Preparation of 2-fluoro-3-aminophenylboronates via directed ortho -metalation

Synthesis

Volumn , Issue 10, 2011, Pages 1604-1608

  Zhichkin, Paul E ^a   Krasutsky, Sergiy G ^a   Beer, Catherine M ^a   Rennells, W Martin ^a   Lee, Seung H ^b   Xiong, Jin Ming ^b  

^a ALBANY MOLECULAR RESEARCH INC   (United States)

^b Gilead Sciences   (United States)

Author keywords

amines; boronates; metalation; protecting groups; regioselectivity

Indexed keywords

AROMATIC AMINES; BORONATES; DEPROTECTION; FLUOROANILINES; IN-SITU; METALATIONS; PROTECTING GROUPS;

CRYSTALLINE MATERIALS; FLUORINE;

AMINES;

1 (2 CHLORO 6 FLUOROPHENYL) 2,2,5,5 TETRAMETHYL 1,2,5 AZADISILOLIDINE; 1 (2 FLUORO 5 METHYLPHENYL) 2,2,5,5 TETRAMETHYL 1,2,5 AZADISILOLIDINE; 1 (2 FLUORO 6 METHYLPHENYL) 2,2,5,5 TETRAMETHYL 1,2,5 AZADISILOLIDINE; 1 (2 FLUOROPHENYL) 2,2,5,5 TETRAMETHYL 1,2,5 AZADISILOLIDINE; 1 (2,6 DIFLUOROPHENYL) 2,2,5,5 TETRAMETHYL 1,2,5 AZADISILOLIDINE; 1 (5 CHLORO 2 FLUOROPHENYL) 2,2,5,5 TETRAMETHYL 1,2,5 AZADISILOLIDINE; 2 FLUORO 3 AMINOPHENYLBORONIC ACID DERIVATIVE; 2 FLUORO 6 METHYL 3 (4,4,5,5 TETRAMETHYL 1,3,2 DIOXABOROLAN 2 YL)ANILINE; 2,2,5,5 TETRAMETHYL 1 AZA 2,5 DISILA CYCLOPENTANE; 2,6 DIFLUORO 3 (4,4,5,5 TETRAMETHYL 1,3,2 DIOXABOROLAN 2 YL)ANILINE; 3 (5,5 DIMETHYL 1,3,2 DIOXABORINAN 2 YL) 2 FLUORO 5 METHYLANILINE; 3 (5,5 DIMETHYL 1,3,2 DIOXABORINAN 2 YL) 2 FLUOROANILINE; 3 (5,5 DIMETHYL 1,3,2 DIOXABORINAN 2 YL) 2,6 DIFLUOROANILINE; 5 CHLORO 3 (5,5 DIMETHYL 1,3,2 DIOXABORINAN 2 YL) 2 FLUOROANILINE; 6 CHLORO 3 (5,5 DIMETHYL 1,3,2 DIOXABORINAN 2 YL) 2 FLUOROANILINE; ANILINE DERIVATIVE; AROMATIC AMINE; BORIC ACID; BORONIC ACID DERIVATIVE; CYCLOPENTANE DERIVATIVE; FLUORINE; FLUOROANILINE DERIVATIVE; TRIISOPROPYLBORIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; DEPROTECTION REACTION; ORTHO METALATION REACTION; PURIFICATION; SYNTHESIS;

EID: 79955860318     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1260019     Document Type: Article

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