Noninvasive urinary organic acids test to assess biochemical and nutritional individuality in autistic children

Clinical Biochemistry

Volumn 44, Issue 8-9, 2011, Pages 686-691

  Kałuz̈na Czaplinska, Joanna ^a  

^a LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Autism; Gas chromatography mass spectrometry; Organic acids

Indexed keywords

2 OXOGLUTARIC ACID; 4 HYDROXYBENZOIC ACID; 4 HYDROXYPHENYLACETIC ACID; ADIPIC ACID; ARABINITOL; CARBOXYLIC ACID; CITRIC ACID; HIPPURIC ACID; ISOCITRIC ACID; SUBERIC ACID; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; AUTISM; CAPILLARY GAS CHROMATOGRAPHY; CHEMICAL ANALYSIS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MASS SPECTROMETRY; METABOLIC DISORDER; NON INVASIVE PROCEDURE; NUTRITIONAL DISORDER; NUTRITIONAL STATUS; PRESCHOOL CHILD; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCHOOL CHILD; URINE LEVEL;

ACIDS; AUTISTIC DISORDER; CHILD; CHILD, PRESCHOOL; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE;

EID: 79955879193     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2011.01.015     Document Type: Article

References (39)

1. Newschaffer C.J., Curran L.K. Autism: an emerging public health problem. Public Health Rep 2003, 118(5):393-399.
2. Lam K.S., Aman M.G., Arnold L.E. Neurochemical correlates of autistic disorder: a review of the literature. Res Dev Disabil 2006, 27(3):254-289.
3. Kałuz̈na-Czaplińska J., Grys W., Rynkowski J. Neurotoxic factors in the child's environment as a reason for developmental disorders in autism. Nowa Pediatr 2008, 3:50-57.
4. Manning-Courtney P., Brown J., Molloy C.A., Reinhold J., Murray D. Diagnosis and treatment of autism spectrum disorders. Cur Prob Ped Adol Health 2003, 33:283-304.
5. Shattock P., Whiteley P. Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention. Expert Opin Ther Targets 2002, 6(2):1-9.
6. Kałuz̈na-Czaplińska J., Socha E., Rynkowski J. Determination of homovanillic acid and vanillylmandelic acid in urine of autistic children by gas chromatography/mass spectrometry. Med Sci Monit 2010, 16(9):445-450.
7. Shaw W., Kassen E., Chaves E. Increased excretion of analogs of Krebs cycle metabolites and arabinose in two brothers with autistic features. Clin Chem 1995, 41:1094-1104.
8. Shaw W. Oxalates control is a major new factor in autism therapy. Great Plains Lab 2006.
9. Shaw W., Kassen E., Chaves E. Assessment of antifungal drug therapy in autism by measurement of suspected microbial metabolites in urine with gas chromatography-mass spectrometry. Clin Prac Alter Med 2000, 1(1):15-26.
10. Bell J.G., Sargent J.R., Tocher D.R., Dick J.R. Red blood cell fatty acid compositions in a patient with autistic spectrum disorder: a characteristic abnormality in neurodevelopmental disorders?. Prostaglandins Leukot Essent Fatty Acids 2000, 63(1-2):21-25.
11. Bu B., Ashwood P., Harvey D., King I.B., Water J.V., Jin L.W. Fatty acid compositions of red blood cell phospholipids in children with autism. Prostaglandins Leukot Essent Fatty Acids 2006, 74(4):215-221.
12. Chugani D.C., Sundram B.S., Behen M., Lee M.L., Moore G.J. Evidence of altered energy metabolism in autistic children. Prog Neuropsychopharmacol Biol Psychiatry 1999, 23(4):635-641.
13. Filipek P.A., Juranek J., Nguyen M.T., Cummings C., Gargus J.J. Relative carnitine deficiency in autism. J Autism Dev Disord 2004, 34(6):615-623.
14. James S.J., Cutler P., Melnyk S., Jernigan S., Janak L., Gaylor D.W., Neubrander J.A. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr 2004, 80(6):1611-1617.
15. Whiteley P., Waring R., Williams L., Klovrza L., Nolan F., Smith S., Farrow M., Dodou K., Lough W.J., Shattock P. Spot urinary creatinine excretion in pervasive developmental disorders. Pediatr Int 2006, 48(3):292-297.
16. Clark-Taylor T.B., Clark-Taylor E. Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial beta-oxidation by long chain acyl-CoA dehydrogenase. Med Hypotheses 2004, 62(6):970-975.
17. Poling J.S., Frye R.E. Developmental regression and mitochondrial dysfunction in a child with autism. J Child Neurol 2006, 21(2):170-172.
18. Evans C., Dunstan R.H., Rothkirch T., Roberts T.K., Reichelt K.L., Cosford R., Deed G., Ellis L.B., Sparkes D.L. Altered amino acid excretion in children with autism. Nutr Neurosci 2008, 11:9-17.
19. Kumps A., Duez P., Mardens Y. Metabolic, nutritional and artifactual sources of urinary organic acids: a comprehensive table. Clin Chem 2002, 48:708-717.
20. Burdette C.K. How to assess patient biochemical and nutritional individuality through organic and testing 2006, Townsend Letter for Doctors and Patients, New York.
21. Boulat O., Gradwohl M., Matos V., Guignard J.P., Bachmann C. Organic acids in the second morning urine in a healthy Swiss Paediatric population. Clin Chem Lab Med 2003, 41:1642-1658.
22. Shaw W. Biological treatments for Autism and PDD. 3 rd ed., by William Shaw USA, 2008.
23. Johnson D.W. Contemporary clinical usage of LC/MS: analysis of biologically important carboxylic acids. Clin Biochem 2005, 38:351-361.
24. Ramautar R., Somsen G.W. Direct sample injection for capillary electrophoretic determination of organic acids in cerebrospinal fluid. Anal Bioanal Chem 2007, 293-301.
25. American Psychiatric Association Diagnostic and statistical manual of mental disorders 1994, American Psychiatric Association, Washington, DC. 4th ed.
26. Portaluppi F., Touitou Y., Smolensky M.H. Ethical and methodological standards for laboratory and medical biological rhythm research. Chronobiol Int 2008, 25:999-1016.
27. Kuśmierek K., Głowacki R., Bald E. Analysis of urine for cysteine, cysteinylglycine, and homocysteine by high-performance liquid chromatography. Anal Bioanal Chem 2006, 385:855-860.
28. Kuhara T. Diagnosis of inborn errors of metabolism using filter paper urine, urease treatment, isotope dilution and gas chromatography-mass spectrometry. J Chromatogr B 2001, 758:3-25.
29. Anderson G.M., Hoshino Y. Neurochemical studies of autism. Handbook of autism and pervasive developmental disorders 1997, 325-343. John Wiley & Sons, New York. 2nd ed. D.J. Cohen, F.R. Volkmar (Eds.).
30. Kałuz̈na-Czaplińska J., Michalska M., Rynkowski J. Determination of tryptophan in urine of autistic and healthy children by gas chromatography/mass spectrometry. Med Sci Monit 2010, 16(10):488-492.
31. Bongiovanni B., Feinerman J. Amino Acid Profiling. Townsend Lett Doctors Patients 2003, 245:38-42.
32. Page T. Metabolic approaches to the treatment of autistic spectrum disorder. J Autism Dev Disord 2000, 30:461-467.
33. Manzi B., Loizzo A.L., Giana G. Autism and metabolic diseases. J Child Neurol 2008, 23:307-314.
34. Zecavati N., Spence S.J. Neurometabolic disorders and dysfunction in autism spectrum disorders. Curr Neurol Neurosci Rep 2009, 9:129-136.
35. Rogers S.A. Using organic acids to diagnose and manage recalcitrant patients. Altern Ther Health Med 2006, 12:44-51.
36. Inouye M., Mio T., Sumino K. Dicarboxylic acids as markers of fatty acid peroxidation in diabetes. Atherosclerosis 2000, 148:197-202.
37. Peters V., Garbade S.F., Langhans C.D., et al. Qualitative urinary organic acid analysis: Methodological approaches and performance. J Inherit Metab Dis 2008, 31:690-696.
38. Jones M.G., Cooper E., Amjad S., et al. Urinary and plasma organic acids and amino acids in chronic fatigue syndrome. Clin Chim Acta 2005, 361:150-158.
39. Elder J.H., Shankar M., Shuster J., Theriaque D., Burns S., Sherrill L. The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial. J Autism Dev Disord 2006, 36:413-420.