Hypoxanthine guanine phosphoribosyltransferase distorts the purine ring of nucleotide substrates and perturbs the p K a of bound xanthosine monophosphate

Biochemistry

Volumn 50, Issue 19, 2011, Pages 4184-4193

  Gogia, Spriha ^a   Balaram, Hemalatha ^b   Puranik, Mrinalini ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BINDING POCKETS; ELECTRONIC ABSORPTION; ENZYMATIC EFFICIENCY; MONOPHOSPHATES; NUCLEOBASES; PHOSPHORIBOSYLTRANSFERASE; PLASMODIUM FALCIPARUM; PRECISE ASSEMBLY; PURINE RING; SUBSTRATE SPECIFICITY; ULTRAVIOLET RESONANCE RAMAN SPECTROSCOPY; XANTHOSINE;

ABSORPTION SPECTROSCOPY; CATALYSIS; NUCLEOTIDES; POSITIVE IONS; PROTEINS; RAMAN SPECTROSCOPY; RESONANCE; SUGARS;

SUBSTRATES;

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; XANTHOSINE; XANTHOSINE PHOSPHATE;

ARTICLE; BACTERIAL STRAIN; ENZYME BINDING; ENZYME STRUCTURE; HUMAN; PKA; PRIORITY JOURNAL; RAMAN SPECTROMETRY; ULTRAVIOLET SPECTROSCOPY;

5'-GUANYLIC ACID; ANIMALS; CATALYTIC DOMAIN; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INOSINE MONOPHOSPHATE; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PURINE NUCLEOTIDES; RIBONUCLEOTIDES; SPECTRUM ANALYSIS, RAMAN; SUBSTRATE SPECIFICITY; TOXOPLASMA;

PLASMODIUM FALCIPARUM;

EID: 79955859954     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi102039b     Document Type: Article

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