Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity

Retrovirology

Volumn 8, Issue , 2011, Pages

  Bhakta, Sushma J ^a   Shang, Liang ^a   Prince, Jessica L ^a   Claiborne, Daniel T ^a   Hunter, Eric ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; LEUCINE; MUTANT PROTEIN; TYROSINE; VIRUS PROTEIN; VIRULENCE FACTOR; VIRUS ENVELOPE PROTEIN; VIRUS FUSION PROTEIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; GENE CONSTRUCT; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LIFE CYCLE; MUTAGENESIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; VIRION; VIRUS ENVELOPE; VIRUS INFECTIVITY; VIRUS REPLICATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; CELL LINE; CERCOPITHECUS; GENETICS; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS; VIRUS ENTRY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; DNA MUTATIONAL ANALYSIS; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV-1; HUMANS; LEUCINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; TYROSINE; VIRAL FUSION PROTEINS; VIRULENCE FACTORS; VIRUS INTERNALIZATION;

EID: 79955840790     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-8-37     Document Type: Article

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