 2(3H) YL) PHENYL] 1,2,3 TRIAZOLE; 1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) 4 HYDROXYMETHYL 1,2,3 TRIAZOLE; 1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) 4 PENTYL 1,2,3 TRIAZOLE; 1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) 4 PHENYL 1,2,3 TRIAZOLE; 1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) 4 PYRIDYL 1,2,3 TRIAZOLE; 2 (1H PYRAZOL 1 YL) 6 [(TRIMETHYLSILYL) ETHYNYL] PYRIDINE; 2 [(TRIMETHYLSILYL) ETHYNYL] PYRAZINE; 2 [(TRIMETHYLSILYL) ETHYNYL] PYRIMIDINE; 2 [(TRIMETHYLSILYL) ETHYNYL] THIAZOLE; 3 [(TRIMETHYLSILYL) ETHYNYL] 7 AZAINDOLE; 3 [(TRIMETHYLSILYL) ETHYNYL] QUINOLINE; 3',5' DI O ACETYL 2' DEOXY 5 [(TRIMETHYLSILYL) ETHYNYL] URIDINE; 4 [(TRIMETHYLSILYL) ETHYNYL] PYRAZOLE; 4 [3 (7 AZAINDOLYL)] 1 (2' ACETAMIDO 3',4',6' TRI O ACETYL 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) 1,2,3 TRIAZOLE; 5 [(TRIMETHYLSILYL) ETHYNYL] URACIL; ALKYNE; AZIDE; COPPER; ENZYME INHIBITOR; GLYCOSYL AZIDE DERIVATIVE; N ACETYL BETA GLUCOSAMINIDASE; N ACETYL BETA GLUCOSAMINIDASE INHIBITOR; N ACETYLGLUCOSAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CLICK CHEMISTRY; CLOSTRIDIUM PERFRINGENS; CYCLOADDITION; DRUG SYNTHESIS; ENZYME KINETICS; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION;

CLICK CHEMISTRY; CLOSTRIDIUM PERFRINGENS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; N-ACETYLGLUCOSAMINYLTRANSFERASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

CLOSTRIDIUM PERFRINGENS;

EID: 79955932260     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2011.03.026     Document Type: Article

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