In vitro anticancer activity of doxorubicin-loaded gelatin-coated magnetic iron oxide nanoparticles

Journal of Microencapsulation

Volumn 28, Issue 4, 2011, Pages 286-293

  Gaihre, Babita ^a   Khil, Myung S ^b   Kim, Hak Y ^b  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b Chonbuk National University   (South Korea)

Author keywords

cell uptake; cytotoxicity; drug release; gelatin; in vitro anticancer activity; magnetic iron oxide; surface coating

Indexed keywords

DOXORUBICIN; DRUG CARRIER; GELATIN COATED MAGNETIC IRON OXIDE NANOPARTICLE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; FERRIC ION; FERRIC OXIDE; GELATIN; NANOPARTICLE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL VIABILITY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG TARGETING; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; CHEMISTRY; DOSE RESPONSE; DRUG SCREENING; METHODOLOGY;

ANTIBIOTICS, ANTINEOPLASTIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG CARRIERS; DRUG SCREENING ASSAYS, ANTITUMOR; FERRIC COMPOUNDS; GELATIN; HELA CELLS; HUMANS; NANOPARTICLES;

EID: 79955860521     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2011.559286     Document Type: Article

References (31)

1. Alexiou C, Arnold W, Klein RJ, Parak FG, Hulin P, Bergemann C, Erhardt W, Wagenpfeil S, Lubbe AS. Locoregional cancer treatment with magnetic drug targeting. Cancer Res, 2000;60:6641-8.
2. Alexiou C, Jurgons R, Schmid RJ, Bergemann C, Henke J, Erhardt W. Magnetic drug targeting-biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment. J. Drug Target, 2003;11:139-49. (Pubitemid 37236327)
3. Arias JL, Gallardo V, Lopera SAG, Plaza RC, Delgado AV. Synthesis and characterization of poly(ethyl-2-cyanoacrylate) nanoparticles with a magnetic core. J Controlled Release, 2001;77:309-21. (Pubitemid 33145482)
4. Bien S, Ritter CA, Gratz M, Sperker B, Sonnemann J, Beck JF, Kroemer HK. Nuclear factor-kB mediates up-regulation of cathepsin B by doxorubicin in tumor cells. Mol Pharmacol, 2004;65:1092-102. (Pubitemid 38543480)
5. Danesi R, Fogli S, Gennari A, Conte P, Del Tacca M. Pharmacokineticpharmacodynamic relationships of the anthracycline anticancer drugs. Clin Pharmacokinet, 2002;41:431-44. (Pubitemid 34753680)
6. Engvall E, Ruoslahti E. Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. Int J cancer, 2006;20:1-5.
7. Gaihre B, Aryal S, Khil MS, Kim HY. Encapsulation of Fe3O4 in gelatin nanoparticles: Effect of different parameters on size and stability of the colloidal dispersion. J Microencapsul, 2008a;25:21-30.
8. Gaihre B, Khil MS, Kang HK, Kim HY. Bioactivity of gelatin coated magnetic iron oxide nanoparticles: In vitro Evaluation. J Mater Sci - Mater Med, 2009a;20:573-81.
9. Gaihre B, Khil MS, Lee DR, Kim HY. Gelatin coated magnetic iron oxide nanoparticles as carrier system: Drug-loading and in vitro drug release study. Int J Pharm, 2009b;365:180-9.
10. Gaihre B, Lee YH, Khill MS, Yi HK, Kim HK. In-vitro cytotoxicity and cell uptake study of gelatin-coated magnetic iron oxide. J Microencapsulation. Manuscript accepted and under preparation for publication nanoparticles
11. Gaihre B, Parajuli DC, Seo HC, Khil MS, Kim HY. Effect of different parameters on gelatin adsorption and stability of the colloidal disperson of gelatin coated magnetic iron oxide nanoparticles. Adsorpt. Sci. Technol, 2008b;26:279-90.
12. Gupta AK, Curtis ASG. Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors. Biomaterials, 2004;25:3029-40. (Pubitemid 38210195)
13. Gupta AK, Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials, 2005;26: 3995-4021. (Pubitemid 40044762)
14. Illes E, Tombacz E. The effect of humic acid adsorption on pH-dependent surface charging and aggregation of magnetite nanoparticles. J Colloid Interface Sci, 2006;295:115-23. (Pubitemid 41742072)
15. Jain TK, Richey J, Strand M, Leslie-Pelecky DL, Flask CA, Labhasetwar V. Magnetic nanoparticles with dual functional properties: Drug delivery and magnetic resonance imaging. Biomaterials, 2008;29:4012-21.
16. Kushibiki T, Matsuoka H, Tabata Y. Synthesis and physical characterization of poly(ethylene glycol)-gelatin conjugates. Biomacromolecules, 2004;5:202-8. (Pubitemid 38181331)
17. Leo E, Cameroni R, Forni F. Dynamic dialysis for the drug release evaluation from doxorubicin-gelatin nanoparticle conjugates. Int J Pharm, 1999;180:23-30. (Pubitemid 29131439)
18. Leo E, Vandelli MA, Cameroni R, Forni F. Doxorubicin-loaded gelatin nanoparticles stabilized by glutaraldehyde: Involvement of the drug in the cross-linking process. Int J Pharm, 1997;155:75-82. (Pubitemid 27368124)
19. Links M, Brown R. Clinical relevance of the molecular mechanisms of resistance to anti-cancer drugs. Expert Rev Mol Med, 1999;1999:1-21.
20. Lu AH, Salabas EL, Schüth F. Magnetic nanoparticles: Synthesis, protection, functionalization, and application. Angew Chem Int Ed, 2007;46:1222-44.
21. Lubbe AS, Alexiou C, Bergemann C. Clinical applications of magnetic drug targeting. J Surg Res, 2001;95:200-6. (Pubitemid 34953556)
22. Lubbe AS, Bergemann C, Riess H, Schriever F, Reichardt P, Possinger K, Matthias M, Dörken B, Herrmann F, Gü rtler R, et al. Clinical experiences with magnetic drug targeting: A phase I study with 4-epidoxrubicin in 14 patients with advanced solid tumors. Cancer Res, 1996;56:4686-93. (Pubitemid 26338071)
23. Mornet S, Vasseur S, Grasset F, Duguet E. Magnetic nanoparticle design for medical diagnosis and therapy. J Mater Chem, 2004;14: 2161-75.
24. Okassa LN, Marchais H, Eyrolles LD, Jonathan SC, Souce M, Dubois P, Chourpa I. Development and characterization of sub-micron poly(d,l-lactide-co- glycolide) particles loaded with magnetite/ maghemite nanoparticles. Int J Pharm, 2008;302:187-96.
25. Saravanan M, Bhaskar K, Maharajan G, Pillai KS. Ultrasonically controlled release and targeted delivery of diclofenac sodium via gelatin magnetic microspheres. Int J Pharm, 2004;283:71-82. (Pubitemid 39200928)
26. Selim KMK, Ha YS, Kim SJ, Chang Y, Kim TJ, Lee GH, Kang IK. Surface modification of magnetite nanoparticles using lactobionic acid and their interaction with hepatocytes. Biomaterials, 2007;28: 710-6. (Pubitemid 44754877)
27. Wilhelm C, Billotey C, Roger J, Pons JN, Bacri JC, Gazeau F. Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating. Biomaterials, 2003;24:1001-11. (Pubitemid 36024170)
28. Wu XX, Kakehi Y, Mizutani Y, Kamamoto T, Kinoshita H, Isogawa Y, Terachi T, Ogawa O. Doxorubicin enhances TRAIL-induced apoptosis in prostate cancer. Int J Oncol, 2002;20:949-54.
29. Young RC, Ozols RF, Myers CE. The anthracycline antineoplastic drugs. N Engl J Med, 1981;305:139-52.
30. Young S, Wong M, Tabata Y, Mikos AG. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release, 2005;109:256-74. (Pubitemid 41737269)
31. Zhang Y, Kohler N, Zhang M. Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. Biomaterials, 2002;23:1553-61. (Pubitemid 34158578)