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(Epub ahead of print). The North American Pancreatitis Study 2 (NAPS2) is the largest epidemiological study of pancreatitis in the United States. In this study, 1000 pancreatitis patients (540 chronic, 460 recurrent acute) were prospectively enrolled from 20 US centers from years 2000 to 2006. In this article, the investigators describe the clinical and etiological profile of chronic pancreatitis patients in the NAPS2 cohort
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Cote GA, Yadav D, Slivka A, et al.: Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis. Clin Gastroenterol Hepatol 2010 (Epub ahead of print). The North American Pancreatitis Study 2 (NAPS2) is the largest epidemiological study of pancreatitis in the United States. In this study, 1000 pancreatitis patients (540 chronic, 460 recurrent acute) were prospectively enrolled from 20 US centers from years 2000 to 2006. In this article, the investigators describe the clinical and etiological profile of chronic pancreatitis patients in the NAPS2 cohort.
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Clin Gastroenterol Hepatol
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Cote, G.A.1
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This prospective multicenter study describes the demographics, risk factor distribution, etiologic profile, pancreatic morphology, and treatment in 893 chronic pancreatitis patients prospectively enrolled from 21 referral centers across Italy from 2000 to 2005
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Frulloni L, Gabbrielli A, Pezzilli R, et al.: Chronic pancreatitis: report from a multicenter Italian survey (PanCroInfAISP) on 893 patients. Dig Liver Dis 2009;41:311-7. This prospective multicenter study describes the demographics, risk factor distribution, etiologic profile, pancreatic morphology, and treatment in 893 chronic pancreatitis patients prospectively enrolled from 21 referral centers across Italy from 2000 to 2005.
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See Cote et al. [14•]. In this study, the distribution of drinking and smoking behaviors in the NAPS2 cohort was described. The relationship between alcohol and smoking with recurrent acute and chronic pancreatitis was assessed using multivariable regression analyses. Only very heavy drinking (five or more drinks per day) was associated with chronic pancreatitis. A dose-dependent relationship was seen for smoking with recurrent acute and chronic pancreatitis
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Yadav D, Hawes RH, Brand RE, et al.: Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med 2009;169:1035-45. See Cote et al. [14•]. In this study, the distribution of drinking and smoking behaviors in the NAPS2 cohort was described. The relationship between alcohol and smoking with recurrent acute and chronic pancreatitis was assessed using multivariable regression analyses. Only very heavy drinking (five or more drinks per day) was associated with chronic pancreatitis. A dose-dependent relationship was seen for smoking with recurrent acute and chronic pancreatitis.
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Arch Intern Med
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The aim of this large German study was to determine the prevalence of pancreas and liver injury in alcoholic subjects. The authors identified all 620 (8%) subjects with an alcoholism diagnosis among 7541 autopsy cases at their institution from 1999 to 2004. They used 100 controls without alcoholism diagnosis matched by age and gender for comparison. The prevalence of chronic pancreatitis and pancreatic fibrosis was 13.7% and 38.9%, respectively, whereas that of cirrhosis and heavy steatosis was 30% and 37%, respectively. Concurrent liver and pancreatic injury was common, with ∼70% of patients with cirrhosis having pancreatic fibrosis or chronic pancreatitis and ∼80% of patients with chronic pancreatitis having either heavy steatosis or cirrhosis
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Pace A, deWeerth A, Berna M, et al.: Pancreas and liver injury are associated in individuals with increased alcohol consumption. Clin Gastroenterol Hepatol 2009;7:1241-6. The aim of this large German study was to determine the prevalence of pancreas and liver injury in alcoholic subjects. The authors identified all 620 (8%) subjects with an alcoholism diagnosis among 7541 autopsy cases at their institution from 1999 to 2004. They used 100 controls without alcoholism diagnosis matched by age and gender for comparison. The prevalence of chronic pancreatitis and pancreatic fibrosis was 13.7% and 38.9%, respectively, whereas that of cirrhosis and heavy steatosis was 30% and 37%, respectively. Concurrent liver and pancreatic injury was common, with ∼70% of patients with cirrhosis having pancreatic fibrosis or chronic pancreatitis and ∼80% of patients with chronic pancreatitis having either heavy steatosis or cirrhosis.
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Kristiansen L, Gronbaek M, Becker U, Tolstrup JS: Risk of pancreatitis according to alcohol drinking habits: a population-based cohort study. Am J Epidemiol 2008;168:932-7. Investigators in this study used the Copenhagen City heart study cohort consisting of 17,905 subjects enrolled from 1976 to 2003 to determine the risk of acute or chronic pancreatitis during a mean follow-up of 20 years based on levels of alcohol consumption at the time of baseline evaluation. The role of drinking frequency and type of beverage was also evaluated. The investigators found that the risk of pancreatitis increased with the level of alcohol consumption.
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This study used data from existing observational studies to conduct a systematic review and meta-analysis of the relationship between alcohol consumption and pancreatitis. The authors report that there appears to be a threshold of alcohol consumption above which the risk of pancreatitis increases significantly (4 drinks/day)
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Irving HM, Samokhvalov AV, Rehm J: Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis. JOP 2009;10:387-92. This study used data from existing observational studies to conduct a systematic review and meta-analysis of the relationship between alcohol consumption and pancreatitis. The authors report that there appears to be a threshold of alcohol consumption above which the risk of pancreatitis increases significantly (4 drinks/day).
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