Prospective operationalization and feasibility of a glycemic control protocol in critically ill children

Pediatric Critical Care Medicine

Volumn 12, Issue 3, 2011, Pages 265-270

  Branco, Ricardo Garcia ^b,c   Xavier, Lisandra ^a   Ramos Garcia, Pedro Celiny ^b,c   Piva, Jefferson Pedro ^b,c   Fiori, Humberto Holmer ^b,c   Baldisserotto, Matteo ^b,c   Fiori, Renato MacHado ^b,c   Tasker, Robert Charles ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Hospital São   (Brazil)

^c PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

children; glycemic control; hyperglycemia; insulin; pediatric intensive care

Indexed keywords

GLUCOSE; HYDROCORTISONE; INSULIN; VASOACTIVE AGENT;

ARTICLE; ARTIFICIAL VENTILATION; BLOOD GLUCOSE MONITORING; BRAZIL; CHILD; CHILDHOOD MORTALITY; CLINICAL PROTOCOL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CRITICALLY ILL PATIENT; DEVELOPING COUNTRY; DRUG DOSE TITRATION; FEMALE; FLUID THERAPY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INFANT; INSULIN TREATMENT; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; SAMPLE SIZE; SEPTIC SHOCK; TREATMENT DURATION;

EID: 79955911743     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181f52847     Document Type: Article

References (16)

1. Branco RG, Garcia PC, Piva JP, et al: Glucose level and risk of mortality in pediatric septic shock. Pediatr Crit Care Med 2005; 6:470-472 (Pubitemid 40980830)
2. Srinivasan V, Spinella PC, Drott HR, et al: Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatr Crit Care Med 2004; 5:329-336
3. Wintergerst KA, Buckingham B, Gandrud L, et al: Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics 2006; 118:173-179 (Pubitemid 46071160)
4. Faustino EV, Apkon M: Persistent hyperglycemia in critically ill children. J Pediatr 2005; 146:30-34 (Pubitemid 40091727)
5. Whitcomb BW, Pradhan EK, Pittas AG, et al: Impact of admission hyperglycemia on hospital mortality in various intensive care unit populations. Crit Care Med 2005; 33: 2772-2777 (Pubitemid 41816411)
6. Chase JG, Shaw G, Le Compte A, et al: Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: A clinical practice change. Crit Care 2008; 12:R49
7. Van den Berghe G, Wouters PJ, Bouillon R, et al: Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control. Crit Care Med 2003; 31:359-366 (Pubitemid 36232926)
8. Van den Berghe G, Wilmer A, Milants I, et al: Intensive insulin therapy in mixed medical/ surgical intensive care units: Benefit versus harm. Diabetes 2006; 55:3151-3159 (Pubitemid 44923655)
9. Vlasselaers D, Milants I, Desmet L, et al: Intensive insulin therapy for patients in paediatric intensive care: A prospective, randomized controlled study. Lancet 2009; 14: 373:547-556
10. NICE-SUGAR Study Investigators, Finfer S, Chittock DR, et al: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360:1283-1297
11. Dellinger RP, Carlet JM, Masur H, et al: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32:858-873 (Pubitemid 38344143)
12. Garcia Branco R, Tasker RC, Ramos Garcia PC, et al: Glycemic control and insulin therapy in sepsis and critical illness J Pediatr (Rio J) 2007; 83(Suppl 5):S128-S136
13. Pollack MM, Ruttimann UE, Getson PR: Pediatric risk of mortality (PRISM) score. Crit Care Med 1988; 16:1110-1116 (Pubitemid 18267293)
14. Goldstein B, Giroir B, Randolph A: International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6:2-8
15. Preissig CM, Hansen I, Roerig PL, et al: A protocolized approach to identify and manage hyperglycemia in a pediatric critical care unit. Pediatr Crit Care Med 2008; 9:581-588
16. Beardsall K, Vanhaesebrouck S, Ogilvy- Stuart AL, et al: Early insulin therapy in very-low-birth-weight infants. N Engl J Med 2008; 359:1873-1884