Optimization and application of a fluorimetric assay for the identification of histone deacetylase inhibitors from plant origin

Pharmaceutical Biology

Volumn 49, Issue 6, 2011, Pages 658-668

  Krasteva, Stanimira ^a   Heiss, Elke ^a   Krenn, Liselotte ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

enzymatic assay; HDAC inhibition; Leonuri herba; plant compounds

Indexed keywords

ALKALOID; COUMARIN DERIVATIVE; DRUG METABOLITE; FLAVONOID; HISTONE DEACETYLASE INHIBITOR; LEONURI HERBA EXTRACT; PLANT EXTRACT; SOLVENT; TANNIN DERIVATIVE; UNCLASSIFIED DRUG;

ANGIOSPERM; ANIMAL CELL; ARTICLE; AUTOFLUORESCENCE; BIOASSAY; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG DETERMINATION; ENZYMATIC ASSAY; FLUOROMETRY; FRACTIONATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; LEONURI HERBA; NONHUMAN; PROCESS OPTIMIZATION; RAT; REPRODUCIBILITY; TEMPERATURE SENSITIVITY;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE; ENZYME ASSAYS; FLUOROMETRY; HISTONE DEACETYLASE INHIBITORS; HUMANS; KRAMERIACEAE; LEONURUS; OLIGOSACCHARIDES; PLANT EXTRACTS; RATS;

LAMIACEAE; LEONURUS CARDIACA;

EID: 79955846069     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2010.536556     Document Type: Article

References (29)

1. Basaran AA, Calis I, Anklin C, Nishibe S, Sticher O. (1988) Lavandulifolioside. A new phenylpropanoid glycoside from Stachys lavandulifolia. Helv Chim Acta, 71, 1483-1490.
2. Blaschek W, Frohne D, Loew D. (2009) Ratanhiae radix. In: Wichtl M, ed. Teedrogen und Phytopharmaka. 5th edition. Stuttgart: Wiss Verlags GmbH, 550-551.
3. Bolden JE, Peart MJ, Johnstone RW. (2006). Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov, 5, 769-784. (Pubitemid 44348499)
4. Bontempo P, Mita L, Miceli M, Doto A, Nebbioso A, De Bellis F, Conte M, Minichiello A, Manzo F, Carafa V, Basile A, Rigano D, Sorbo S, Castaldo Cobianchi R, Schiavone EM, Ferrara F, De Simone M, Vietri M, Ciof M, Sica V, Bresciani F, de Lera AR, Altucci L, Molinari AM. (2007). Feijoa sellowiana derived natural favone exerts anti-cancer action displaying HDAC inhibitory activities. Int J Biochem Cell Biol, 39, 1902-1914. (Pubitemid 47321350)
5. Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 72, 248-254.
6. Carew JS, Giles FJ, Nawrocki ST. (2008). Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy. Cancer Lett, 269, 7-17.
7. Chen IH, Lu MC, Du YC, Yen MH, Wu CC, Chen YH, Hung CS, Chen SL, Chang FR, Wu YC. (2009). Cytotoxic triterpenoids from the stems of Microtropis japonica. J Nat Prod, 72, 1231-1236.
8. Chung IM, Kim MY, Park WH, Moon HI. (2008). Histone deacetylase inhibitors from the rhizomes of Zingiber zerumbet. Pharmazie, 63, 774-776.
9. Dokmanovic M, Marks PA. (2005). Prospects: Histone deacetylase inhibitors. J Cell Biochem, 96, 293-304. (Pubitemid 41437862)
10. Frew AJ, Johnstone RW, Bolden JE. (2009). Enhancing the apoptotic and therapeutic efects of HDAC inhibitors. Cancer Lett, 280, 125-133.
11. Granger A, Abdullah I, Huebner F, Stout A, Wang T, Huebner T, Epstein JA, Gruber PJ. (2008). Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. Faseb J, 22, 3549-3560.
12. Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH. (2009). HDAC2 negatively regulates memory formation and synaptic plasticity. Nature, 459, 55-60.
13. Hiller K, Loew D. (2009) Leonuri cardiacae herba. In: Wichtl M, ed. Teedrogen und Phytopharmaka. 5th edition. Stuttgart: Wiss Verlags GmbH, 384-385.
14. Kim MJ, Ahn K, Park SH, Kang HJ, Jang BG, Oh SJ, Oh SM, Jeong YJ, Heo JI, Suh JG, Lim SS, Ko YJ, Huh SO, Kim SC, Park JB, Kim J, Kim JI, Jo SA, Lee JY. (2009). SIRT1 regulates tyrosine hydroxylase expression and diferentiation of neuroblastoma cells via FOXO3a. FEBS Lett, 583, 1183-1188.
15. Marks PA, Xu WS. (2009). Histone deacetylase inhibitors: Potential in cancer therapy. J Cell Biochem, 107, 600-608.
16. Mazitschek R, Patel V, Wirth DF, Clardy J. (2008). Development of a fuorescence polarization based assay for histone deacetylase ligand discovery. Bioorg Med Chem Lett, 18, 2809-2812. (Pubitemid 351608890)
17. Newkirk TL, Bowers AA, Williams RM. (2009). Discovery, biological activity, synthesis and potential therapeutic utility of naturally occurring histone deacetylase inhibitors. Nat Prod Rep, 26, 1293-1320.
18. Ogbomo H, Michaelis M, Kreuter J, Doerr HW, Cinatl J Jr. (2007). Histone deacetylase inhibitors suppress natural killer cell cytolytic activity. FEBS Lett, 581, 1317-1322. (Pubitemid 46452605)
19. Oka S, Ago T, Kitazono T, Zablocki D, Sadoshima J. (2009). Te role of redox modulation of class II histone deacetylases in mediating pathological cardiac hypertrophy. J Mol Med, 87, 785-791.
20. Olson EN, Schneider MD. (2003). Sizing up the heart: Development redux in disease. Genes Dev, 17, 1937-1956. (Pubitemid 36999321)
21. Ropero S, Esteller M. (2007). Te role of histone deacetylases (HDACs) in human cancer. Mol Oncol, 1, 19-25. (Pubitemid 46776612)
22. Smith KT, Workman JL. (2009). Histone deacetylase inhibitors: Anticancer compounds. Int J Biochem Cell Biol, 41, 21-25.
23. Saukel J, Gerlach S, Kubelka W. (2006) Pfanzen in der österreichischen Volksmedizin. Die.,VOLKSMED-Datenbank". Sci Pharm, 74, S36.
24. Son IH, Lee SI, Yang HD, Moon HI. (2007). bis(4-Hydroxybenzyl) sulfde: A sulfur compound inhibitor of histone deacetylase isolated from root extract of Pleuropterus ciliinervis. Molecules, 12, 815-820.
25. Stefanko DP, Barrett RM, Ly AR, Reolon GK, Wood MA. (2009). Modulation of long-term memory for object recognition via HDAC inhibition. Proc Natl Acad Sci USA, 106, 9447-9452.
26. Wall ME, Wani MC, Brown DM, Fullas F, Olwald JB, Josephson FF, Torton NM, Pezzuto JM, Beecher WW, Farnsworth NR, Cordell GA, Kinghorn AD. (1996). Efects of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal. Phytomedicine, 3, 281-285. (Pubitemid 126504570)
27. Wegener D, Hildmann C, Riester D, Schwienhorst A. (2003). Improved fuorogenic histone deacetylase assay for high-throughput-screening applications. Anal Biochem, 321, 202-208. (Pubitemid 37162740)
28. Witt O, Deubzer HE, Milde T, Oehme I. (2009). HDAC family: What are the cancer relevant targets? Cancer Lett, 277, 8-21.
29. Zhang L, Fang H, Xu W. (2009). Strategies in developing promising histone deacetylase inhibitors. Med Research Reviews, 4, 1-16.