Evaluation of the anti-inflammatory and analgesic effects of piroxicamloaded microemulsion in topical formulations

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 3, Issue 2, 2011, Pages 66-70

  Abd Allah, Fathy I ^a   Dawaba, Hamdy M ^a   Mansour, Ahmed ^a   Samy, Ahmed M ^a  

^a Al Azhar University   (Egypt)

Author keywords

Analgesic effect; Anti inflammatory effect; Formulations; Microemulsion; Piroxicam; Topical

Indexed keywords

CARRAGEENAN; PIROXICAM;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG SCREENING; HOT PLATE TEST; MALE; MICROEMULSION; NONHUMAN; PAW EDEMA; RAT; REACTION TIME; TREATMENT OUTCOME;

EID: 79955930116     PISSN: 09751491     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Hedner T, Samulesson O, Wahrborg P, Wadenvik H, Ung KA and Ekbom A. Nabumetone: Therapeutic Use and Safety Profile in the Management of Osteoarthritis's and Rheumatoid Arthritis Drugs. 2004; 64(20): 2315-43.
2. Izdes S, Orhun S, Turanii S, Erkilic E and Kanbak, O. The effects of preoperative inflammation on the analgesic efficacy of intraarticular piroxicam for outpatient knee arthroscopy, Anesth. Analg. 2003; 97 (4): 1016-19.
3. Analytical Profiles of Drug Substances and Excipients, Hary G. Brittain (ed.), Academic press, 1999; 15: p. 509.
4. Martindale: The Complete Drug Reference, Sweetman, S.C., (ed.), London, the Pharmaceutical Press, Electronic version., 2005.
5. Hardman JG; Limbird LE, Molinoff PB, Ruddon RW and Gilman AG. Drugs acting on the central nervous system and Autacoids; drug therapy of inflammation. In: The Pharmacological Basis of Therapeutics. 9ed, section III AND IV. Goodman and Gilman's (eds). New York: McGraw-Hill: 1996, p. 265-682.
6. Levine JD, Coderre, TJ and Basbaum AI. The peripheral nervous system and the inflammatory process. In Dubner, R.; Gebhart, G. F. and Bond, M. R. (eds): Proceedings of the Vth world congress on pain. Amesterdam Elsevier Science Publishers. 1988; 33-43.
7. McHugh JM and McHugh WB: Pain: neuroanatomy, chemical mediators, and clinical implications. AACN Clin Issues, 2000, 11: 168-78.
8. Berne RM, Winn HR, and Rubio R: The local regulation of cerebral blood flow. Prog. Cardiovasc. Dis. 1981; 24: 243-60.
9. Steen KH, Reeh PW, Anton F and Handwerker HO. Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro. J Neurosci. 1992; 12: 86-95.
10. Abd-Allah FI, Dawaba HM and Ahmed AMS. Preparation, characterization, and stability studies of piroxicam-loaded microemulsions in topical formulations. Drug Discov Ther. 2010; 4 (4): 267-75.
11. Badran M, Ahmed AMS, Ibrahim E. Pharmaceutical studies on percutaneous drug delivery of certain medicaments (M. Sc. Thesis). Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt, 2004.
12. Tarek AA, Hany MI, Fathy IA, Ahmed MS, Ehab F and Mohammad TH. In vitro release, rheological, and stability studies of mefenamic acid coprecipitates in topical formulations. Pharmaceutical Development and Technology, 2010; 1-14, Early Online.
13. USP 24/NF 19. Dissolution Apparatus Description. Prepared by the Committee of Revision and Published by the Board of Trustees, 1995; pp. 1791-93.
14. Dalmora ME, Dalmora SL, Oliveria AG. Inclusion complex of piroxicam with β-cyclodextrin and incorporation in cationic microemulsion, In vitro drug release and In vivo topical antiinflammatory effect. Int J Pharm. 2001; 222: 45-55.
15. Puri RD and Sanghavi NM. Evaluation of Topical Non-Steroidal Drugs of Using Penetration Enhancers. Indian Journal of Pharmacology, 1992; 24(4): 227-28.
16. Reddy DN, and Udupa N. Formulation and Evaluation of Oral and Transdermal Preparations of Flurbiprofen and Piroxicam Incorporated with Different Carries. Drug Dev. Ind. Pharm. 1993; 19(7): 843-53.
17. Shahiwala A, and Misra A. Studies in Topical Application of Niosomally Entrapped Nimesulide. J. Pharm. Pharmaceut. Sci., 2002; 5(3): 220-25.
18. Boughton-Smith NK, Deakin AM, Follenfant RL, Whittle BJ, and Garland LG. Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat. Br. J Pharmacol. 1993; 110: 896-902.
19. Gupta M, Mazumder UK, Kumar RS and Kumar TS. "Studies on Anti-Inflammatory, Analgesic and Antipyretic Properties of Methanol Extract of Caesalpinia bonducella leaves in Experimental Animal Models". Iranian. J. Pharm. Therap. 2003; 2: 30-34.