Treatment of spinal cord injury with bone marrow-derived, cultured autologous mesenchymal stem cells

Tissue Engineering and Regenerative Medicine

Volumn 7, Issue 3, 2010, Pages 316-322

  Jeon, Sang Ryong ^a   Park, Jin Hoon ^a   Lee, Jung Hwan ^a   Kim, Dae Yul ^a   Kim, Hyun Soo ^b   Sung, Inn Young ^a   Choi, Gyong Hyo ^a   Jeon, Min Ho ^a   Kim, Guang Gook ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Yonsei University Wonju College of Medicine   (South Korea)

Author keywords

Adult stem cell; Electrophysiological change; Evoked potential; Mesenchymal stem cell; Spinal cord injury

Indexed keywords

ADULT STEM CELLS; CLINICAL PILOT STUDY; ELECTROPHYSIOLOGICAL CHANGE; ELECTROPHYSIOLOGICAL STUDIES; MESENCHYMAL STEM CELL; MOTOR EVOKED POTENTIALS; SOMATOSENSORY EVOKED POTENTIALS; SPINAL CORD INJURIES (SCI);

BIOELECTRIC POTENTIALS; DOSIMETRY; ELECTROMYOGRAPHY; ELECTROPHYSIOLOGY; FLOWCHARTING; MAGNETIC RESONANCE IMAGING; NEUROLOGY; PATIENT MONITORING; PATIENT REHABILITATION; PATIENT TREATMENT; STEM CELLS;

CELL CULTURE;

EID: 79955929995     PISSN: 17382696     EISSN: 22125469     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Y Nishio, M Koda, T Kamada, et al., The use of hemopoietic stem cells derived from human umbilical cord blood to promote restoration of spinal cord tissue and recovery of hindlimb function in adult rats, J Neurosurg Spine, 5, 424 (2006).
2. L Mazzini, F Fagioli, R Boccaletti, et al., Stem cell therapy in amyotrophic lateral sclerosis: a methodological approach in humans, Amyotroph Lateral Scler Other Motor Neuron Disord, 4, 158 (2003).
3. CG Janson, TM Ramesh, MJ During, et al., Human intrathecal transplantation of peripheral blood stem cells in amyotrophic lateral sclerosis, J Hematother Stem Cell Res, 10, 913 (2001).
4. PH Lee, JW Kim, OY Bang, et al., Autologous mesenchymal stem cell therapy delays the progression of neurological deficits in patients with multiple system atrophy, Clin Pharmacol Ther, 83, 723 (2008).
5. CR Freed, PE Greene, RE Breeze, et al., Transplantation of embryonic dopamine neurons for severe Parkinson's disease, N Engl J Med, 344, 710 (2001).
6. I Date, T Yasuhara, Neurological disorders and neural regeneration, with special reference to Parkinson's disease and cerebral ischemia, J Artif Organs, 12, 11 (2009).
7. HC Park, YS Shim, HA Yoon, et al., Treatment of Complete Spinal Cord Injury Patients by Autologous Bone Marrow Cell Transplantation and Administration of Granulocyte-Macrophage Colony Stimulation Factor, Tissue engineering, 11, 913 (2005).
8. M Chopp, XH Zhang, Y Li, et al., Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation, Neuroreport, 11, 3001 (2000).
9. KK Jain, Cell therapy for CNS trauma, Mol Biotechnol, 42, 367 (2009).
10. OY Bang, JS Lee, PH Lee, et al., Autologous mesenchymal stem cell transplantation in stroke patients, Ann Neurol, 57, 874 (2005).
11. Y Ha, SH Yoon, SR Park, et al., Treatment of Complete Spinal Cord Injury Patients Receiving Autologous Bone Marrow Cell Transplantation and Bone Marrow Stimulation with Granulocyte Macrophage-Colony Stimulating Factor: Report of Three Cases, J Korean Neurosurg Soc, 35(5), 459 (2004).
12. N Knoller, G Auerbach, V Fulga, et al., Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: phase I study results, J Neurosurg Spine, 3(3), 173 (2005).
13. SS Rabinovich, VI Seledtsov, NV Banul, et al., Cell therapy of brain stroke, Cell Technologies in Biology and Medicine, 1(1), 126 (2005).
14. A Bakshi, C Hunter, S Swanger, et al., Minimally invasive delivery of stem cells for spinal cord injury: advantages of the lumbar puncture technique, J Neurosur Spine, 1(3), 330 (2004).
15. AC Lepore, A Bakshi, SA Swanger, et al., Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord, Brain Res, 31, 1045, (1- 2), 206 (2005).
16. JW Fawcett, A Curt, JD Steeves, et al., Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials, Spinal Cord, 45, 190 (2007).
17. A Curt, HJA van Hedel, D Klaus, et al., Recovery from a spinal cord injury:significance of compensation, neural plasticity, and repair. J Neurotrauma, 25, 677 (2008).
18. M Spiess, M Schubert, U Kliesch, et al., Evolution of tibial SSEP after traumatic spinal cord injury: baseline for clinical trials, Clin Neurophysiol, 119, 1051 (2008).
19. F Callera, Delivery of autologous bone marrow precursor cells into spinal cord via lumbar puncture technique in patients with spinal cord injury: A preliminary safety study, Experimental Hematology, 34, 130 (2006).
20. F Saito, T Nakatani, M Iwase, et al., Spinal cord injury treatment with intrathecal autologous bone marrow stromal cell transplantation: the first clinical trial case report, J Trauma, 64(1):53, (2008).
21. R Pal, NK Venkataramana, A Bansal, et al., Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study, Cytotherapy, 11(7), 897 (2009).