Inhibitory effect of arenobufagin on the adhesion, invasion and migration of human hepatoma carcinoma cells

Chinese Pharmacological Bulletin

Volumn 27, Issue 1, 2011, Pages 19-23

  Cao, Hui Hui ^a   Zhang, Dong Mei ^a   Liu, Jun Shan ^a   Hou, Chun Ying ^a   Kurihara, Hiroshi ^a   Ye, Wen Cai ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

Adhesion; Arenobufagin; HepG2 cells; Invasion; Migration; MMPs

Indexed keywords

ANTINEOPLASTIC AGENT; ARENOBUFAGIN; GELATINASE A; GELATINASE B; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL STRAIN HEPG2; CELL VIABILITY; DOSE RESPONSE; DOWN REGULATION; HEPATOMA CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 79955840241     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Kurosawa M, Numazawa S, Tani Y, et al. ERK signaling mediates the induction of inflammatory cytokines by bufalin in human monocytic cells [J]. Am J Physiol Cell Physiol, 2000,278(3):500-8.
2. Kurosawa M, Tani Y, Nishimura S, et al. Distinct PKC isozymes regulate bufalin-induced differentiation and apoptosis in human monocytic cells [J]. Am J Physiol Cell Physiol, 2001,280(3):459-64.
3. Wang L, Wu J, Li M, et al. Pilot study on the mechanisms of growth inhibitory effect of cinobufagin on HeLa cells [J]. China J Oncol, 2005,27(12):717-20.
4. +-ATPase inhibition in the early changes in proto oncogene expression [J]. Biochem Pharmacol, 1996,52(2):321-9.
5. Eeffrth T, Davey M, Olbrieh A, et al. Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells [J]. Blood Cells Mol Dis, 2002,28(2):160-8.
6. Jiang F, Deng X M, Han X H, et al. Effects of extracts from Venenum bufonis with different solvents on immunocyte functions of mice in vitro [J]. Chin J Pharmacol Toxicol, 2008,22(1):63-8.
7. Wang N Y, Li S Y, Zhao W, et al. Study the effect of antiangiogenesis of ansenic trioxide in combination with cinobufacin on chick embryo chorioallantoic membrane (CAM) [J]. Chin Clin Oncol, 2006,11(7):494-7.
8. Lee D Y, Yasuda M, Yamamoto T, et al. Bufalin inhibits endothelial cell proliferation and angiogenesis in vitro [J]. Life Sci, 1997,60 (2):127-34
9. Zhang Y, Qiu Y K, Chen J Y, et al. Chemical constituents from the skin of Bufo bufo gargarizans Cantor [J]. J Shenyang Pharma Univ, 2007,24(8):484-7.
10. Liotta L A, Stetler-Stevenson W G. Tumor invasion and metastasis: an imbalance of positive and negative regulation [J]. Cancer Res, 1991,51(18):5054-9.
11. Zhang L B, Zhang W D, Wang C X, et al. The inhibitive effect of polypeptide extract from sorpion venom (PESV) on invasion and metastasis of pancreatic cancer cells in vitro and its primary mechanism [J]. Chin Pharmacol Bull, 2009,25(6):820-4.
12. Wang X F, Zhou Q M, Su S B, Experimental study on Baicalein inhibiting the invasion and migration of human breast cancer cells [J]. Chin Pharmacol Bull, 2010,26(6):745-50.
13. Nabeshima K, Inoue T, Shimao Y, et al. Matrix metalloproteinases in tumor invasion : Role for cell migration [J]. Pathol Int, 2002, 52:255-64.
14. Roeb E, Bosserhoff A K, Hamacher S, et al. Enhanced migration of tissue inhibitor of metalloproteinase overexpressing hepatoma cells is attributed to gelatinases: Relevance to intracellular signaling pathway [J]. World J Gastroenterol, 2005,11(8):1096-104.
15. Hsiang C Y, Wu S L, Chen J C, et al. Acetaldehyde induces matrix metalloproteinase-9 gene expression via nuclear factor-κB and activator protein 1 signaling pathways in human hepatocellular carcinoma cells : Association with the invasive potential [J]. Toxicol Lett, 2007,171:78-86.