Focal nodular hyperplasia or focal nodular hyperplasia-like lesions of the liver: A special emphasis on diagnosis

Journal of Gastroenterology and Hepatology (Australia)

Volumn 26, Issue 6, 2011, Pages 1004-1009

  Choi, Ji Young ^a   Lee, Han Chu ^a   Yim, Ji Hye ^a   Shim, Ju Hyun ^a   Lim, Young Suk ^a   Shin, Yong Moon ^a   Yu, Eun Sil ^a   Suh, Dong Jin ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Diagnosis; Focal nodular hyperplasia; Hepatocellular carcinoma

Indexed keywords

HEPATITIS B SURFACE ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; BUDD CHIARI SYNDROME; CHILD; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC ERROR; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; NEEDLE BIOPSY; NODULAR HYPERPLASIA; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

EID: 79955916653     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2011.06659.x     Document Type: Article

References (27)

1. International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995; 22: 983-93.
2. Motosugi U, Murata S, Shimizu M etal. Extranodular background liver parenchyma of focal nodular hyperplasia: histopathological characteristics. Virchows Arch. 2009; 454: 557-62.
3. Takahashi S, Miyanishi K, Takada K etal. Case report of a focal nodular hyperplasia-like nodule present in cirrhotic liver. Hepatol. Res. 2008; 38: 521-8.
4. Kondo F. Focal nodular hyperplasia-like lesions in heavy drinkers. Intern. Med. 2009; 48: 1117-23.
5. Lee YH, Kim SH, Cho MY, Shim KY, Kim MS. Focal nodular hyperplasia-like nodules in alcoholic liver cirrhosis: radiologic-pathologic correlation. AJR Am. J. Roentgenol. 2007; 188: W459-63.
6. Libbrecht L, Cassiman D, Verslype C etal. Clinicopathological features of focal nodular hyperplasia-like nodules in 130 cirrhotic explant livers. Am. J. Gastroenterol. 2006; 101: 2341-6.
7. Nakashima O, Kurogi M, Yamaguchi R etal. Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules? J. Hepatol. 2004; 41: 992-98.
8. Bruix J, Sherman M. 2010. Management of Hepatocellular Carcinoma: An update. Cited 28 Dec 2010. Available from URL:
9. Therasse P, Arbuck SG, Eisenhauer EA etal. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J. Natl. Cancer Inst. 2000; 92: 205-16.
10. Di Carlo I, Urrico GS, Ursino V, Russello D, Puleo S, Latteri F. Simultaneous occurrence of adenoma, focal nodular hyperplasia, and hemangioma of the liver: are they derived from a common origin? J. Gastroenterol. Hepatol. 2003; 18: 227-30.
11. Terada T, Kitani S, Ueda K, Nakanuma Y, Kitagawa K, Masuda S. Adenomatous hyperplasia of the liver resembling focal nodular hyperplasia in patients with chronic liver disease. Virchows Arch. A Pathol. Anat. Histopathol. 1993; 422: 247-52.
12. Wersebe A, Wiskirchen J, Decker U etal. Comparison of Gadolinium-BOPTA and Ferucarbotran-enhanced three-dimensional T1-weighted dynamic liver magnetic resonance imaging in the same patient. Invest. Radiol. 2006; 41: 264-71.
13. Shen YH, Fan J, Wu ZQ etal. Focal nodular hyperplasia of the liver in 86 patients. Hepatobiliary Pancreat. Dis. Int. 2007; 6: 52-7.
14. Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology 2005; 42: 1208-36.
15. Petsas T, Tsamandas A, Tsota I etal. A case of hepatocellular carcinoma arising within large focal nodular hyperplasia with review of the literature. World J. Gastroenterol. 2006; 12: 6567-71.
16. Ahn SS, Kim MJ, Lim JS, Hong HS, Chung YE, Choi JY. Added value of gadoxetic acid-enhanced hepatobiliary phase MR imaging in the diagnosis of hepatocellular carcinoma. Radiology 2010; 255: 459-66.
17. Grazioli L, Morana G, Kirchin MA etal. MRI of focal nodular hyperplasia (FNH) with gadobenate dimeglumine (Gd-BOPTA) and SPIO (ferumoxides): an intra-individual comparison. J. Magn. Reson. Imaging 2003; 17: 593-602.
18. Nguyen BN, Flejou JF, Terris B, Belghiti J, Degott C. Focal nodular hyperplasia of the liver: a comprehensive pathologic study of 305 lesions and recognition of new histologic forms. Am. J. Surg. Pathol. 1999; 23: 1441-54.
19. Lee IJ, Jeong SH, Choi JW, Park HS, Lee KH, Kim H. Radiological findings in a case of multiple focal nodular hyperplasia associated with portal vein atresia and portopulmonary hypertension. Korean J. Radiol. 2008; 9: 386-9.
20. Kang HY, La SS, Kong JH etal. [Clinical, radiological and pathological exploration of focal nodular hyperplasia of liver reported in Korea]. Korean J. Gastroenterol. 2008; 52: 376-83.
21. Choi CS, Freeny PC. Triphasic helical CT of hepatic focal nodular hyperplasia: incidence of atypical findings. AJR Am. J. Roentgenol. 1998; 170: 391-5.
22. Brancatelli G, Federle MP, Grazioli L, Blachar A, Peterson MS, Thaete L. Focal nodular hyperplasia: CT findings with emphasis on multiphasic helical CT in 78 patients. Radiology 2001; 219: 61-8.
23. Sherman M. The radiological diagnosis of hepatocellular carcinoma. Am. J. Gastroenterol. 2010; 105: 610-2.
24. Fukukura Y, Nakashima O, Kusaba A, Kage M, Kojiro M. Angioarchitecture and blood circulation in focal nodular hyperplasia of the liver. J. Hepatol. 1998; 29: 470-75.
25. Grazioli L, Morana G, Federle MP etal. Focal nodular hyperplasia: morphologic and functional information from MR imaging with gadobenate dimeglumine. Radiology 2001; 221: 731-9.
26. Marrero JA. Modern diagnosis of hepatocellular carcinoma: utilization of liver biopsy and genomic markers. J. Hepatol. 2009; 50: 659-61.
27. Di Tommaso L, Destro A, Seok JY etal. The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma. J. Hepatol. 2009; 50: 746-54.